2020
DOI: 10.1007/978-1-0716-1028-2_20
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Detection of Hypoxic Regions in the Bone Microenvironment

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Cited by 1 publication
(2 citation statements)
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“…In case specific cell subpopulations have varying luciferase expression, this variation might be enhanced in special growth conditions (e.g. : exposure to hypoxia, composition of the tumor microenvironment [ 36 , 37 ]), where only a highly specialized subpopulation of DTCs might be able to survive and initiate metastatic growth. To this end, we could at least exclude variations in the percentages of Luciferase-positive tumor cells per metastasis in lung vs. bone (observational data only; representative images can be seen in Figs.…”
Section: Discussionmentioning
confidence: 99%
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“…In case specific cell subpopulations have varying luciferase expression, this variation might be enhanced in special growth conditions (e.g. : exposure to hypoxia, composition of the tumor microenvironment [ 36 , 37 ]), where only a highly specialized subpopulation of DTCs might be able to survive and initiate metastatic growth. To this end, we could at least exclude variations in the percentages of Luciferase-positive tumor cells per metastasis in lung vs. bone (observational data only; representative images can be seen in Figs.…”
Section: Discussionmentioning
confidence: 99%
“…The use of luciferase mutants with bioluminescent properties that enable dual-color reporter assays has therefore been suggested [ 40 ]. Bone in particular has been considered a hypoxic environment [ 41 ] and might thus, in addition to hypoxic tumor regions, influence the obtained BLI signal intensity [ 37 , 42 , 43 ]. This could be another reason why the quantification of bone metastasis load by BLI is less accurate in bone compared to lung tissues.…”
Section: Discussionmentioning
confidence: 99%