Detection of hydrogen sulfide using BODIPY based colorimetric and fluorescent on-off chemosensor

Paul, Navendu; Sarkar, Rudra; Sarkar, Ripon; Barui, Ananya; Sarkar, Sabyasachi

doi:10.1007/s12039-019-1724-4

Cited by 14 publications

(6 citation statements)

References 44 publications

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“…Using a similar platform, Sarkar reported 31, which resulted in a turn-off fluorescence at 516 nm in 33% MeOH in buffer. 119 This fluorescence turn-off response was selective for H 2 S over other biologically relevant anions. This probe was used to develop H 2 S test strips and the turn-off response to exogenous H 2 S was confirmed in normal human oral fibroblast cells.…”

Section: −mentioning

confidence: 91%

Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

Fosnacht,

Pluth

2024

Chem. Rev.

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Hydrogen sulfide (H 2 S) is not only a well-established toxic gas but also an important small molecule bioregulator in all kingdoms of life. In contemporary biology, H 2 S is often classified as a "gasotransmitter," meaning that it is an endogenously produced membrane permeable gas that carries out essential cellular processes. Fluorescent probes for H 2 S and related reactive sulfur species (RSS) detection provide an important cornerstone for investigating the multifaceted roles of these important small molecules in complex biological systems. A now common approach to develop such tools is to develop "activitybased probes" that couple a specific H 2 S-mediated chemical reaction to a fluorescent output. This Review covers the different types of such probes and also highlights the chemical mechanisms by which each probe type is activated by specific RSS. Common examples include reduction of oxidized nitrogen motifs, disulfide exchange, electrophilic reactions, metal precipitation, and metal coordination. In addition, we also outline complementary activity-based probes for imaging reductant-labile and sulfane sulfur species, including persulfides and polysulfides. For probes highlighted in this Review, we focus on small molecule systems with demonstrated compatibility in cellular systems or related applications. Building from breadth of reported activity-based strategies and application, we also highlight key unmet challenges and future opportunities for advancing activity-based probes for H 2 S and related RSS.

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Section: −mentioning

confidence: 91%

Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

Fosnacht,

Pluth

2024

Chem. Rev.

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“…A distinct color change of L solution from colorless to bluish-purple took place after treatment with H 2 S. Using this probe, they detected H 2 S vapor, H 2 S in water and wine samples, and H 2 S imaging in live MCF-7 cells. Besides, Paul et al [ 78 ] reported a colorimetric and fluorescence turn-off probe 10-(4-azido phenyl)-5,5-difluoro-5h-dipyrrolo[1,2-c:1′,2′-f] [ 1 – 3 ] diazaborinin-4-ium-5-uide, 1, for selective detection of H 2 S. The detection limit of this probe was 0.17 μ M for H 2 S. They successfully detected exogenous H 2 S in live normal human oral fibroblast (NHOF) cells.…”

Section: Dual-mode Detection For Live Cell Analysismentioning

confidence: 99%

Analytical Methods for Detection of Gasotransmitter Hydrogen Sulfide Released from Live Cells

Quan

Lee

2021

BioMed Research International

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Hydrogen sulfide (H2S) plays an important role in mammals as a signaling molecule. Recently, abnormal H2S concentration has been associated with several pathophysiological states, such as diabetes mellitus, hypertension, Alzheimer’s disease, and Parkinson’s disease. As regulating H2S concentration can be a very prominent way of developing new drugs, many researchers have paid great attention to H2S research. To understand the role of H2S in pathophysiology and develop H2S-based therapies, it is necessary to measure the exact concentration of H2S within biological systems. But, H2S is volatile and can be easily oxidized. Besides, the active sites for several biological effects of H2S are inside the cell. Therefore, there is a need for the development of new methods for the accurate and reliable detection of H2S within live cells. This review provides a summary of recent developments in H2S detection methods for live cell analysis.

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“…A similar strategy was also used for the detection of H 2 S in the presence of CO [14] . Others quenching methods involves levulinate [15] and aromatic diamine [16] which are easily and selectively reacted with sulfite [15] and NO [16] , respectively.…”

Section: Bodipy-based Gas Probesmentioning

confidence: 99%

Gas probes and their application in gas therapy

Gong¹,

Yu²,

He³

2021

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As an emerging field, gas therapy attracts increasing attention because of its distinguishing features in disease treatment. However, to achieve a therapeutic effect, the concentration of gas should be carefully controlled. Thus, a suitable and convenient technology is required to monitor the gas concentration in vivo. Besides, the transportation of gas into human body and in vivo biodistribution of gas also need to be evaluated. Among the technologies adopted in gas therapy, fluorescence imaging technology is the first choice due to its high specificity, high sensitivity, and non-invasion. And as the core of fluorescence imaging, the properties of fluorescent dyes directly determine the quality of imaging. So, it is critical to choose suitable gas probes for different purposes. Here, we review common gas detection methods, including a brief introduction of fluorescence, the distinctive properties of five fluorophore cores, and the detection mechanisms of common gas probes. Then, the applications of gas probes in gas delivery, gas release, and gas therapy are summarized. At last, we discuss the potential of developing further intelligent gas probes and fluorescence imaging technologies for gas therapy.

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Detection of hydrogen sulfide using BODIPY based colorimetric and fluorescent on-off chemosensor

Cited by 14 publications

References 44 publications

Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

Analytical Methods for Detection of Gasotransmitter Hydrogen Sulfide Released from Live Cells

Gas probes and their application in gas therapy

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