Detection of infectious and toxigenic bacteria

Deisingh, Anil K.; Thompson, Michael

doi:10.1039/b109895k

Cited by 114 publications

(73 citation statements)

References 144 publications

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“…The ultimate goal would be to create a one nanoparticle-one bacterium or one nanoparticle-one protein type sensor system that does not rely on PCR or catalytic antibodies but upon simple suitably functionalized nanoparticles to detect disease and serum imbalances. [103] …”

Section: Nanoparticle-ppe Constructs: Novel Materialsmentioning

confidence: 97%

Poly(aryleneethynylene)s

Bunz

2009

Macromol. Rapid Commun.

210

172

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Poly(aryleneethynylene)s (PAE) are easily synthesized, chemically stable, and color-responsive towards their surroundings. These superbly chromic polymers are attractive as active transducers in sensors and advanced organic electronic devices. PAEs are generally fluorescent with emission maxima ranging from 420-600 nm, and can be either water- or organo-soluble. PAEs from linear building blocks are rigid rod molecules and display a host of supramolecular arrangements in solution and in the solid state. The poly(para-phenyleneethynylene)s (PPE) are lyotropic or thermotropic smectic liquid crystalline. In the solid state, PPEs display lamellar supramolecular structures that lead to distinct stranded nanoscale morphologies. The spectroscopy and the optical properties of the PAEs and in particular of the PPEs are dominated by their conformation, which is influenced by solid-state packing, solvent, temperature and other factors. The presence of twisted and planar forms and their interconversion leads to attractive structure/property relationships; PAEs are of use as ingredients for advanced supramolecular materials.

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Section: Nanoparticle-ppe Constructs: Novel Materialsmentioning

confidence: 97%

Poly(aryleneethynylene)s

Bunz

2009

Macromol. Rapid Commun.

210

172

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“…More recently, molecular approaches, such as the PCR amplification and analyses of unique DNA sequences and/or 16S rRNA, have supplanted traditional microbiological methods because they are highly accurate, sensitive and take shorter time [5]. However, these assays require specialized instruments and still take several hours to perform.…”

Section: Biosensors For Biological Agentsmentioning

confidence: 98%

Ternary Monolayer Interfaces for Ultrasensitive and Direct Bioelectronic Detection of Nucleic Acids in Complex Matrices

2011

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Electrochemical nucleic acid biosensors have received considerable attention for the detection of biological agents. Control of the surface chemistry and coverage of the electrode transducer are essential for enhancing the performance of electrochemical DNA biosensors, and particularly for maximizing the hybridization efficiency and minimizing of nonspecific adsorption events. This review highlights recent advances and progress in the development of new surface chemistry approaches based on novel ternary DNA self-assembled monolayer (SAM)-interfaces using dithiols as new co-adsorbents/backfillers. The design and characterization of these powerful ternary SAM interfaces on different gold transducers are described, along with their implications to electrochemical biosensing of bioagents.

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“…These methods require isolation and/or culturing of large quantities of the infectious agents, and therefore the analysis requires several days to be completed. More recently, molecular approaches, such as the polymerase chain reaction (PCR) amplification and analysis of unique DNA sequences and/or rRNA, have supplanted traditional microbiological methods because they are highly accurate and sensitive, and take less time [12]. However, these assays require specialized instruments and still take several hours to be performed.…”

Section: Introductionmentioning

confidence: 98%

Magnetic Beads‐Based Electrochemical Sensors Applied to the Detection and Quantification of Bioterrorism/Biohazard Agents

2011

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Nowadays, detecting the presence of bioterrorism and biohazard agents in environmental and food samples is of great concern, due to their toxicity, and because many of them are prone to be used in terrorism attacks. The use of functionalized magnetic beads (MBs) in the development of electrochemical immuno-and genosensors has resulted in innovative and powerful detection strategies that may be applied to environmental, food and clinical analysis. This review describes current research on the combination of functionalized MBs with electrochemical detection for the development of magnetobiosensors applied to rapid, sensitive and specific detection of bioterrorism and biohazard agents.

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Detection of infectious and toxigenic bacteria

Cited by 114 publications

References 144 publications

Poly(aryleneethynylene)s

Poly(aryleneethynylene)s

Ternary Monolayer Interfaces for Ultrasensitive and Direct Bioelectronic Detection of Nucleic Acids in Complex Matrices

Magnetic Beads‐Based Electrochemical Sensors Applied to the Detection and Quantification of Bioterrorism/Biohazard Agents

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