Detection of human papillomavirus L1 gene DNA  fragments in postmortem blood and spleen after Gardasil&amp;lt;sup&amp;gt;&amp;#174;&amp;lt;/sup&amp;gt; vaccination—A case report

Lee, Sin Hang

doi:10.4236/abb.2012.38148

Cited by 20 publications

(12 citation statements)

References 51 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current literature, there are numerous cases substantiating the link between adverse immune reactions and HPV vaccines, including fatal reactions. For example, Lee recently reported a case of a teenage girl who underwent sudden unexpected death approximately 6 months after her third Gardasil HPV vaccine booster. The patient experienced adverse manifestations shortly after the first dose of Gardasil injection (i.e.…”

Section: Discussionmentioning

confidence: 99%

Human Papilloma Virus Vaccine and Primary Ovarian Failure: Another Facet of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants

Colafrancesco

Perricone

Tomljenovic

et al. 2013

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Human Papilloma Virus Vaccine and Primary Ovarian Failure: Another Facet of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants

Colafrancesco

Perricone

Tomljenovic

et al. 2013

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

“…Nanoclusters of magnetized water and DNA, then, may act in concert to provide a supramolecular scaffolding acting to transmit both energy and information over long distances. Empirical evidence already cited shows that interfacial water stress (IWS) provides a supramolecular basis for both the formation and stability of rings of circular DNA [144], microDNAs [145], non-B-conformation DNA [146], and Z-DNA [147]. IWS and nanoclusters of magnetized water also provide a supramolecular basis for modulating DNA structural stability in both health, e.g., normal cell division, and disease, e.g., oncogenesis.…”

Section: Promoting Electrical Conductivity At Biological Interfacesmentioning

confidence: 99%

“…By binding with nucleic acids, Al interferes with intracellular protein metabolism [236][237][238]. Interestingly, Sin Hang Lee has identified naked non-proliferating HPV-16 L1 gene DNA fragments in non-B-conformation, in the macrophages of postmortem blood and spleen, apparently protected from degradation by binding firmly to the particulate aluminum adjuvant used in vaccine formulation [146].…”

Section: Induction Of Oxidative Genotoxic and Protein Conformationamentioning

confidence: 99%

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Davidson¹,

Lauritzen

Seneff

2013

Entropy

View full text Add to dashboard Cite

This paper postulates that water structure is altered by biomolecules as well as by disease-enabling entities such as certain solvated ions, and in turn water dynamics and structure affect the function of biomolecular interactions. Although the structural and dynamical alterations are subtle, they perturb a well-balanced system sufficiently to facilitate disease. We propose that the disruption of water dynamics between and within cells underlies many disease conditions. We survey recent advances in magnetobiology, nanobiology, and colloid and interface science that point compellingly to the crucial role played by the unique physical properties of quantum coherent nanomolecular clusters of magnetized water in enabling life at the cellular level by solving the "problems" of thermal diffusion, intracellular crowding, and molecular self-assembly. Interphase water and cellular surface tension, normally maintained by biological sulfates at membrane surfaces, are compromised by exogenous interfacial water stressors such as cationic aluminum, with consequences that include greater local water hydrophobicity, increased water tension, and interphase stretching. The ultimate result is greater "stiffness" in the extracellular matrix and either the "soft" cancerous state or the "soft" neurodegenerative state within cells. Our hypothesis provides a basis for understanding why so many idiopathic diseases of today are highly stereotyped and pluricausal. OPEN ACCESSEntropy 2013, 15 3823

show abstract

“…There have been several reports of post-licensure adverse events, some of which have even been fatal [125]. Compared to other vaccines, an unusually high proportion of adverse drug reactions has been reported associated with HPV vaccines [126].…”

Section: Human Papilloma Virus (Hpv) Vaccinementioning

confidence: 99%

Vaccines, adjuvants and autoimmunity

Guimarães

Baker

Perricone

et al. 2015

Pharmacological Research

200

144

View full text Add to dashboard Cite

Vaccines and autoimmunity are linked fields. Vaccine efficacy is based on whether host immune response against an antigen can elicit a memory T-cell response over time. Although the described side effects thus far have been mostly transient and acute, vaccines are able to elicit the immune system towards an autoimmune reaction. The diagnosis of a definite autoimmune disease and the occurrence of fatal outcome post-vaccination have been less frequently reported. Since vaccines are given to previously healthy hosts, who may have never developed the disease had they not been immunized, adverse events should be carefully accessed and evaluated even if they represent a limited number of occurrences. In this review of the literature, there is evidence of vaccine-induced autoimmunity and adjuvant-induced autoimmunity in both experimental models as well as human patients. Adjuvants and infectious agents may exert their immune-enhancing effects through various functional activities, encompassed by the adjuvant effect. These mechanisms are shared by different conditions triggered by adjuvants leading to the autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). In conclusion, there are several case reports of autoimmune diseases following vaccines, however, due to the limited number of cases, the different classifications of symptoms and the long latency period of the diseases, every attempt for an epidemiological study has so far failed to deliver a connection. Despite this, efforts to unveil the connection between the triggering of the immune system by adjuvants and the development of autoimmune conditions should be undertaken. Vaccinomics is a field that may bring to light novel customized, personalized treatment approaches in the future.

show abstract

Detection of human papillomavirus L1 gene DNA fragments in postmortem blood and spleen after Gardasil<sup>®</sup> vaccination—A case report

Cited by 20 publications

References 51 publications

Human Papilloma Virus Vaccine and Primary Ovarian Failure: Another Facet of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants

Human Papilloma Virus Vaccine and Primary Ovarian Failure: Another Facet of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Vaccines, adjuvants and autoimmunity

Contact Info

Product

Resources

About