Detection of extravasation of antineoplastic drugs by microwave radiometry

Shaeffer, James; El‐Mahdi, Anas M.; Hamwey, Albert E.; Carr, K.L.

doi:10.1016/0304-3835(86)90149-7

Cited by 25 publications

(9 citation statements)

References 6 publications

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“…An experiment involving extravasation of doxorubicin in dogs showed that a temperature decrease of more than 1.0°C was likely to indicate infiltration (7). This finding is supported by evidence that skin temperature decreases less than 1.0°C during proper intravenous therapy.…”

Section: Casementioning

confidence: 90%

“…Although infiltrating drugs are thought to lower the temperature of the surrounding tissues and the skin surface, few studies have examined this phenomenon. An experiment in dogs showed that microwave radiometry could be used to observe the decline in skin temperature during extravasation of doxorubicin into subcutaneous tissues (7). In addition, we used infrared thermography in an experiment to examine a model of infiltration in healthy adults (8).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Low-temperature infiltration identified using infrared thermography in patients with subcutaneous edema revealed ultrasonographically: A case report

Oya

Takahashi

Tanabe

et al. 2016

DD&T

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Section: Casementioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Low-temperature infiltration identified using infrared thermography in patients with subcutaneous edema revealed ultrasonographically: A case report

Oya

Takahashi

Tanabe

et al. 2016

DD&T

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“…Monitoring drug delivery for cancer treatment [2], hyperthermia temperature control [3], and hypothermic neural rescue of infants suffering from hypoxia-ischemia [4] also utilize noninvasive near-field radiometric measurements. Additionally, near-field applicators are used in microwave hyperthermia treatment [5] and nonmedical applications such as food processing [6].…”

Section: Introductionmentioning

confidence: 99%

Sensing Depth of Microwave Radiation for Internal Body Temperature Measurement

Scheeler

Kuester

Popović

2014

IEEE Trans. Antennas Propagat.

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This paper investigates modeling of the interaction of human tissues with a probe antenna situated on the surface of the skin. The goal is to differentiate temperature changes at different depths under the skin for passive radiometric measurements of internal body temperature. An improved metric is defined in order to differentiate thermal power radiated from a specific part of the tissue relative to the total thermal power received by the probe antenna. The frequency range between 0.5 and 3 GHz is investigated due to the sensing depth that can be achieved for a given receiver sensitivity. The general approach is to validate full-wave finite element method (FEM) EM simulations with a spectral-domain analysis for layered lossy dielectrics with a dipole at the interface between two of the layers. This was successfully done for a dipole on a water half-space and a stack of three tissues (skin, fat, and muscle). A new type of multifrequency probe was designed for 1.4, 2.7, and 4.9 GHz operation, and the predicted impedance validated experimentally. To the authors' knowledge, this is the first time that the near-field received power of a dipole probe placed in contact with lossy layered media is examined as a function of frequency. This is shown to be significantly different than the plane wave case, and is necessary knowledge for the design of a portable radiometer for microwave internal body thermometry.Index Terms-Biological tissues, dipole antennas, electromagnetic propagation in absorbing media, microwave radiometry, multilayered media, spectral domain analysis.

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“…Additional applications, which have been investigated, comprise detection of inflammatory arthritis (MacDonald et al, 1994), extravasation rate of drugs (J. Schaeffer & Carr, 1986), changes of blood flow (Gabrielyan et al, 1992) or amount of lung water (Iskander et al, 1984) as well as post-mortem or cerebral temperature monitoring (Al-Alousi et al, 1994). Microwave radiometry in clinical medicine aims at deriving information on internal body temperature patterns by measurement of natural thermal black-body radiation from tissue in the lower part of the microwave region (<5 GHz).…”

Section: Introductionmentioning

confidence: 99%

Non-invasive temperature monitoring during microwave heating applying a miniaturized radiometer

Jacobsen¹

2011

Microwave Heating

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Detection of extravasation of antineoplastic drugs by microwave radiometry

Cited by 25 publications

References 6 publications

Low-temperature infiltration identified using infrared thermography in patients with subcutaneous edema revealed ultrasonographically: A case report

Low-temperature infiltration identified using infrared thermography in patients with subcutaneous edema revealed ultrasonographically: A case report

Sensing Depth of Microwave Radiation for Internal Body Temperature Measurement

Non-invasive temperature monitoring during microwave heating applying a miniaturized radiometer

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