Detection of Fibroproliferation by Chest High-Resolution CT Scan in Resolving ARDS

Burnham, Ellen L.; Hyzy, Robert C.; Paine, Robert; Kelly, Aine Marie; Quint, Leslie E.; Lynch, David; Curran‐Everett, Douglas; Moss, Marc; Standiford, Theodore J.

doi:10.1378/chest.13-2708

Cited by 31 publications

(28 citation statements)

References 24 publications

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“…The imbalance between MMPs and TIMPs favors fibrosis, and this imbalance has been reported in the lungs of patients with ARDS and in animal models (11, 12, 33, 34). Compared with the control, lung of LPS‐treated mice showed increased collagen fiber content in the alveolar septa (P < 0.01; Fig.…”

Section: Resultsmentioning

confidence: 85%

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Acute lung injury is reduced by the α7nAChR agonist PNU‐282987 through changes in the macrophage profile

et al. 2016

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Nicotinic α-7 acetylcholine receptor (nAChRα7) is a critical regulator of cholinergic anti-inflammatory actions in several diseases, including acute respiratory distress syndrome (ARDS). Given the potential importance of α7nAChR as a therapeutic target, we evaluated whether PNU-282987, an α7nAChR agonist, is effective in protecting the lung against inflammation. We performed intratracheal instillation of LPS to generate acute lung injury (ALI) in C57BL/6 mice. PNU-282987 treatment, either before or after ALI induction, reduced neutrophil recruitment and IL-1β, TNF-α, IL-6, keratinocyte chemoattractant (KC), and IL-10 cytokine levels in the bronchoalveolar lavage fluid (P< 0.05). In addition, lung NF-κB phosphorylation decreased, along with collagen fiber deposition and the number of matrix metalloproteinase-9 and -2 cells, whereas the number of tissue inhibitor of metalloproteinase-1 cells increased (P < 0.05). PNU-282987 treatment also reduced lung mRNA levels and the frequency of M1 macrophages, whereas cells expressing the M2-related markers CD206 and IL-10 increased, suggesting changes in the macrophage profile. Finally, PNU-282987 improved lung function in LPS-treated animals. The collective results suggest that PNU-282987, an agonist of α7nAChR, reduces LPS-induced experimental ALI, thus supporting the notion that drugs that act on α7nAChRs should be explored for ARDS treatment in humans.-Pinheiro, N. M., Santana, F. P. R., Almeida, R. R., Guerreiro, M., Martins, M. A., Caperuto, L. C., Câmara, N. O. S., Wensing, L. A., Prado, V. F., Tibério, I. F. L. C., Prado, M. A. M., Prado, C. M. Acute lung injury is reduced by the α7nAChR agonist PNU-282987 through changes in the macrophage profile.

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Section: Resultsmentioning

confidence: 85%

“…Collagen deposition has been observed in the lungs of patients with ARDS and in animal models (11, 12, 33, 34, 52), and this change has been suggested to be caused by alterations in ECM components (11, 12). In animal models, it has been shown that 24 h after LPS instillation, the deposition of some ECM components is increased (52, 53).…”

Section: Discussionmentioning

confidence: 99%

Acute lung injury is reduced by the α7nAChR agonist PNU‐282987 through changes in the macrophage profile

et al. 2016

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“…The group with well-aerated lung region/pTLC ≥40 % showed better survival outcome. Some reports have noted that patients with large ill-aerated lung regions experience poorer prognosis than patients with small ill-aerated lung regions [4][5][6]16], but no reports have focused on the well-aerated lung region of patients with ARDS. This is the first report to describe the relationship between well-aerated lung region and prognosis in patients with ARDS.…”

Section: Discussionmentioning

confidence: 99%

A predictive factor for patients with acute respiratory distress syndrome: CT lung volumetry of the well-aerated region as an automated method

Nishiyama

Kawata

Yokota

et al. 2020

European Journal of Radiology

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“…2 Whereas a conventional chest x-ray is mandatory for the diagnosis of ARDS, computed tomography (CT) is not required to satisfy the diagnostic criteria outlined in the Berlin definition. However, CT scans in patients with ARDS are often performed for the following indications: confirmation of diagnosis, 3 assessment of recruitability, 4 identification of a pulmonary or extrapulmonary cause, 5 prediction of prognosis, [6][7][8] and follow-up. 9 Many ARDS centers, including our department, routinely perform CT scans in patients with ARDS, believing that this may yield clinically relevant information.…”

Section: Introductionmentioning

confidence: 99%

Value of Computed Tomography of the Chest in Subjects With ARDS: A Retrospective Observational Study

et al. 2015

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BACKGROUND: The value of computed tomography (CT) of the chest in the management of patients with ARDS is poorly defined. The aim of this study was to assess the clinical utility of thoracic CT scans in subjects with ARDS using the Berlin definition. METHODS: This was a retrospective, observational study in a university hospital ARDS center on all subjects with ARDS in whom a CT scan of the chest was performed immediately before or during an ICU stay between January 1, 2007 and June 30, 2013. RESULTS: During the study period, a total of 1,781 thoracic CT scans were performed, of which 204 cases met inclusion criteria. The most common pathologic findings of the lung parenchyma were consolidations (94.1% of cases) and ground glass opacities (85.3%). Furthermore, CT scans showed pleural effusions (80.4%), mediastinal lymphadenopathy (66.7%), signs of right ventricular strain and pulmonary hypertension (53.9%), pericardial effusion (37.3%), emphysema of the chest wall (12.3%), pneumothorax (11.8%), emphysema of the mediastinum (7.4%), and pulmonary embolism (2.5%). Results of CT scans led to changes in management in 26.5% of cases. Mortality was significantly increased in subjects with involvement of lung parenchyma of >80% (P ‫؍‬ .004). Intrahospital transport was associated with critical incidents in 8.3% of cases. CONCLUSIONS: Systematic evaluation of thoracic CT scans yielded information useful for making a diagnosis, predicting prognosis, and recognizing concomitant disorders requiring therapeutic interventions. Results obtained from CT scans led to changes in management in 26.5% of cases.

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Detection of Fibroproliferation by Chest High-Resolution CT Scan in Resolving ARDS

Cited by 31 publications

References 24 publications

Acute lung injury is reduced by the α7nAChR agonist PNU‐282987 through changes in the macrophage profile

Acute lung injury is reduced by the α7nAChR agonist PNU‐282987 through changes in the macrophage profile

A predictive factor for patients with acute respiratory distress syndrome: CT lung volumetry of the well-aerated region as an automated method

Value of Computed Tomography of the Chest in Subjects With ARDS: A Retrospective Observational Study

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