Detection of histone deacetylase inhibition by noninvasive magnetic resonance spectroscopy

Sankaranarayanapillai, Madhuri; Tong, William P.; Maxwell, David S.; Pal, Ashutosh; Pang, Jihai; Bornmann, William G.; Gelovani, Juri G.; Ronen, Sabrina M.

doi:10.1158/1535-7163.mct-05-0494

Cited by 32 publications

(36 citation statements)

References 53 publications

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“…Significant increases in PC were seen in HT29 cells after LAQ824 ( Figure 1A) and SAHA treatment . A rise in PC was also observed in PC3 prostate cancer cells after treatment with an analogue of SAHA (Sankaranarayanapillai et al, 2006).…”

Section: Mrs-detectable Pd Biomarkers Of Targeted Cancer Therapiesmentioning

confidence: 78%

Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy

et al. 2009

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Developing rational targeted cancer drugs requires the implementation of pharmacodynamic (PD), preferably non-invasive, biomarkers to aid response assessment and patient follow-up. Magnetic resonance spectroscopy (MRS) allows the non-invasive study of tumour metabolism. We describe the MRS-detectable PD biomarkers resulting from the action of targeted therapeutics, and discuss their biological significance and future translation into clinical use.

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Section: Mrs-detectable Pd Biomarkers Of Targeted Cancer Therapiesmentioning

confidence: 78%

Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy

et al. 2009

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“…In most cases, a therapeutic effect is associated with a decrease in tCho or PCho. However, the opposite effect is seen with histone deacetylase inhibitors, which repeatedly have been shown to increase tCho concentrations in vivo and ex vivo [141,142]. GPC concentrations may both increase and decrease following drug treatment, complicating the overall picture.…”

Section: Phospholipid Metabolism In Evaluation Of Response To Therapymentioning

confidence: 99%

HR MAS MR Spectroscopy in Metabolic Characterization of Cancer

Moestue¹,

Sitter²,

Bathen³

et al. 2011

CTMC

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One of the central hallmarks of cancer is the rapid and infinite cellular proliferation. In order to cope with increased requirement for building blocks and energy, cancer cells develop abnormal metabolic properties. Detailed assessment of cancer cell metabolism can provide biological information for use in both drug discovery and development of personalized cancer therapy. Analysis of intact tissue using high resolution magic angle spinning (HR MAS) magnetic resonance spectroscopy (MRS) gives qualitative and quantitative metabolite measures with minimal sample preparation. Multivariate statistical methods are important tools for analysis of complex MR data and have in recent years been used for analysis of HR MAS data from intact tissue. HR MAS analysis of intact tissue allows combination of metabolomic data with genomic or proteomic data, and can therefore be used both for exploring the molecular biology of cancer and for clinical improvements in cancer diagnostics, prognostics and treatment planning. In this review, the basic concepts of HR MAS are presented, and its use in characterisation of cancer metabolism is discussed with specific focus on selected pathways such as choline metabolism and glycolysis. The use of HR MAS in analysis of amino acids and lipid metabolism in cancer is also reviewed. Finally, the expected role of HR-MAS in metabolic characterisation in the near future is discussed.

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“…Increased PC and total choline levels were found in SAHA-treated cell extracts, and these changes were inversely correlated with resulting growth inhibition, cell-cycle arrest and apoptosis, and HDAC activity. 96 P-NMR spectra of LAQ824-treated tumor extracts when compared with controls. An increase in PC was also found in LAQ-treated HT29 cell extracts.…”

Section: Hdac Inhibitorsmentioning

confidence: 99%