Detection of gastroduodenal ulcers using Technetium-99m-labeled sucralfate

Puttemans, Nicole; Lambert, Michele P.; André, P; S, Jamsin; Balikdjian, Daniel; Lustman, F

doi:10.1007/978-94-011-3316-6_9

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…On the other hand, the obtained results showed that the method of endoscopy combined with histopathological and microbiological analysis of biopsies is – due to its sensitivity, specificity and safety – a method “of choice” in clinical evaluation of metaplastic and non-metaplastic changes within HGMUE [43, 44]. …”

Section: Discussionmentioning

confidence: 99%

Clinical evaluation of twenty cases of heterotopic gastric mucosa of upper esophagus during five-year observation, using gastroscopy in combination with histopathological and microbiological analysis of biopsies

Latos¹,

Sieroń–Stołtny²,

Kawczyk‐Krupka³

et al. 2013

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Aim of the studyHeterotopic gastric mucosa of the upper esophagus (HGMUE) may be connected with disorders of the upper gastrointestinal tract, exacerbated by Helicobacter pylori. Furthermore, HGMUE may be the origin of malignant progression to cervical esophageal carcinoma.Material and methodsIn this work, 20 patients with diagnosed heterotopic gastric mucosa of the upper esophagus (HGMUE) were subjected to 5-year follow-up to determine the extent and structure of histopathological changes within HGMUEs, as well as HGMUE dysplasia and metaplasia, and risk of their malignant transformation. As a diagnostic tool to describe localization, form, size and surface feature of HGMUEs, endoscopy was used. At the same time, the biopsies were collected for histopathological and microbiological analysis.ResultsIn examined patients, HGMUEs were associated with inflammation, chronic gastritis, hiatus hernia, duodenal bulb erosion and ulcer and infection of H. pylori. Intestinal metaplasia and low grade dysplasia were also indicated. During 5 years of observation, both the clinical and histopathological image of diagnosed HGMUEs was stable. The patients with detected presence of H. pylori were treated with triple or quadruple therapy.These results show that HGMUEs may be associated with severe complications in the gastrointestinal tract, such as infection by H. pylori, hiatus hernia or duodenal ulcer. Although dysplasias and metaplasias found in diagnosed HGMUEs were not very numerous and relatively stable both clinically and histopathologically, at the present stage of the study we cannot exclude the possibility of HGMUE malignant transformation.

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Section: Discussionmentioning

confidence: 99%