Detection of Human Papillomavirus DNA in Patients with Breast Tumor in China

Li, Jie; Ding, Jie; Zhai, Kan

doi:10.1371/journal.pone.0136050

Cited by 38 publications

(39 citation statements)

References 54 publications

(44 reference statements)

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“…These results indicate that despite the controversial DNA detection of human papillomavirus (54,55), it was not a problem for EBV DNA detection (13,17). The subgroup analysis by types of control tissue also showed the same findings.…”

Section: Discussionsupporting

confidence: 64%

Epstein-Barr Virus Infection and Risk of Breast Cancer: An Adaptive Meta-Analysis for Case-Control Studies

Bae

Kim

2016

Arch Clin Infect Dis

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Context: The association between 'Epstein-Barr' virus (EBV) and breast cancer risk still remains controversial. A Systemic Review (SR) published in 2012 reported that there might be a statistically significant association between EBV and risk of breast cancer. However, errors were found in the appraisal process of the concerned SR. Objectives:The aim of this report was to conduct an adaptive meta-analysis with additional extraction of relevant papers published up until September 2015.Data Sources: The lists of references, cited articles and related articles provided by PubMed were made using the articles selected in the previous SR.Study Selection: Among these articles, only case-control studies using Polymerase Chain Reaction (PCR) techniques to detect EBV DNA in tissues were selected. Data Extraction: The summary odds ratio (SOR) and the 95% confidence interval (CI) were calculated though meta-analysis.Results: A total of 20 case-control studies were selected, and the total numbers of subjects in the case and control groups were 1947 and 1010, respectively. The findings of this meta-analysis revealed that EBV infection might increase the risk of breast cancer (SOR = 3.84, 95% CI: 2.24-6.58; I-squared = 62.2%). Sub-group analyses by region, sample type, and control tissue showed that a statistical significance of the risk was still secured. Conclusions:The findings of the meta-epidemiological study support that EBV infection may increase the risk of breast cancer. Nested case-control studies are required in the future.

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Section: Discussionsupporting

confidence: 64%

Epstein-Barr Virus Infection and Risk of Breast Cancer: An Adaptive Meta-Analysis for Case-Control Studies

Bae

Kim

2016

Arch Clin Infect Dis

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“…We found 43 molecular studies evaluating the detection of HPV in mammary carcinoma tissues, some of which compared cases to nonneoplastic controls [39-81]. Table 2 lists these articles, in chronological order of publication, summarizing the main types of samples, the preservation of samples, methods of detection, types of tissue, and the proportion of positive samples for the markers studied.…”

Section: Resultsmentioning

confidence: 99%

“…Most studies employed an initial PCR amplification using the standard commercially available primers used to screen HPV in cervical tissue [41, 42, 44, 47, 50-52, 54, 55, 57-61, 63, 65, 66, 69, 73, 76, 77, 80, 81]. These primer sets, like GP, MY, SPF, are within the L1 region, which codes most of the proteins in the viral capsid, and they more accurately detect the best known genital and/or oncogenic HPV types, i.e., HPV 6, 11 , 16, 18, 31, 33, 35, 39, 40, 42, 45, and 51–59.…”

Section: Resultsmentioning

confidence: 99%

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Is Human Papilloma Virus Associated with Breast Cancer? A Review of the Molecular Evidence

2018

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Background: Although the association of human papillomavirus (HPV) with many cancers is well established, the involvement of HPV in breast cancer remains controversial. The purpose of this study is to perform a comprehensive review of the results and methods used to demonstrate that HPV markers are present in human breast cancer, and how well these studies fulfil the criteria for proving the viral etiology of a cancer. Study Design: We conducted a search for molecular studies published until November 2016 that relate human breast cancer to HPV. Results: Forty-three original molecular studies were found, some of which compared cases to nonneoplastic controls. Some investigations did not identify HPV in mammary tissue, but others identified it with different frequencies of positivity, varying between 1.2 and 86%. In most case-control studies (21/24 studies), positivity in cases was found to be higher than in controls, but odds ratios and confidence intervals were not reported. Conclusion: The results are controversial. However, they arouse a great interest in the potential participation of HPV in breast carcinogenesis, but rather as an essential cause-effect participant, at least as a co-participant in some cases. The circumstance of HPV positivity in breast cancer can be criticized, but the elements that clearly demonstrate it in a number of cases are also relevant.

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“…The forest plot for relationship between breast cancer and human papillomavirus infection in case-control setting [5,7-9,11-19,23-26,28,33-36]. OR, odds ratio; CI, confidence interval.…”

Section: Figmentioning

confidence: 99%

Detection of Human Papillomavirus in Korean Breast Cancer Patients by Real-Time Polymerase Chain Reaction and Meta-Analysis of Human Papillomavirus and Breast Cancer

Choi¹,

Kim²,

Lee³

et al. 2016

J Pathol Transl Med

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BackgroundHuman papillomavirus (HPV) is a well-established oncogenic virus of cervical, anogenital, and oropharyngeal cancer. Various subtypes of HPV have been detected in 0% to 60% of breast cancers. The roles of HPV in the carcinogenesis of breast cancer remain controversial. This study was performed to determine the prevalence of HPV-positive breast cancer in Korean patients and to evaluate the possibility of carcinogenic effect of HPV on breast.MethodsMeta-analysis was performed in 22 case-control studies for HPV infection in breast cancer. A total of 123 breast cancers, nine intraductal papillomas and 13 nipple tissues of patients with proven cervical HPV infection were tested by real-time polymerase chain reaction to detect 28 subtypes of HPV. Breast cancers were composed of 106 formalin-fixed and paraffin embedded (FFPE) breast cancer samples and 17 touch imprint cytology samples of breast cancers.ResultsThe overall odds ratio between breast cancer and HPV infection was 5.43 (95% confidence interval, 3.24 to 9.12) with I² = 34.5% in meta-analysis of published studies with case-control setting and it was statistically significant. HPV was detected in 22 cases of breast cancers (17.9%) and two cases of intaductal papillomas (22.2%). However, these cases had weak positivity.ConclusionsThese results failed to serve as significant evidence to support the relationship between HPV and breast cancer. Further study with larger epidemiologic population is merited to determine the relationship between HPV and breast cancer.

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Detection of Human Papillomavirus DNA in Patients with Breast Tumor in China

Cited by 38 publications

References 54 publications

Epstein-Barr Virus Infection and Risk of Breast Cancer: An Adaptive Meta-Analysis for Case-Control Studies

Epstein-Barr Virus Infection and Risk of Breast Cancer: An Adaptive Meta-Analysis for Case-Control Studies

Is Human Papilloma Virus Associated with Breast Cancer? A Review of the Molecular Evidence

Detection of Human Papillomavirus in Korean Breast Cancer Patients by Real-Time Polymerase Chain Reaction and Meta-Analysis of Human Papillomavirus and Breast Cancer

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