Detection of Epstein-Barr Viral RNA in Sinonasal Undifferentiated Carcinoma from Western and Asian Patients

Lopategui, Jean; Gaffey, M. J.; Frierson, Henry F.; Chan, John K. C.; Mills, Stacey E.; Chang, Karen L.; Chen, Yuanyuan; Weiss, Lawrence M.

doi:10.1097/00000478-199404000-00007

Cited by 74 publications

(25 citation statements)

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“…Indistinct cell borders with a syncytial growth pattern, limited mitotic activity, mild to moderate (less than in NPC) lymphoplasmacytic cell infiltrate, and usually absence of necrosis and keratinization are features identifiable in PSNPC which enables its differentiation from SNUC. Presence of EBV upon EBV-RNA in-situ hybridisation also differentiates PSNPC (3)(4)(5). Our case demonstrated histopathological, immunohistochemical and EBER-positive features consistent with those described by Jeng et al (2) and thus far has a similar survival outcome matched to the cases in their series, with similarstaged disease.…”

Section: Discussionsupporting

confidence: 90%

“…The description of a rare histological variant by Jeng et al (2) has further categorized undifferentiated carcinomas into sinonasal undifferentiated carcinoma (SNUC) and primary sinonasal nasopharyngeal-type undifferentiated carcinoma (PSNPC) which differ also in their association with Epstein-Barr Virus (EBV) infection and response to radiotherapy. Previous studies have demonstrated an association between EBV and development of SNUC, (3)(4)(5) however Cerilli et al (6) reported the absence of this association in their series of twenty five cases. The diagnosis of these tumours is difficult on the basis of light microscopic features, therefore, immunohistochemical analysis of undifferentiated carcinomas of the sinonasal region has proven helpful in distinguishing this heterogenous group of malignancies, guiding the multidisciplinary team of clinicians in its management (7).…”

Section: Introductionmentioning

confidence: 90%

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Epstein-Barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma: A distinct entity

Zahedi¹,

Hussin

Husain³

et al. 2017

Eastern J Med

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 90%

Epstein-Barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma: A distinct entity

Zahedi¹,

Hussin

Husain³

et al. 2017

Eastern J Med

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“…Conversely, LEC almost invariably arise in the nasopharynx, but histologically identical lesions may occur in the salivary gland or other "ectopic" sites in the ENT region. Confusion of such LEC with SNUC in the past has led to the erroneous belief that some SNUC were related to EBV (61)(62)(63)(64). Again, this is an important distinction because LEC has a better prognosis and is more responsive to radiation therapy than is SNUC.…”

Section: Large Cell Neuroendocrine Carcinomamentioning

confidence: 99%

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

2002

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Tumors exhibiting neuroectodermal differentiation occur throughout the body, and the diverse tissues of the head and neck give rise to a wide assortment of these neoplasms. Neuroectodermal neoplasms may be divided into lesions showing primarily epithelial differentiation (Group I, neuroendocrine carcinomas) and a more diverse group (Group II) of nonepithelial neoplasms. This article reviews these neuroectodermal tumors of the head and neck with emphasis on the neuroendocrine carcinomas and their nomenclature. The author believes that with regard to Group I tumors, the older terminology of carcinoid, atypical carcinoid, and small cell carcinoma should be replaced by subclassifications of well-differentiated, moderately differentiated, and poorly differentiated neuroendocrine carcinoma. The latter category should be further subdivided into small cell and large cell variants. Neuroendocrine carcinomas, particularly the moderately differentiated subtype, are often underdiagnosed in the head and neck region. In the larynx, these tumors are the most common form of nonsquamous carcinoma. Poorly differentiated neuroendocrine carcinoma of small cell type is most common in the salivary glands but can occur elsewhere in the region. The large cell subtype of poorly differentiated neuroendocrine carcinoma has not been well documented in this region. However, the most likely candidate for this tumor category is the so-called sinonasal undifferentiated carcinoma. Group II tumors discussed include olfactory neuroblastoma, malignant melanoma, and Ewing's sarcoma. In addition, differential diagnostic problems related to Group I and II tumors are reviewed in detail. This article reviews and updates our understanding of neuroectodermal neoplasms arising in the head and neck. The focus is on tumors that exclusively involve this region or show a strong predilection to occur here.

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“…The relationship to the Epstein-Barr virus (EBV) is somewhat controversial. Although two studies, one by Lopategui and associates 9 and another by Gallo and coworkers, 10 have suggested such a relationship; two further studies by Jeng and colleagues 11 and Cerilli et al, 12 using in situ hybridization, found no positivity for EBV in their patients with SNUC. Several series have been published, necessarily containing small numbers of patients due to the rarity of the disease, showing a dismal prognosis.…”

Section: Discussionmentioning

confidence: 97%

Sinonasal Undifferentiated Carcinoma with Intracranial Extension

Donald

2006

Skull Base

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Aim: To report our experience in the management of sinonasal undifferentiated carcinoma (SNUC) over a period of 15 years. Study design: A retrospective case review of 13 patients with SNUC treated at the University of California, Davis, Medical Center (UCDMC) Center for Skull Base Surgery, over the past 15 years. Results: Most tumors arose in the ethmoid sinuses. All but 1 patient had a combined intracranial-extracranial resection through the anterior fossa-transcranial route and postoperative irradiation. The 13th patient had a transfacial subcranial approach. There are 6 who have survived free of disease at 14 years' to 8 months' follow-up. The average follow-up was 6 years, 3 months. One patient died of a pulmonary embolism in the first postoperative week, a second died of a bowel infarction 3 months postoperatively. Three patients died of their disease at 20, 18, and 8 months postoperatively: 1 with local recurrence and distant metastasis and the other 2 with local control but distant disease. The 6 survivors are at 8, 20, 28, 62, 84, and 105 months. Conclusion: SNUC is a rare malignancy of the paranasal sinuses with a poor prognosis. Radical surgery and adjunctive therapy can achieve good survival in a significant proportion of patients who would hitherto have seemed incurable. KEYWORDS: Sinonasal undifferentiated carcinoma, malignancy, skull base surgerySinonasal undifferentiated carcinoma (SNUC) is an aggressive malignancy originating in the mucosa lining the walls of the nasal cavity and paranasal sinuses. It is a rare tumor that usually presents in an advanced stage, is highly invasive, and is traditionally reputed to be refractory to even the most radical therapy with an attendant poor prognosis. This is particularly true when it transgresses the cranial base. We present a personal series of 13 consecutive cases of SNUC with transgression of the skull base seen at the University of California Center for Skull Base Surgery, all of which were treated with curative intent by skull base surgery.

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Detection of Epstein-Barr Viral RNA in Sinonasal Undifferentiated Carcinoma from Western and Asian Patients

Cited by 74 publications

References 0 publications

Epstein-Barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma: A distinct entity

Epstein-Barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma: A distinct entity

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

Sinonasal Undifferentiated Carcinoma with Intracranial Extension

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