Detection of Human Herpesvirus 7 in Patients with Pityriasis rosea and Healthy Individuals  /  Reply

Yoshida, Minoru; Drago, Francesca; Ranieri, E.; Rebora, Alfredo

doi:10.1159/000018246

Cited by 21 publications

(21 citation statements)

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“…However, these positive results were not confirmed by most other investigators [43][44][45][46][47][48][49][50][51]. Kempf et al [43] detected HHV-7 DNA and expression of HHV-7-specific immunodominant pp85 antigen in only 1 (8 %) out of 13 lesional biopsy specimens of PR and in 2 (14 %) out of 14 biopsy specimens of control subjects.…”

Section: Evidence For Specific Infectious Aetiologymentioning

confidence: 87%

“…Kempf et al [43] detected HHV-7 DNA and expression of HHV-7-specific immunodominant pp85 antigen in only 1 (8 %) out of 13 lesional biopsy specimens of PR and in 2 (14 %) out of 14 biopsy specimens of control subjects. Yoshida [44] detected approximately equal HHV-7 DNA signal intensity in whole-blood samples of four patients with PR and three healthy controls. Yasukawa et al [45] detected HHV-7 DNA in 1 (7 %) out of 14 patients with PR and none out of 15 controls.…”

Section: Evidence For Specific Infectious Aetiologymentioning

confidence: 95%

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Pityriasis rosea evidence for and against an infectious aetiology

Chuh

Chan

Zawar³

2004

Epidemiol. Infect.

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Pityriasis rosea, first named as such in 1860, probably holds the longest record for an exanthem suspected to be associated with an infection but for which an exact cause has not been found. The distinctly programmed clinical course, the lack of recurrence for most patients, and the presence of temporal case clustering provide the strongest evidence to support an infectious aetiology. Further support comes from seasonal variation and the association with respiratory tract infections, the unfavourable social and economic background of cases, and a history in some cases of contact with patients with pityriasis rosea. The apparent therapeutic efficacy of several treatment modalities does not provide strong evidence for or against an infectious aetiology. The roles of human herpesvirus 7 and to a lesser extent human herpesvirus 6 remain controversial. There exists reasonable evidence that pityriasis rosea is not associated with cytomegalovirus, Epstein-Barr virus, parvovirus B19, picornavirus, influenza and parainfluenza viruses, Legionella spp., Mycoplasma spp. and Chlamydia spp. infections. Evidence is also unsubstantiated as yet for alternative aetiological hypotheses such as autoimmunity, atopy, and genetic predisposition.

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Section: Evidence For Specific Infectious Aetiologymentioning

confidence: 87%

Section: Evidence For Specific Infectious Aetiologymentioning

confidence: 95%

Pityriasis rosea evidence for and against an infectious aetiology

Chuh

Chan

Zawar³

2004

Epidemiol. Infect.

View full text Add to dashboard Cite

show abstract

“…One study 5 was a seroepidemiological study aimed at detecting human herpesvirus 6 and 7 infections by serologic analysis and by polymerase chain reaction analysis. Another 31 was a cross-sectional study based on 1-day surveys.…”

Section: Resultsmentioning

confidence: 99%

Temporal Case Clustering in Pityriasis Rosea

Chuh

Molinari²,

Sciallis³

et al. 2005

Arch Dermatol

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“…Yoshida et al 24 reported that HHV-7 DNA signal intensity was almost equal in the blood specimens of the 4 PR-diagnosed patients and 3 healthy control subjects. Offidani et al 18 studied HHV-7 DNA in urine, saliva, PBMC, scales of 12 PR-diagnosed patients and 20 control subjects.…”

Section: Discussionmentioning

confidence: 99%

“…[15][16][17][18][19]23,24 Kosuge et al 23 have performed PCR and indirect immunofluorescence tests for HHV-6 and HHV-7 in 44 PR-diagnosed patients and 25 patients with other skin disorders and they concluded that HHV-6 and HHV-7 may play a role in some PRdiagnosed patients, but other causative agents may exist.…”

Section: Discussionmentioning

confidence: 99%