Detection of human papillomaviruses of high oncogenic potential in oral squamous cell carcinoma in a Venezuelan population

Abstract

We observed a high prevalence of HPV infection of high oncogenic potential types in patients with SCC in our studied group. The moderately differentiated SCCs were more associated to HPV infection. These differences could be influenced by nutritional, environmental and genetical factors in our population but further studies should be carried out to determine these aspects.

Biopsy vs. brushing: Comparison of two sampling methods for the detection of HPV-DNA in squamous cell carcinoma of the oral cavity

“…The relationship between the histological grading of HNSCCs and HPV infection has been investigated in the literature, with controversial findings. Various authors have observed a significant frequency of HPV infection among G3 tonsillar SCCs, [49][50][51] and the same result was obtained by Sugiyama for OSCC 52 ; Higa et al 53 found an association of HPV infection with G1 OSCCs and Correnti et al 54 with G2 oral cancers. However, other authors have failed to report any association between HPV infection and grading score in both oral and oropharyngeal SCC.…”

The prevalence of human papillomavirus in the oropharynx in healthy individuals in a Brazilian population

“…A number of studies have addressed the prevalence of HPV DNA in malignant lesions of the oral cavity [Sand et al, 2000;Giovannelli et al, 2002;Ha et al, 2002;Correnti et al, 2004;Kurose et al, 2004]. However, HPV DNA has also been found in normal oral mucosa [Miller and Johnstone, 2001;Kurose et al, 2004].…”

“…HR types of HPV are a causative agent of uterine cervical cancer, and molecular biological approaches have provided evidence for specific mechanisms [zur Hausen, 1999]. An increasing number of studies have suggested that HR types of HPV play an etiological role in the pathogenesis of head and neck squamous cell carcinoma, particularly in oropharyngeal carcinomas and especially in tonsillar malignancies [Gillison and Shah, 2001;Miller and Johnstone, 2001;Giovannelli et al, 2002;Correnti et al, 2004;Smith et al, 2004b].…”

The adjunctive role of toluidine blue in detection of oral premalignant and malignant lesions

“…However, OSCC is becoming more common among younger patients [18][19][20][21][22][23][24][25][26] who may not have the traditional risk factors of tobacco, alcohol consumption [14,22,[27][28][29][30][31], and poor diet [31][32][33][34][35][36]. Human papilloma virus (HPV) has more recently been identified as a leading etiologic risk factor in oropharyngeal SCC [24,26,[37][38][39].…”