Detection of Healed Myocardial Infarction With Multidetector-Row Computed Tomography and Comparison With Cardiac Magnetic Resonance Delayed Hyperenhancement

Sanz, Javier; Weeks, David M.; Nikolaou, Konstantin; Sirol, Marc; Rius, Teresa; Rajagopalan, Sanjay; Dellegrottaglie, Santo; Strobeck, John E.; Fuster, Valentín; Poon, Michael

doi:10.1016/j.amjcard.2006.01.093

Cited by 39 publications

(10 citation statements)

References 27 publications

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“…With this approach MI size is typically underestimated when compared with MR imaging [6,22]. It has been hypothesized that, during infarct healing, capillary infiltration from the periphery may not reach the infarct core, resulting in an underestimation of the MI size [23]. In accordance with the results known from the literature, the size of infarction was underestimated from arterial phase MDCT imaging in this study, too.…”

Section: Discussionsupporting

confidence: 78%

Multidetector computed tomography (MDCT) evaluation of myocardial viability: intraindividual comparison of monomeric vs. dimeric contrast media in a rabbit model

et al. 2008

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To evaluate the influence of different types of iodinated contrast media on the assessment of myocardial viability, acute myocardial infarction (MI) was surgically induced in six rabbits. Over a period of 45 min, contrast-enhanced cardiac MDCT (64 x 0.6 mm, 80 kV, 680 mAs(eff.)) was repeatedly performed using a contrast medium dose of 600 mg iodine/kg body weight. Animals received randomized iopromide 300 and iodixanol 320, respectively. Attenuation values of healthy and infarcted myocardium were measured. The size of MI was computed and compared with nitroblue tetrazolium (NBT)-stained specimen. The highest attenuation differences between infarcted and healthy myocardium occurred during the arterial phase with 140.0+/-3.5 HU and 141.0+/-2.2 HU for iopromide and iodixanol, respectively. For iodixanol the highest attenuation difference on delayed contrast-enhanced images was achieved 3 min post injection (73.5 HU). A slightly higher attenuation difference was observed for iopromide 6 min after contrast medium injection (82.2 HU), although not statistically significant (p=0.6437). Mean infarct volume as measured by NBT staining was 33.5%+/-13.6%. There was an excellent agreement of infarct sizes among NBT-, iopromide- and iodixanol-enhanced MDCT with concordance-correlation coefficients ranging from rho(c)=0.9928-0.9982. Iopromide and iodixanol both allow a reliable assessment of MI with delayed contrast-enhanced MDCT.

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Section: Discussionsupporting

confidence: 78%

Multidetector computed tomography (MDCT) evaluation of myocardial viability: intraindividual comparison of monomeric vs. dimeric contrast media in a rabbit model

et al. 2008

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“…For arterial as well as late-phase CT, the reported results correlate well with previous studies. After reperfusion, hypodense areas on arterial phase CT are known to typically underestimate the size of MI, when compared with histochemical analysis or delayed contrast enhancement (6,19,20). In this study, there was a substantial agreement between perfusion deficits on arterial phase CT and CMR as well as with TTC staining; nevertheless, arterial phase CT significantly underestimated the size of MI.…”

Section: Discussioncontrasting

confidence: 42%

“…Hypodense areas on arterial phase CT are thought to correspond to perfusion deficits; consequently, they consist of viable and nonviable myocardium. It has been hypothesized that during infarct healing, capillary infiltration from the periphery may not reach the infarct core, resulting in an underestimation of the MI size (20). The excellent agreement between areas of delayed contrast enhancement on late-phase CT and delayed enhanced CMR is in agreement with various studies, indicating the robustness of CT for viability imaging in acute MI (5,6,17,18,21).…”

