Detection of fluoroquinolone‐induced tendon disorders using a hospital database in Japan

Hori, Kazuyuki; Yamakawa, Kasumi; Yoshida, Naoko; Ohnishi, Kazunori; Kawakami, Junichi

doi:10.1002/pds.3285

Cited by 26 publications

(12 citation statements)

References 11 publications

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“…Tendonitis or rupture of the Achilles tendon has occurred in adults receiving azithromycin or sulfonamides, respectively [12,19]. Similar to the patient described in this report, tendonitis and tendon rupture have also been observed in other individuals who have received cephalosporins [12,19-20].…”

Section: Discussionsupporting

confidence: 65%

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Cephalexin-associated Achilles Tendonitis: Case Report and Review of Drug-induced Tendinopathy

Cohen¹

2018

Cureus

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Tendon disorders include tenosynovitis or tendonitis, tendinosis, and tendon rupture. Tendinopathy associated with drug administration has been associated with the systemic or local administration of several medications. A 90-year-old man who developed toxic tendinopathy after receiving cephalexin 500 mg twice daily has been described. Unilateral pain of his left Achilles tendon pain during walking appeared three weeks after starting the antibiotic. The drug was stopped after four weeks of treatment; within one week after discontinuing the cephalexin, all tendonitis symptoms spontaneously resolved. Drug-induced tendinopathy has most commonly been associated with fluoroquinolones, statins, glucocorticoids, and aromatase inhibitors. In addition, other systemic agents have caused tendinopathy; they include amlodipine, anabolic steroids, antiretrovirals, isotretinoin, renin-angiotensin II receptor antagonists, rituximab, and sitagliptin. Albeit less frequent, other oral antibiotics, including cephalosporins, azithromycin, and sulfonamides, have also been associated with toxic tendinopathy. Also, injections of collagenase Clostridium histolyticum, corticosteroids, and polidocanol have been followed by tendon rupture. The features of tendinopathy associated with drug treatment are summarized and their postulated mechanisms of pathogenesis are reviewed. The onset of tendon pain following the initiation of treatment with a new medication, especially if the agent has previously been associated with drug-induced tendonitis, tendinosis, or tendon rupture, should prompt the consideration of drug-associated toxic tendinopathy.

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Section: Discussionsupporting

confidence: 65%

“…Tendon disorders can range from tendonitis to rupture [1-3]. Several medications have been implicated in toxic tendinopathy associated with drug administration [1-20]. A man with cephalexin-associated tendonitis is described and agents that have been implicated in drug-induced tendinopathy are reviewed.…”

Section: Introductionmentioning

confidence: 99%

Cephalexin-associated Achilles Tendonitis: Case Report and Review of Drug-induced Tendinopathy

Cohen¹

2018

Cureus

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“…Likewise, half of tendon ruptures have been shown to occur within one week 7,8 . The incidence of tendon injury is between 0.08% and 0.20% 15,16 .…”

Section: Discussionmentioning

confidence: 99%

Ciprofloxacin-Induced Extensor Tendon Rupture in the Hand

DeWolf

Warhold

2015

JBJS Case Connector

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“…In 2008, the FDA issued a black‐box warning regarding use of quinolones and the associated risk of tendon, specifically Achilles tendon, injuries . Since the initial warning, the FDA has updated its advisory, and further studies have described risks associated with quinolone use . These supplement the studies already undertaken before the advisory was issued and perhaps prompted its release .…”

Section: Discussionmentioning

confidence: 99%

“…Quinolones, a popular class of antibiotics used for a variety of infections, were associated with Achilles tendon injuries in numerous epidemiologic studies . Although the exact mechanism is unknown, quinolones may cause direct injury to tendon cells, including necrosis and cellular apoptosis, and indirect injury through release of tissue‐damaging substance such as nitric oxide and oxygen‐derived species.…”

mentioning

confidence: 99%

The Relative Risk of Achilles Tendon Injury in Patients Taking Quinolones

et al. 2018

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Although quinolone use increases the risk of Achilles tendon injury, the absolute risk increase is minimal, especially when compared with similar morbidity patients taking other nonquinolone antibiotics. In relatively healthy populations, such as the one studied here, quinolone use may not make a clinically significant contribution to risk of Achilles tendon injury, at any age range, among those in need of such drugs.

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Detection of fluoroquinolone‐induced tendon disorders using a hospital database in Japan

Abstract: A hospital database search revealed that the risk of tendon disorders in Japanese patients administered with FQs was higher than in those administered with cephalosporins.

Cited by 26 publications

References 11 publications

Cephalexin-associated Achilles Tendonitis: Case Report and Review of Drug-induced Tendinopathy

Cephalexin-associated Achilles Tendonitis: Case Report and Review of Drug-induced Tendinopathy

Ciprofloxacin-Induced Extensor Tendon Rupture in the Hand

The Relative Risk of Achilles Tendon Injury in Patients Taking Quinolones

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