Detection of Hydrochlorothiazide, Sulfamethoxazole, and Trimethoprim at Metal Oxide Modified Glassy Carbon Electrodes

Khanfar, Mohammad F.

doi:10.20964/2020.02.35

Cited by 10 publications

(9 citation statements)

References 49 publications

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“…The various techniques available for the selective and sensitive detection of HCTZ include HPLC, capillary zone electrophoretic, spectrophotometric/HPLC and electrochemical methods [6][7][8][9][10][11]. Electrochemistrybased methods can be employed considering their lower cost, speediness, portability, reasonable selectivity, simple preparation process, suitable accuracy, and precision for the analysis of biological compounds, gas pollutants, drugs, food and water pollutants compounds [12][13][14][15][16][17][18][19][20][21][22].…”

Section: A D V N C E D O N L I N E a R T I C L Ementioning

confidence: 99%

Voltammetric determination of hydrochlorothiazide at a modified carbon paste electrode with polypyrrole nanotubes

Mohammadnavaz

Garkani

2023

ADMET DMPK

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In this paper, the electrochemical behavior of hydrochlorothiazide (HCTZ) is described using carbon paste electrodes modified with polypyrrole nanotubes (PPy-NTs/CPEs) at pH value 7. Experiments revealed that the presence of HCTZ greatly impacts the electrochemical behavior of modified CPEs. The synthesized PPy-NTs were utilized as a sensing material for the electrochemical detection of HCTZ and were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry. The key experiment conditions, including supporting electrolyte and electrolyte pH, were studied and optimized. Under optimized conditions, the prepared sensor displayed the linear relationships for the concentrations of HCTZ from 5.0 to 400.0 μM (R2 = 0.9984). The detection limit of the PPy-NTs/CPEs sensor was found to be 1.5 μM using the DPV method. The PPy-NTs is highly selective, stable and sensitive for the determination of HCT. Therefore, we believe the newly prepared PPy-NTs material can be useful for different electrochemical applications.

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Section: A D V N C E D O N L I N E a R T I C L Ementioning

confidence: 99%

Voltammetric determination of hydrochlorothiazide at a modified carbon paste electrode with polypyrrole nanotubes

Mohammadnavaz

Garkani

2023

ADMET DMPK

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“…These are interesting features when compared with other commonly employed electrodes in sensor fabrication, as evidenced in a recent review [ 21 ]. Concerning trimethoprim, some sensors have been developed based on more traditional electrodes such as glassy carbon (GCE) [ 22 , 23 , 24 , 25 , 26 , 27 , 28 ] or boron-doped diamond (BDD) electrode [ 29 , 30 , 31 ], but also screen-printed [ 32 , 33 ] and carbon paste [ 34 ] were employed ( Table 1 ). Considering all these sensors, none were employed in challenging solid food samples, such as fish, which was tested for the first time in this study.…”

Section: Introductionmentioning

confidence: 99%

Carbon Fiber Paper Sensor for Determination of Trimethoprim Antibiotic in Fish Samples

Torrinha

Tavares

Dibo

et al. 2023

Sensors

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The increase in anthropogenic pollution raises serious concerns regarding contamination of water bodies and aquatic species with potential implications on human health. Pharmaceutical compounds are a type of contaminants of emerging concern that are increasingly consumed and, thus, being frequently found in the aquatic environment. In this sense, an electrochemical sensor based on an unmodified and untreated carbon fiber paper (CPS—carbon paper sensor) was simply employed for the analysis of trimethoprim antibiotic in fish samples. First, the analytical conditions were thoroughly optimized in order for the CPS to achieve maximum performance in trimethoprim determination. Therefore, an electrolyte (0.1 M Britton–Robinson buffer) pH of 7 was selected and for square wave voltammetry parameters, optimum values of amplitude, frequency and step potential corresponded to 0.02 V, 50 Hz, and 0.015 V, respectively, whereas the deposition of analyte occurred at +0.7 V for 60 s. In these optimum conditions, the obtained liner range (0.05 to 2 µM), sensitivity (48.8 µA µM−1 cm−2), and LOD (0.065 µM) competes favorably with the commonly used GCE-based sensors or BDD electrodes that employ nanostructuration or are more expensive. The CPS was then applied for trimethoprim determination in fish samples after employing a solid phase extraction procedure based on QuEChERS salts, resulting in recoveries of 105.9 ± 1.8% by the standard addition method.