Section: Discussionmentioning

confidence: 51%

Assessment of Myocardial Edema by Computed Tomography in Myocardial Infarction

Mahnken¹,

Bruners²,

Bornikoel³

et al. 2009

JACC: Cardiovascular Imaging

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“…In 42 patients, Sanz et al (15) reported that the sensitivity and specificity of postcontrast CT for the detection of MI (compared with MRI) were 91% and 81%, respectively. There was strong correlation between MI volume by CT as compared with MRI (r ϭ 0.87); however, CT substantially underestimated the volume of infarcted myocardium (2.7 Ϯ 2.5 ml vs. 25.9 Ϯ 19.9 ml).…”

Section: Viabilitymentioning

confidence: 97%

The Year in Cardiac Imaging

Gibbons

Araoz

Williamson

2007

Journal of the American College of Cardiology

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This review is a sequel to our previous reports highlighting the most important recent literature in single-photon emission computed tomography (SPECT) myocardial perfusion imaging, cardiac positron emission tomography (PET), cardiac computed tomography (CT), and cardiac magnetic resonance imaging (MRI). In almost all cases, these studies were published in the English-language literature between April 1, 2006, and March 31, 2007. The decision to arbitrarily include some articles and exclude others is more difficult each year. Time has exposed some of our previous errors. Last year, we did not include the first case report on nephrogenic systemic fibrosis. This year, we added a whole new safety section on this topic. We can assure both authors and readers that we have done our best to put aside personal biases in reaching these difficult decisions. We have again organized this summary around topical themes in an effort to encourage a broad, multimodality approach to the application of imaging to clinical problems. Technical AdvancesPET. Although cardiac F-18 fluorodeoxyglucose (FDG)-PET imaging is a well-established technique, vascular FDG-PET imaging is not. Two studies addressed this emerging area. Tawakol et al. (1) compared the results of FDG-PET imaging with tissue samples obtained during subsequent carotid endarterectomy to demonstrate a significant correlation between FDG uptake and both carotid plaque and macrophage staining. This early study offers great promise if subsequent studies demonstrate that increased carotid FDG activity predicts subsequent cerebrovascular events. Tahara et al. (2) used FDG-PET vascular imaging in a randomized trial of 43 patients to demonstrate a decrease in FDG uptake in patients treated with simvastatin. CT. The rapid technical advances in CT continue. Early studies described the use of 256-row cone beam and dual-source CT, both introduced in last year's review. Using dual-source CT, Johnson et al. (3) demonstrated impressive temporal resolution and robust coronary artery imaging at a wide range of heart rates. Scheffel et al. ( 4) showed similar results, with excellent negative predictive value for Ͼ50% stenosis despite a lack of beta-blockade. MRI. Advances in MRI software and computer processing have lead to faster, more robust performance. There is a small-but-growing literature in which MRI acquisitions are acquired in a single breath hold, or in a free-breathing state. Attempts to decrease the breathing requirements for MRI volume measurements are summarized in Table 1 (5-10). The ability to perform MRI acquisitions in a single breath hold, or in a free-breathing state, would substantially reduce the main limitation of MRI (i.e., the level of required patient cooperation). Viability PET.Previous studies have reported conflicting data on the duration of survival of hibernating myocardium. Wiggers et al. (11) performed serial sestamibi SPECT and FDG-PET on 16 patients with chronically stunned or hibernating myocardium who were treated with medical therapy for approximatel...

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Detection of Healed Myocardial Infarction With Multidetector-Row Computed Tomography and Comparison With Cardiac Magnetic Resonance Delayed Hyperenhancement

Cited by 39 publications

References 27 publications

Multidetector computed tomography (MDCT) evaluation of myocardial viability: intraindividual comparison of monomeric vs. dimeric contrast media in a rabbit model

Multidetector computed tomography (MDCT) evaluation of myocardial viability: intraindividual comparison of monomeric vs. dimeric contrast media in a rabbit model

Assessment of Myocardial Edema by Computed Tomography in Myocardial Infarction

The Year in Cardiac Imaging

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