DETECTION OF IgG ANTIBODIES TO LYMPHADENOPATHY-ASSOCIATED VIRUS IN PATIENTS WITH AIDS OR LYMPHADENOPATHY SYNDROME

High prevalence of antibodies to acquired immune deficiency syndrome (AIDS)-associated retrovirus (ARV) in AIDS and related conditions but not in other disease states.

“…Antiviral antibodies were also found at high frequency in AIDS-related disease states and sexual contacts of AIDS patients. A lower, but substantial, number of clinically healthy homosexual men also had antibodies to ARV, as has been reported (6,(17)(18)(19)(20). In the control population, none of 743 healthy individuals tested were positive for ARV antibody.…”

“…HUT-78 cells were sedimented at 2000 rpm for 5 min at 40C, washed in 10 ml of cold phosphate-buffered saline, and resuspended in phosphate-buffered saline at 106 cells per ml. Aliquots (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) …”

Acquired immunodeficiency syndrome: More than a health-related dilemma

“…In their discussion of these early reports, the CDC editors noted that the homosexual males involved seemed to (i) The disease parameters have been defined (19,22) and redefined for adults (40,83) and children (25,31,38). These studies allow epidemiological tracking of the disease (13,54,85).…”

“…(v) Screening procedures suitable for identifying antibody to HIV in body fluids have been developed (43,72,81,112,115) and have been used for screening high-risk population members (13,28), blood and blood products (27), military applicants (14,44), and peniteniary populations (32).…”

Prix Nobel de Médecine 2008 (Françoise Barré-Sinoussi et Luc Montagnier) : Une vie consacrée à combattre le Sida

“…Rebaptisé HIV-1 (human immuno deficiency virus type 1) en 1985, ce virus appartient au genre des lentivirus de la famille des rétrovi-rus, groupe qui contient des virus associés à une virémie persistante chez les singes, les chats, les chevaux, les bovins et les chèvres. Cette découverte en entraîna beaucoup d'autres dans les mois qui suvirent : mise au point d'un test de dépistage [4], identification du CD4 comme récepteur du virus [5], description de la séquence du virus [6], ouvrant la voie à la mise au point d'anti-rétroviraux. Vingt-cinq ans après cette découverte, ONUSIDA estime à 33 millions (avec un intervalle plausible de 30 à 36) le nombre de personnes vivant avec le VIH à la fin de 2007, avec 2,5 millions nouvelles infections et 2 millions de décès en 2007 [7].…”