Detection of early cytokine storm in patients with septic shock after abdominal surgery

Abstract

Objectives: To explore the characteristics of cytokine storm in patients with septic shock after abdominal surgery, examine its relationship with clinical data, and determine intervention timings.Materials and Methods: We prospectively observed a cohort of patients with abdominal infection admitted to the surgical intensive care unit (ICU) after surgery (shock group). A control group of healthy individuals was used for comparison. Plasma samples and clinical data recorded at 0, 12, 24, 48, and 72 h after surgery were collected. Cytokines (tumor necrosis factor-α, interleukin [IL]-6, IL-8, IL-10, monocyte chemotactic protein [MCP]-1, IL-1 β, interferon-γ, IL-12p70, MCP-1α, IL-4, IL-2, and IL-13) were detected using the Luminex® technique.Results: Concentrations of most cytokines were significantly higher in the shock group. When a cytokine storm intensity curve was considered with the vasopressor dependency index and a Sequential Organ Failure Assessment (SOFA) score, time point of maximum cytokine storm intensity was earlier than that of the maximum vasopressor dependency index and SOFA score in the shock group.Conclusions: Cytokine storm occurred in patients with septic shock shortly after the abdominal surgery and may be a main mechanism leading to septic shock. Cytokine storm interventions should ideally be initiated within 24 h after surgery and be guided by cytokine storm biomarkers.

Indole-3-Propionic Acid as a Potential Therapeutic Agent for Sepsis-Induced Gut Microbiota Disturbance

“…An excessive proinflammatory response and/or exaggerated anti-inflammatory response further induce cellular dysfunction and death, ultimately resulting in multiorgan dysfunction syndrome and death ( 36 ). Similar to other studies ( 37 , 38 ), we also found that serum levels of the proinflammatory cytokines IL-1β and TNF-α were significantly elevated in septic mice ( Fig. 2G and H ).…”

Resistin as a Systemic Inflammation-Related Biomarker for Sarcopenia in Patients With Chronic Obstructive Pulmonary Disease

“…In addition, the serum resistin levels correlated with systemic inflammation, as indicated by the serum TNF-α level, in patients. TNF-α is an important pro-inflammatory cytokine ( 60 ). The elevated expression of TNF-α in muscle or circulatory system is associated with loss of muscle strength and muscle mass ( 61 ).…”

Atypical presentation of COVID‐19 infection as acute abdomen in children: A case series

“…An unnecessary surgery in such patients can lead to a cytokine storm and deterioration of patients’ condition. 12 Therefore, a decision for surgical approach should be taken with much caution and conservative treatment might be considered on admission. A multidisciplinary decision is necessary, and laboratory and imaging findings would help for a proper diagnosis and management.…”