Detection of IL-5 and IL-1 receptor antagonist in bronchoalveolar lavage fluid in acute eosinophilic pneumonia

Allen, James N.; Liao, Zhiming; Wewers, Mark D.; Altenberger, Elizabeth A.; Moore, S A; Allen, Edward D.

doi:10.1016/s0091-6749(96)70206-3

Cited by 57 publications

(50 citation statements)

References 43 publications

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“…These studies suggested that IL-5 may become detectable as asthma progresses to a symptomatic state. However, there have been only a few detailed reports demonstrating that high IL-5 levels were detected in BALF from ILD [16,31]. In the present study, IL-5 was detected only in BALF of patients with EP.…”

Section: Discussioncontrasting

confidence: 57%

Interleukin 5 and granulocyte-macrophage colony-stimulating factor levels in bronchoalveolar lavage fluid in interstitial lung disease

Taniguchi¹,

Katoh²,

Kadota³

et al. 2000

European Respiratory Journal

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Section: Discussioncontrasting

confidence: 57%

Interleukin 5 and granulocyte-macrophage colony-stimulating factor levels in bronchoalveolar lavage fluid in interstitial lung disease

Taniguchi¹,

Katoh²,

Kadota³

et al. 2000

European Respiratory Journal

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“…Although IL-5 levels were higher in CEP patients than those in the CTL group and significantly correlated with the percentage of eosinophils (figs. 2 and 3, table 2), the levels in BAL fluid were relatively low when compared to those previously reported in patients with eosinophilic pneumonia [24,25]. Previous reports described high IL-5 levels in BAL fluid, mainly in acute eosinophilic pneumonia.…”

Section: Discussionmentioning

confidence: 49%

Eotaxin and monocyte chemoattractant protein-1 in chronic eosinophilic pneumonia

Tateno¹,

Nakamura²,

Minematsu³

et al. 2001

Eur Respir J

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Chronic eosinophilic pneumonia (CEP) is characterized by chronic or recurrent pulmonary infiltrates with eosinophils, but the precise mechanism of eosinophil accumulation has not been fully elucidated. Eotaxin is one of the CC chemokines that selectively recruits eosinophils and contributes to the pathogenesis of allergic airway diseases including asthma, but its roles in pathogenesis of CEP have not been fully elucidated.The authors measured concentrations of eotaxin and other CC chemokines, monocyte chemoattractant protein-1 (MCP-1), regulated on activation, normal T-cell expressed and secreted, macrophage inflammatory protein-1a, and the eosinophil activating Th2 cytokine interleukin (IL)-5 in bronchoalveolar lavage (BAL) fluid from CEP patients (n~11), and compared these concentrations with those from control subjects (n~6).The eotaxin (904¡203 versus 29¡7 pg?mL -1 , p~0.0001), MCP-1 (194¡57 versus 15¡2 pg?mL -1 , pv0.05), and IL-5 (7.8¡2.0 versus 2.7¡0.6 pg?mL -1 , pv0.05) levels were significantly higher for cases with CEP in comparison to those serving as controls. Proportions of eosinophil and lymphocyte counts were greater in BAL fluid from CEP patients. Eotaxin and IL-5 levels correlated with the proportion of eosinophils in BAL fluid from CEP patients. MCP-1 correlated with the relative lymphocyte numbers.In short, eotaxin, interleukin-5, and monocyte chemoattractant protein-1 levels were higher in the BAL fluid of CEP patients and these levels may contribute to eosinophil and lymphocyte recruitment and activation in the airways as found with this disorder. Eur Respir J 2001; 17: 962-968.

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“…The number of reports describing AEP cases has recently increased and several of these have demonstrated the elevation of IL-5 levels in serum and BAL fluid [4][5][6]. Some reports have described the role of IL-5 in the pathogenesis or disease activity of AEP [4,17]. IL-5 is particularly implicated in the development of eosinophilic inflammation, because it is involved in the promotion of the growth, maturation, migration, increased survival, recruitment, local infiltration, and activation of eosinophils, and enhances the release of mediators [7,8,18].…”

Section: Discussionmentioning

confidence: 99%

Increased vascular endothelial growth factor in acute eosinophilic pneumonia

Nishigaki

Fujiuchi²,

Yamazaki³

et al. 2003

Eur Respir J

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Acute eosinophilic pneumonia (AEP) is associated with the presence of diffuse pulmonary infiltrates on the chest radiograph and an increased number of eosinophils and an elevation of interleukin (IL)-5 levels in bronchoalveolar lavage (BAL) fluid. Vascular endothelial growth factor (VEGF) is a constitutively expressed protein encoded by messenger ribonucleic acid in human eosinophils and is released following stimulation with IL-5. However, the roles of IL-5 and VEGF in the pathogenesis or activity of this disease have not been clarified.The authors investigated the cells and the levels of these two factors in BAL fluid in five AEP patients and five normal controls before and after corticosteroid treatment.The absolute number of eosinophils?mL -1 , IL-5 and VEGF levels in patients before treatment were higher than in controls (53.8 versus 0.3610 4 ?mL -1 , 490.1 versus 5.2 pg?mL -1 and 643.0 versus 133.9 pg?mL -1 , respectively). IL-5 and VEGF rapidly decreased to the control level in parallel with clinical improvement. The relationship between eosinophilia and IL-5 and VEGF levels was strongly significant.Elevated interleukin-5 in the lung may initiate the recruitment of eosinophils and enhance the release of mediators, such as vascular endothelial growth factor from eosinophils, which, in turn, increases the permeability of blood vessels. Eur Respir J 2003; 21: 774-778.

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Detection of IL-5 and IL-1 receptor antagonist in bronchoalveolar lavage fluid in acute eosinophilic pneumonia

Cited by 57 publications

References 43 publications

Interleukin 5 and granulocyte-macrophage colony-stimulating factor levels in bronchoalveolar lavage fluid in interstitial lung disease

Interleukin 5 and granulocyte-macrophage colony-stimulating factor levels in bronchoalveolar lavage fluid in interstitial lung disease

Eotaxin and monocyte chemoattractant protein-1 in chronic eosinophilic pneumonia

Increased vascular endothelial growth factor in acute eosinophilic pneumonia

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