Detection of Helicobacter pylori in gastric cancer

Lp, Pereira; Waisberg, Jaques; Ea, André; Zanoto, Arnaldo; Júnior, Mendes; Hp, Soares

doi:10.1590/s0004-28032001000400006

Cited by 13 publications

(10 citation statements)

References 26 publications

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“…In the diffuse-type carcinoma the H. pylori was predominantly negative when the Giemsa and urease test were used. Our results are in contradiction to the works published by other authors (6,35) . H. pylori infection was found in 63.6% of patients with intestinal type early gastric cancer and in 54.5% of patients with diffuse-type early gastric cancer (9) .…”

Section: Discussioncontrasting

confidence: 99%

Prevalence of Helicobacter pylori infection in advanced gastric carcinoma

Araújo‐Filho

Brandão-Neto

Pinheiro

et al. 2006

Arq. Gastroenterol.

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Section: Discussioncontrasting

confidence: 99%

Prevalence of Helicobacter pylori infection in advanced gastric carcinoma

Araújo‐Filho

Brandão-Neto

Pinheiro

et al. 2006

Arq. Gastroenterol.

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“…This finding might be explained by the etiopathogenesis of gastric adenocarcinoma of the intestinal type, which is characterized by atrophic gastritis and intestinal metaplasia and involves factors such as dietary habits, exposure to H. pylori and smoking that share the preference for distal portions of the stomach (5,13,14,19,36) . Other studies have demonstrated the participation of these factors in the etiopathogenesis of gastric adenocarcinoma in the State of Pará (9,25,27,28,37) . Macroscopic analysis showed that most cases were advanced tumors, with the observation of a larger number of ulcerated-infiltrative lesions (Borrmann III), followed by ulcerated and delimited lesions (Borrmann II).…”

Section: Discussionmentioning

confidence: 96%

“…In addition, studies have shown a high prevalence of infection with Helicobacter pylori among patients with gastric adenocarcinoma from the State of Pará (25,37) . Taken together, these factors may explain the high incidence of gastric cancer in this region.…”

Section: Case Study Of Stomach Adenocarcinoma Conducted At a Cancer Rmentioning

confidence: 99%

Case study of stomach adenocarcinoma conducted at a cancer referral hospital in northern Brazil

Vinagre

Campos

Sousa

2012

Arq. Gastroenterol.

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-Context -Stomach cancer is the second leading cause of death due to cancer in the world and the incidence of this disease continues to be high in Brazil. In the Northern region, gastric cancer is the second most frequent cancer among men and the third among women. In the State of Pará, stomach adenocarcinoma is a public health problem since mortality rates are above the Brazilian average. Objective -To analyze the clinical and anatomopathological profile of stomach adenocarcinoma in patients seen at Ofir Loiola Hospital. Methods -In a retrospective study, records from 302 patients with gastric cancer undergoing surgery between 2006 and 2008 were analyzed. Data regarding patient profile, early symptoms, alterations upon physical examination, type of surgery, and macroscopic and histological findings were obtained from the records. Results -Most patients (63.9%) were men, 48% were older than 60 years, 50.9% were from the metropolitan region of Belém, 68.2% presented epigastric pain as an early symptom, and abdominal tenderness upon palpation was observed in 63.7%. The antrum was the most affected anatomical site (62.1%), followed by the gastric body (26.9%). Borrmann III (ulcerated-infiltrative) was the predominant endoscopic type. Adenocarcinoma accounted for 95.4% of all cases, including the intestinal type in 56.6% and the diffuse type in 41.3%. Most patients had stage IIIB and IV tumors and total gastrectomy was the most frequent type of surgery (37.4%). Conclusion -The present study demonstrated that gastric adenocarcinoma mainly affected men over the age of 60 who were from the metropolitan region of Belém. Most adenocarcinomas were in an advanced stage at the time of diagnosis, a fact requiring more aggressive surgical resection in these cases. These data highlight the urgent need for the implementation of preventive measures and early detection programs of gastric cancer. HEADINGS -Stomach neoplasms. Adenocarcinoma.

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“…In this study, we used the modified Gram staining method because it is widely utilised (Araujo et al 1993, Pereira et al 2001, Assumpção et al 2010 for the detection of bacteria in humans and has also been employed in studies with monkeys (Mackie & O'Rourke 2003).…”

Section: Discussionmentioning

confidence: 99%