Detection of immune complexes in acute rheumatic fever and their relationship to HLA-B5.

Yoshinoya, S; Pope, Richard M.

doi:10.1172/jci109643

Cited by 54 publications

(21 citation statements)

References 37 publications

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“…Observou-se que complexos imunes circulantes estão presentes na maioria dos pacientes com FR aguda (34) , podendo-se sugerir que fragmentos de C4 de alótipos A6 estariam envolvidos na ineficiente solubilização e opsonização de complexos imunes estreptocócicos, sendo um fator a mais de predisposição para as seqüelas cardíacas imunopatológicas da DCR. Enquanto a participação de antígenos das classes I e II do MHC na interação celular da resposta imunológica na FR é um conceito já estabelecido, alótipos de complemento poderiam exercer uma função regulatória em diferentes estágios da doença, desde o reconhecimento dos antígenos estreptocócicos até a efetiva eliminação pelo sistema efetor humoral específico.…”

Section: Discussionunclassified

Associação do alótipo raro C4A6 do sistema complemento com a doença cardíaca reumática

Messias-Reason¹,

Cavalcanti²,

Radominski³

2004

Rev. Bras. Reumatol.

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RESUMOObjetivo: determinar se os alótipos do Fator B (BF), C2 e C4 (C4A e C4B) do sistema complemento poderiam ser marcadores para a doença cardíaca reumática (DCR) na população brasileira. Métodos: foram estudados 49 pacientes com DCR crônica. Os controles incluíram 65 indivíduos saudáveis, não aparentados, pareados com a amostra dos pacientes de acordo com o sexo, idade e grupo racial. Os alótipos de BF, C2, C4A e C4B foram determinados por técnicas-padrão, incluindo Western blot para a determinação das variantes de C2 e C4, utilizando-se anticorpos monoclonais e policlonais. Resultados: este estudo demonstrou um significante aumento do alelo raro C4A*6 (p=0,003 RR=11,85) e diminuição de C4A*3 nos pacientes, quando comparados com os controles. Além disso, alelos nulos de C4 e raros de C4 e BF foram observados com maior freqüência nos pacientes. Conclusões: considerando-se que foram avaliados somente pacientes com DCR, mais estudos serão necessários para que se possa esclarecer se o alelo C4A6 pode ser um marcador da forma cardíaca ou da própria doença.

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Section: Discussionunclassified

Associação do alótipo raro C4A6 do sistema complemento com a doença cardíaca reumática

Messias-Reason¹,

Cavalcanti²,

Radominski³

2004

Rev. Bras. Reumatol.

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“…As indicated in Table 2, prednisolone suppressed EC proliferation in a dosedependent manner, whereas aspirin had little effect on EC proliferation within the concentrations tested. sooo cpm x 10-1 detects complement fixing immune complexes, the mRF assay detects both complement-fixing and noncomplement fixing immune complexes (10)(11)(12), and the red cell assay detects C3-bound complexes (13). Our results strongly suggest that patients with this disease do not possess significant levels of circulating immune complexes.…”

Section: Discussionmentioning

confidence: 99%

“…Three radioimmunoassays to detect immune complexes were performed as previously described (10)(11)(12)(13). Briefly, the Clq-solid phase (Clq-SP) and the monoclonal rheumatoid factor-solid phase (mRF-SP) assays were performed by coating polystylene tubes with 0.5 ml isolated Clq (5 JIg/ml) or mRF (85 JIg/ml) for 16 h at 4 0 C. Remaining binding sites were blocked with 1% of bovine serum albumin in PBS contain--ing 1'0 mM-EDTA (5 mM sodium phosphate, 0.15 M sodium chloride, 10 mM EDTA, pH 8.0) (BSA-PBSE).…”

mentioning

confidence: 99%

Enhanced Endothelial Cell Proliferation in Acute Kawasaki Disease (Muco-Cutaneous Lymph Node Syndrome)

et al. 1986

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“…Research shows that artificially synthesise interleukins had been used in treatment of the following; post surgery in patient with chronic hepatitis B infection [21], in HIV infection [22], in cancer treatment [23]. Findings also shows the relation of fever and immune response [24] and hyperthermia [25] physioanatobiochemical processes [26].…”

Section: Physioanatomical Roles Of the Immune System Entities In Longmentioning

confidence: 99%

A Novel Automated Immune Boosting Machine (Blueprint Glimpse) Which May Increase Life Span and Insight into Unexploited Benefits of Febrile Responses (Fever)

Sani¹

2015

J Med Diagn Meth

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Definition of new termsSpecial treatment room is a specially designed room in the hospital where the machine will be house. VBBI is values of strength of the immune systems following exposure to the machine, ISI is the immune strength time span. IP is immune power actual ability of immune system to fight off or attenuate an attack. AbstractThe essence of the review is to demonstrate the following, the evolution of a novel machine that could boost the body immune system, treat through hyperthermia, existing body abnormalities linked with febrilar response, and make formidable the immune system if routine weekly exposure of individuals, whether or not in ill health is done, and again the operation of the machine will focus on adjustment of bio-thermal circles pertinent to induced pyrogen (for routine treatment) and non-induce non-pyrogen (as found in ill health) such that immediate immune response effectively, could combat existing disease in addition to protecting the body against futures attacks generally. Febrile responses mediators, broadly speaking encompass dual types, pyrogens and non-pyrogen, pyrogens mediated are inducible even in absence of disease or abnormal condition, non pyrogen febrilar reponses usually emanate from disease or abnormal condition of the body (cancer, infectious disease and non infectious disease) in either case, resultant hypethermia and immune responses are secondary to altered cellular physiological processes, among them are increases or decrease in metabolism of fuels molecules of the cells, mobilisation of mineral elements iron for instance, acute phase protein mobilisation, increase in uptake of de novo synthesize survival materials (may increase life span), activations of immune system chain reaction by secretion of immunological communicants such as cytokines and chemokines, sensitization and recruitment of other immune cells, ultimately also includes interactions between autocoids and some immunes cells, and as determined by the hypothalamic thermostat leading to increase in body defence mechanism and well being. Erroneously, temperature increase is seen as fever, however on the contrary, hyperthermal events is just one among many of it manifestations, for actually fever is systemic attempts to fight off pathological or abnormal attacks in the internal milieu, past finding adduced that fever is associated with many disease or abnormality, a fact that depict a need for further research on survival value of fever, it has survival value (Kluger 1998), results obtained using mathematical methods in a novel way from previous finding results and standard reference physioantobiochemical values were analysed with SPSS analytical package, dependent variables (Immune Strength Index (ISI), Values of Boosted Body Immunity (VBBI), PARPS, Survival values, Life span increase) and independent variables (incremental values of febrile temperature values of pyrogen used, number of exposure to the machine) show strong correlation P ≤ 0.005, temperature and survival value (increase in life span)...

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Detection of immune complexes in acute rheumatic fever and their relationship to HLA-B5.

Cited by 54 publications

References 37 publications

Associação do alótipo raro C4A6 do sistema complemento com a doença cardíaca reumática

Associação do alótipo raro C4A6 do sistema complemento com a doença cardíaca reumática

Enhanced Endothelial Cell Proliferation in Acute Kawasaki Disease (Muco-Cutaneous Lymph Node Syndrome)

A Novel Automated Immune Boosting Machine (Blueprint Glimpse) Which May Increase Life Span and Insight into Unexploited Benefits of Febrile Responses (Fever)

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