Detection of influenza B viruses with reduced sensitivity to neuraminidase inhibitor in Morocco during 2014/15 season

Elfalki, Fatimah; Ihazmad, Hassan; Bimouhen, Abderrahman; Regragui, Zakia; Benkaroum, Samira; Bakri, Youssef; Barakat, Amal

doi:10.26719/2016.22.7.452

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…[16][17][18] In the same issue of the EMHJ, influenza outbreak characterization from other regional countries such as Jordan, lebanon, Morocco, and yemen were also published. [21][22][23][24] This is a step forward in the Eastern Mediterranean region; however, to establish effective prevention policies, more data including the health and economic burden of influenza over several seasons in the regional countries is needed.…”

Section: Discussionmentioning

confidence: 99%

A Snapshot of Influenza Surveillance, Vaccine Recommendations, and Vaccine Access, Drivers, and Barriers in Selected Middle Eastern and North African Countries

Awaidy¹,

Althaqafi²,

Dbaibo³

2018

Oman Med J

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Section: Discussionmentioning

confidence: 99%

A Snapshot of Influenza Surveillance, Vaccine Recommendations, and Vaccine Access, Drivers, and Barriers in Selected Middle Eastern and North African Countries

Awaidy¹,

Althaqafi²,

Dbaibo³

2018

Oman Med J

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“…Furthermore, a recent study found that the proportion of deaths in children hospitalized with influenza attributable to influenza B virus is 1.1%, compared to 0.4% for influenza A virus (14). Finally, oseltamivir treatment seems to be less effective against influenza B viruses than against influenza A viruses (15)(16)(17), and oseltamivir-resistant mutants emerge (18)(19)(20), sometimes without a loss of fitness (21,22). Current influenza virus vaccines are an effective prophylactic countermeasure against influenza B virus infections.…”

mentioning

confidence: 99%

Chimeric Hemagglutinin Constructs Induce Broad Protection against Influenza B Virus Challenge in the Mouse Model

Ermler

Kirkpatrick

Sun

et al. 2017

J Virol

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Seasonal influenza virus epidemics represent a significant public health burden. Approximately 25% of all influenza virus infections are caused by type B viruses, and these infections can be severe, especially in children. Current influenza virus vaccines are an effective prophylaxis against infection but are impacted by rapid antigenic drift, which can lead to mismatches between vaccine strains and circulating strains. Here, we describe a broadly protective vaccine candidate based on chimeric hemagglutinins, consisting of globular head domains from exotic influenza A viruses and stalk domains from influenza B viruses. Sequential vaccination with these constructs in mice leads to the induction of broadly reactive antibodies that bind to the conserved stalk domain of influenza B virus hemagglutinin. Vaccinated mice are protected from lethal challenge with diverse influenza B viruses. Results from serum transfer experiments and antibody-dependent cell-mediated cytotoxicity (ADCC) assays indicate that this protection is antibody mediated and based on Fc effector functions. The present data suggest that chimeric hemagglutinin-based vaccination is a viable strategy to broadly protect against influenza B virus infection. While current influenza virus vaccines are effective, they are affected by mismatches between vaccine strains and circulating strains. Furthermore, the antiviral drug oseltamivir is less effective for treating influenza B virus infections than for treating influenza A virus infections. A vaccine that induces broad and long-lasting protection against influenza B viruses is therefore urgently needed.

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A Systematic Review of Influenza Epidemiology and Surveillance in the Eastern Mediterranean and North African Region

et al. 2022

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Seasonal influenza represents a huge health burden, resulting in significant mortality and morbidity. Following the 2009 H1N1 pandemic, focus has been directed on the burden of influenza globally. Country and regional disease burden estimates play important roles in helping inform decisions on national influenza intervention programmes. Despite improvements in influenza surveillance following the 2009 pandemic, many opportunities remain unexplored in the Eastern Mediterranean and North African (EMNA) region, which has a high prevalence of patients with chronic disease and thus a population at high risk of influenza complications. We conducted a systematic literature review of Embase, Medline, Scopus and the Cochrane Database of Systematic Reviews from 1 January 1998 to 31 January 2020 covering the EMNA region with the aim to describe the epidemiology of influenza in the region and assess the influenza epidemiological surveillance research landscape. Relevant data on study characteristics, population, clinical/virology characteristics and epidemiology were extracted and summarised descriptively. Of the 112 studies identified for inclusion, 90 were conducted in the Eastern Mediterranean region, 19 in North Africa and three across the EMNA region. Data were reported on 314,058 laboratory-confirmed influenza cases, 96 of which were derived from surveillance systems. Amongst the surveillance studies, the percentage of positive cases reported ranged from 1% to 100%. The predominantly identified influenza strain was strain A; H1N1 was the most prominent circulating subtype. Typing was performed in approximately 75% and subtyping in 50% of studies, respectively. Data on those considered most at risk for influenza complications were collected in 21% of studies, highlighting a regional gap for these data. Our review reveals existing gaps in regional estimates of influenza health and economic burden, hospitalisation rates and duration, and highlights the need for robust and high-quality epidemiology data to help inform public health interventions. Supplementary Information The online version contains supplementary material available at 10.1007/s40121-021-00534-3.

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Detection of influenza B viruses with reduced sensitivity to neuraminidase inhibitor in Morocco during 2014/15 season

Cited by 4 publications

References 14 publications

A Snapshot of Influenza Surveillance, Vaccine Recommendations, and Vaccine Access, Drivers, and Barriers in Selected Middle Eastern and North African Countries

A Snapshot of Influenza Surveillance, Vaccine Recommendations, and Vaccine Access, Drivers, and Barriers in Selected Middle Eastern and North African Countries

Chimeric Hemagglutinin Constructs Induce Broad Protection against Influenza B Virus Challenge in the Mouse Model

A Systematic Review of Influenza Epidemiology and Surveillance in the Eastern Mediterranean and North African Region

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