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“…This drug lowers blood pressure and has a protective effect on the heart, brain, and kidneys. , Abrupt discontinuation of this drug may cause harm to the body; sometimes doctors recognize that it should be used for the rest of your life . Hydrochlorothiazide (HCTZ, Figure ) is a thiazide diuretic that decreases the amount of water in the body by increasing urine flow . The mechanism of action of hydrochlorothiazide is not exactly known, but it is thought that the removal of excess salt and water from the body by this drug reduces the difficulty of pumping the heart and reduces blood pressure and swelling .…”

Section: Introductionmentioning

confidence: 99%

“…The mechanism of action of hydrochlorothiazide is not exactly known, but it is thought that the removal of excess salt and water from the body by this drug reduces the difficulty of pumping the heart and reduces blood pressure and swelling . HCTZ may be used to prevent kidney stones , and treat diabetes insipidus and edema caused by various diseases . A combination of two drugs, AML and HCTZ, can be widely used to reduce or control blood pressure. − …”

Section: Introductionmentioning

confidence: 99%

Introduction of AlV₃O₉/CNT Nanocomposite for Modification of the Electrochemical Sensor in Order the Determination of Amlodipine and Hydrochlorothiazide in Biological and Pharmaceutical Samples

Ziaie

Shabani-Nooshabadi

2022

Ind. Eng. Chem. Res.

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A novel voltammetric sensor based on a carbon paste electrode modified (CPE) with AlV 3 O 9 /CNT nanocomposite (AlV 3 O 9 /CNT/CPE) was developed for the determination of two important and effective drugs namely amlodipine (AML) and hydrochlorothiazide (HCTZ). Due to the importance of monitoring these drugs, a new electrochemical sensor has been developed using a carbon paste electrode modified with AlV 3 O 9 / CNT nanocomposite (AlV 3 O 9 /CNT/CPE) . Electrode charge transfer resistances were evaluated by impedance electrochemical spectroscopy (EIS). In phosphate buffer (pH 7.0), AML and HCTZ exibilted an irreversible oxidation peak at about 0.65 and 0.85 V vs Ag/AgCl (3 M KCl), respectively. In optimal conditions, the detection limits of AML and HCTZ in the concentration range of 0.90−90.00 nM were 26.00 nM and 25.00 nM, respectively. Finally, the chronoamperometry method was used to compute the diffusion coefficients (D) of AML and HCTZ on the surface of AlV 3 O 9 /CNT/CPE. Based on the results, the CPE modified with AlV 3 O 9 /3%CNT nanocomposite can be successfully used to determine AML and HCTZ in the pharmaceutical formulation of tablets and real samples including blood and urine serums. Simultaneous measurement of AML and HCTZ was performed by the proposed sensor without interference.

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Detection of Hydrochlorothiazide, Sulfamethoxazole, and Trimethoprim at Metal Oxide Modified Glassy Carbon Electrodes

Cited by 10 publications

References 49 publications

Voltammetric determination of hydrochlorothiazide at a modified carbon paste electrode with polypyrrole nanotubes

Voltammetric determination of hydrochlorothiazide at a modified carbon paste electrode with polypyrrole nanotubes

Carbon Fiber Paper Sensor for Determination of Trimethoprim Antibiotic in Fish Samples

Introduction of AlV₃O₉/CNT Nanocomposite for Modification of the Electrochemical Sensor in Order the Determination of Amlodipine and Hydrochlorothiazide in Biological and Pharmaceutical Samples

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Detection of Hydrochlorothiazide, Sulfamethoxazole, and Trimethoprim at Metal Oxide Modified Glassy Carbon Electrodes

Cited by 10 publications

References 49 publications

Voltammetric determination of hydrochlorothiazide at a modified carbon paste electrode with polypyrrole nanotubes

Voltammetric determination of hydrochlorothiazide at a modified carbon paste electrode with polypyrrole nanotubes

Carbon Fiber Paper Sensor for Determination of Trimethoprim Antibiotic in Fish Samples

Introduction of AlV3O9/CNT Nanocomposite for Modification of the Electrochemical Sensor in Order the Determination of Amlodipine and Hydrochlorothiazide in Biological and Pharmaceutical Samples

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Introduction of AlV₃O₉/CNT Nanocomposite for Modification of the Electrochemical Sensor in Order the Determination of Amlodipine and Hydrochlorothiazide in Biological and Pharmaceutical Samples