Detection of Established and Novel Alleles of the HLA‐DPB1 Locus by PCR‐SSO

We studied MHC class-I and -II phenotypes in adult Caucasian patients with chronic idiopathic autoimmune thrombocytopenia (cAITP). Forty-five patients (median age 51 years, range 21-78 years) with a median disease duration of 7 years (range 2-26 years) were phenotyped for HLA-A, -B, -C by the standard lymphocytotoxicity test, HLA-DR and -DQ by restriction fragment-length polymorphism (RFLP), and -DP by oligonucleotide typing. Antiplatelet antibodies directed against glycoproteins Ib/IX and IIb/IIIa were determined by monoclonal antibody-specific immobilization of platelet antigens (MAIPA). The comparison of antigen frequencies of the whole group of patients with healthy controls revealed no significant difference for any of the MHC class-I or class-II specificities (p > 0.05). Patients were then divided into groups based on (a) their response to therapy, and (b) on whether they did or did not have detectable anti-platelet antibodies (n = 16 versus n = 29). All patients with a poor response to splenectomy carried the HLA-DPB1*0402 phenotype. The HLA-DPB1*1501 allele was found only among patients with detectable antiplatelet antibodies. These differences were not significant after correction for the number of tested antigens, however. Our data suggest that there is no association between MHC class-I/II alleles and adult cAITP or subgroups thereof.

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HLA class-I and -II antigens in chronic idiopathic autoimmune thrombocytopenia

Gaiger

Neumeister

Heinzl

et al. 1994

Ann Hematol

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Association between chronic cutaneous lupus erythematosus and HLA class II alleles

et al. 1994

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Balancing selection and heterogeneity across the classical human leukocyte antigen loci: A meta-analytic review of 497 population studies

Mack²,

et al. 2008

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This paper presents a meta-analysis of high-resolution human leukocyte antigen (HLA) allele frequency data describing 497 population samples. Most of the datasets were compiled from studies published in eight journals from 1990 to 2007; additional datasets came from the International Histocompatibility Workshops and from the AlleleFrequencies.net database. In all, these data represent approximately 66,800 individuals from throughout the world, providing an opportunity to observe trends that may not have been evident at the time the data were originally analyzed, especially with regard to the relative importance of balancing selection among the HLA loci. Population genetic measures of allele frequency distributions were summarized across populations by locus and geographic region. A role for balancing selection maintaining much of HLA variation was confirmed. Further, the breadth of this meta-analysis allowed the ranking of the HLA loci, with DQA1 and HLA-C showing strongest balancing selection and DPB1 being compatible with neutrality. Comparisons of the allelic spectra reported by studies since 1990 suggest that most of the HLA alleles identified since 2000 are very-low-frequency alleles. The literature-based allele-count data, as well as maps summarizing the geographic distributions for each allele, are available online.

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Detection of Established and Novel Alleles of the HLA‐DPB1 Locus by PCR‐SSO

Cited by 7 publications

References 20 publications

HLA class-I and -II antigens in chronic idiopathic autoimmune thrombocytopenia

HLA class-I and -II antigens in chronic idiopathic autoimmune thrombocytopenia

Association between chronic cutaneous lupus erythematosus and HLA class II alleles

Balancing selection and heterogeneity across the classical human leukocyte antigen loci: A meta-analytic review of 497 population studies

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