Detection of Epstein–Barr Virus in an Inflammatory Myofibroblastic Tumor of the Spleen (Inflammatory Pseudotumor)

Jiménez, Antonio Palomeque; Moreno, Montserrat Reyes; Baeza, Salvador Calzado; Jimena, Sergio Antonio Ranea; Soto, Paul Sebastian Robayo

doi:10.1016/j.cireng.2015.05.004

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…Inflammatory pseudotumor/IMT represent a heterogeneous group of solitary or multiple masses characterized histologically by fibroblastic or myofibroblastic proliferation (myofibroblastic spindle cells) with polymorphic, inflammatory infiltrates, and variable proportions of fibrosis, necrosis, and granulomatous reactions (29–32). Etiology and pathogenesis are unclear (4, 5, 30, 33).…”

Section: Discussionmentioning

confidence: 99%

“…Etiology and pathogenesis are unclear (4, 5, 30, 33). Inflammatory pseudotumor/IMT is known to appear in association with infections, autoimmune disorders, and posttraumatic disorders (29, 30, 32, 34–38).…”

Section: Discussionmentioning

confidence: 99%

“…It is unclear whether the decision in favor of a specific term is approved with regard to content or because it is customary. Some articles, including very recent ones, explicitly use the terms synonymously and interchangeably or do not differentiate between them (1, 7, 23, 32, 41–45).…”

Section: Discussionmentioning

confidence: 99%

“…Laboratory tests mainly reveal anemia; other findings indicating inflammatory processes can be thrombocytosis and elevated blood sedimentation rate and CRP (1, 28). Cytomegalovirus or EBV titers are positive in some cases (16, 32, 34).…”

Section: Discussionmentioning

confidence: 99%

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Inflammatory Pseudotumor (IPT) and Inflammatory Myofibroblastic Tumor (IMT): A Representative Literature Review Occasioned by a Rare IMT of the Transverse Colon in a 9-year-old Child

Höhne

Milzsch

Adams

et al. 2015

Tumori

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The liver and biliary tract were the most commonly affected of all body regions, at 32%. This was followed by the lung, including the respiratory tract, at 27%, and by the gastrointestinal tract, at 10%. Lesions of the large bowel, as in the present case of a 9-year-old boy, are very rare. There were organ-related as well as nonspecific clinical symptoms, such as fever, weight loss, and fatigue. Laboratory test results revealed anemia and elevated inflammation-dependent parameters. The patterns in medical imaging are variable and nonspecific. Morphology often suggests a malignant process. For this reason, therapy in most cases is surgical, but this is required more often in IMTs. Many IPTs could be treated conservatively.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Inflammatory Pseudotumor (IPT) and Inflammatory Myofibroblastic Tumor (IMT): A Representative Literature Review Occasioned by a Rare IMT of the Transverse Colon in a 9-year-old Child

Höhne

Milzsch

Adams

et al. 2015

Tumori

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Infantile Inflammatory Myofibroblastic Tumor of Spleen

Thirunavukkarasu

Roy

Gupta

et al. 2020

Fetal and Pediatric Pathology

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Granulomatous splenic mass with necrosis revealing an EBV-positive inflammatory follicular dendritic cell sarcoma

Ungureanu

Lupinacci

Parrens

et al. 2022

Journal of Surgical Case Reports

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Epstein–Barr virus-positive inflammatory follicular dendritic cell sarcoma is a variant of follicular dendritic cell neoplasm most often arising in the liver or spleen. Two histological patterns can be identified in this variant, namely a granulomatous and an eosinophil-rich one. We present the case of a 69-year-old woman with a splenic mass. After being removed, the mass was gray-whitish with an area of necrosis. Histology showed a diffuse distribution of epithelioid granulomas in a background of a dense lymphoplasmacytic infiltrate. Rare atypical cells EBV+ and CD21+ were present in the intergranulomatous areas. Differential diagnosis for the granulomatous type EBV+ inflammatory follicular dendritic cell sarcoma includes infection, sarcoidosis, inflammatory myofibroblastic tumor, T cell lymphoma and vasculitis. The origin of this neoplasm is the follicular dendritic cell, and, due to its similarities with a myofibroblast, differential diagnosis can be challenging. Immunohistochemistry for dendritic markers and in situ hybridization for EBER remain diagnostic keys.

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Detection of Epstein–Barr Virus in an Inflammatory Myofibroblastic Tumor of the Spleen (Inflammatory Pseudotumor)

Cited by 3 publications

References 9 publications

Inflammatory Pseudotumor (IPT) and Inflammatory Myofibroblastic Tumor (IMT): A Representative Literature Review Occasioned by a Rare IMT of the Transverse Colon in a 9-year-old Child

Inflammatory Pseudotumor (IPT) and Inflammatory Myofibroblastic Tumor (IMT): A Representative Literature Review Occasioned by a Rare IMT of the Transverse Colon in a 9-year-old Child

Infantile Inflammatory Myofibroblastic Tumor of Spleen

Granulomatous splenic mass with necrosis revealing an EBV-positive inflammatory follicular dendritic cell sarcoma

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