Detection of Gene--Environment Interaction by Case-only Studies

Hamajima, Nobuyuki; Yuasa, Hidemichi; Matsuo, Keitaro; Kurobe, Yohko

doi:10.1093/jjco/29.10.490

Cited by 29 publications

(19 citation statements)

References 8 publications

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“…It will be recognized as McNamara's test for a pairmatched case-control study. The "case" is the transmitted allele and the "control" is the nontransmitted allele [35].…”

Section: Odds Ratio In Matchedmentioning

confidence: 99%

“…One of the most functional studies in genetic epidemiology is the case-only which is used for cross-sectional, cohort, or case control patients [35]. The case-only design which is to assess geneenvironment interaction was presented by Aalen et al and then by Hamajima et al [35].…”

Section: Estimation Of Interaction In Exposuresmentioning

confidence: 99%

“…The case-only design which is to assess geneenvironment interaction was presented by Aalen et al and then by Hamajima et al [35]. The case-only study design used to study gene-environment interaction has been criticized for its susceptibility to bias caused by nonindependence between genetic and environmental factors [39][40][41].…”

Section: Estimation Of Interaction In Exposuresmentioning

confidence: 99%

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Study Designs in Genetic Epidemiology

et al. 2013

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Genetic epidemiology, as a relatively new issue, aims to explore the independent role of genetic-environmental determinants of diseases. Genetic epidemiology studies, depending on the objective, encompass the most preliminary surveys from the attempts to find family history in the occurrence of diseases to the most advanced surveys including specific strategies by clinical trials in the prevention of genetic diseases. Different objectives in genetic epidemiology studies require special methods and study designs. In this review, chief designs including familial aggregation, heritability, segregation, linkage, and association are evaluated; likewise, the purpose of diverse kinds of studies and analyses is briefly discussed. The utilization of study designs and related analyses according to the aims are the main issues and necessary in the accurate implementation of the study. Some methodological issues in relation to studies on tuberculosis are also reported. Attention to these issues might be useful in the implementation of these methods in the studies designed for the prevention and treatment of genetic disorders.

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“…It will be recognized as McNamara's test for a pairmatched case-control study. The "case" is the transmitted allele and the "control" is the nontransmitted allele [35].…”

Section: Odds Ratio In Matchedmentioning

confidence: 99%

Section: Estimation Of Interaction In Exposuresmentioning

confidence: 99%

Section: Estimation Of Interaction In Exposuresmentioning

confidence: 99%

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Study Designs in Genetic Epidemiology

et al. 2013

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“…Host factors have been discussed conceptually among the epidemiologists for decades, but now we can investigate host factors in a concrete form by genotyping techniques. Together with the shift from solely environmental factor evaluation to interactions with genetic traits, new methodology has been emerged 17,[20][21][22][23]). An incomplete-data case-control design under the assumption of the independent distributions of exposure and genotype seems a powerful epidemiologic tool.…”

Section: Discussionmentioning

confidence: 99%

Adjustment of Prognostic Effects in Prevalent Case-control Studies on Genotype.

Hamajima

Matsuo

Yuasa

2001

Journal of Epidemiology

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“…[1][2][3] In order to obtain a stable estimate of the strength of an association, a large sample size is required. In recent studies on gene-environment and/or gene-gene interactions, 4,5) hundreds of subjects needed to be genotyped. Accordingly, there is a demand for a quick genotyping technique at a low cost.…”

mentioning

confidence: 99%