Detection of<i>Mycobacterium tuberculosis</i>Group Organisms in Human and Mouse Joint Tissue by Reverse Transcriptase PCR: Prevalence in Diseased Synovial Tissue Suggests Lack of Specific Association with Rheumatoid Arthritis

Kempsell, Karen E.; Cox, Charles; McColm, Andrew A.; Bagshaw, Julie A.; Reece, Richard J.; Veale, Douglas J.; Emery, Paul; Isaacs, John D.; Gaston, J. S. H.; Crowe, Jenny

doi:10.1128/iai.69.3.1821-1831.2001

Cited by 21 publications

(10 citation statements)

References 58 publications

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“…In addition, this association was strengthened after the observation of a seronegative form of oligoarthritis following immunotherapy with Bacillus Calmette–Guerin (BCG) vaccine [ 68 ]. Various studies have shown the presence of mycobacterium antigens in RA patients’ joints [ 69 , 70 , 71 , 72 ]. Moreover, increased levels of Abs against Mycobacterium in the serum [ 73 , 74 , 75 ] and the presence of active T cells in the synovium have been reported in RA patients [ 76 , 77 ].…”

Section: The Role Of Mycobacterial Infections In Rheumatoid Arthrimentioning

confidence: 99%

Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria

Jasemi

Uras

et al. 2020

Microorganisms

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Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by chronic erosive polyarthritis. A complex interaction between a favorable genetic background, and the presence of a specific immune response against a broad-spectrum of environmental factors seems to play a role in determining susceptibility to RA. Among different pathogens, mycobacteria (including Mycobacterium avium subspecies paratuberculosis, MAP), and Epstein–Barr virus (EBV), have extensively been proposed to promote specific cellular and humoral response in susceptible individuals, by activating pathways linked to RA development. In this review, we discuss the available experimental and clinical evidence on the interplay between mycobacterial and EBV infections, and the development of the immune dysregulation in RA.

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Section: The Role Of Mycobacterial Infections In Rheumatoid Arthrimentioning

confidence: 99%

Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria

Jasemi

Uras

et al. 2020

Microorganisms

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“…TI was very common in Europe in the eighteenth century and would by chance occur among those with different rheumatic diseases. However, the possibility of interactions between the immunopathogenesis of RA and the immune response to TI has long been under consideration, and needs further elucidation (13). A high prevalence of TI in the population has been suggested to induce in future generations a genetically based disposition for the development of RA, concomitant with an increased resistance against TI (14).…”

Section: Discussionmentioning

confidence: 98%

A case of chronic polyarthritis with début in 1771: rheumatoid arthritis or Poncet's disease?

Hansén¹,

Wallenquist²

2007

Scandinavian Journal of Rheumatology

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“…In addition, guttate psoriasis is associated with streptococcal infections [12,13]. A recent study using sensitive reverse transcriptase polymerase chain reaction (PCR) analysis demonstrated the presence of numerous mycobacterial organisms in the joints of patients with RA, suggesting they may occur without causing arthritis [14].…”

Section: T-cell Activationmentioning

confidence: 99%

Pathways of cell activation in spondyloarthropathies

Fearon

Veale

2001

Curr Rheumatol Rep

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The initiating event in cell activation is unknown in most autoimmune diseases. The role of infection is clear in some cases, especially in reactive arthritis; however, there is little evidence of a specific organism in other spondyloarthropathies. Common pathways of cell-cell interaction and activation manifest in inflammation, but subtle differences may exist. The presence of T cells, macrophages, and B-lymphocytes suggest an autoimmune mechanism; the arthritogenic peptide theory has been proposed. Furthermore, the association of spondyloarthropathies with HLA-B27 suggests it may be important in synovial T-cell activation. Other cell types involved in the process of bone and cartilage destruction, including fibroblasts and osteoclasts, may also be activated. Endothelial activation and angiogenesis may be a critical primary event in these diseases. Finally, trauma (physical or psychological) in the form of stress may be an important factor; the nervous system and neuropeptides may play a role in cell activation and initiation of arthritis.

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Detection ofMycobacterium tuberculosisGroup Organisms in Human and Mouse Joint Tissue by Reverse Transcriptase PCR: Prevalence in Diseased Synovial Tissue Suggests Lack of Specific Association with Rheumatoid Arthritis

Abstract: Infection with mycobacterial species, including

Cited by 21 publications

References 58 publications

Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria

Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria

A case of chronic polyarthritis with début in 1771: rheumatoid arthritis or Poncet's disease?

Pathways of cell activation in spondyloarthropathies

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