Detection of hepatitis b virus DNA in the blood of a stem cell donor after granulocyte colony‐stimulating factor treatment

Punzel, Michael; Medd, Patrick; Hunter, Hannah; Cunningham, Richard; Pottinger, Bryson; Burde, Bernd; Widera, Marek; Quade, Annegret; Ehninger, Gerhard; Kozlova, A. A; Schmidt, Helmuth; Buhrmann, Karin; Schüttler, Christian G.; Glebe, Dieter; Billen, Annelies; Schmidt, Alexander H.; Mengling, Thilo; Verheyen, Jens

doi:10.1002/hep.28667

Cited by 2 publications

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“…HBV reactivation has been defined as the reappearance or rise of HBV DNA in patients with inactive or resolved HBV infection. Although it can occur spontaneously, it is mostly triggered by immunosuppression, often due to chemotherapy (for example treatment with rituximab), allogeneic hematopoietic stem cell transplantation (aHSCT) or solid organ transplantation [2,3].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Virological Aspects of HBV Reactivation: A Focus on Acute Liver Failure

Anastasiou

Theissen

Verheyen

et al. 2019

Viruses

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Hepatitis B virus (HBV) reactivation in immunosuppressed patients can cause considerable morbidity and mortality. The aim of our study was to evaluate factors associated with acute liver failure (ALF) in HBV reactivation. Clinical, laboratory, and virological data of 87 patients with HBV reactivation were analyzed retrospectively. Teno torque virus (TTV) plasma loads were measured as a measure of immune competence. HBV genomes isolated from 47 patients were analyzed by next-generation sequencing. A functional analysis of identified HBsAg mutants was performed. In patients with ALF the diagnosis was significantly later confirmed than in the non-ALF group. Patients diagnosed during immunosuppression had a milder clinical course compared to later diagnosed patients (p = 0.018, OR = 4.17). TTV viral loads did not differ significantly between the two groups. The HBV genomes isolated from ALF patients had higher viral complexity. A mutation in C-region of HBsAg (L216*), was associated with reduced HBsAg production and secretion. Patients diagnosed with HBV reactivation during immunosuppression had a milder clinical course compared to patients diagnosed during immune reconstitution. ALF was associated with higher viral complexity. An HBsAg mutation (L216*) was found to be more frequent in ALF patients and was associated with reduced HBsAg production and secretion.

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Section: Introductionmentioning

confidence: 99%