Detection of Drugs of Abuse in Saliva by Surface-Enhanced Raman Spectroscopy (SERS)

Inscore, Frank; Shende, Chetan; Sengupta, Atanu; Huang, Hermes; Farquharson, Stuart

doi:10.1366/11-06310

Cited by 108 publications

(107 citation statements)

References 14 publications

Supporting

Mentioning

104

Contrasting

Unclassified

Order By: Relevance

“…Various methods have been utilized to measure glucose in vivo, 68 to immunolabel cancer cells, 69 to isolate and identify bacteria from blood infections, 70 and to detect drugs in saliva. 71 We will briefly describe a few of these applications, which we believe serve as good examples of the general sub-field. It has been found that certain molecules (those that are most easily capable of single molecule SERS) produce an extraordinarily large Raman enhancement in SERS.…”

Section: Light Scattering By Metal Nanoparticlesmentioning

confidence: 99%

“…77,78 In recent years, there have been a large number of explored biomedical applications that utilize SERS as a source of contrast. These applications range from isolated and detecting bacteria in blood for the purpose of improving the treatment of sepsis patients, 70 identifying proteins, 67 monitoring of blood glucose levels, 68 and detecting drugs in body fluids, 71,79 to name a few. The large amount of interest in the development of SERS techniques and their biomedical applications is a strong indicator of the vast potential of the phenomenon.…”

Section: Light Scattering By Metal Nanoparticlesmentioning

confidence: 99%

See 1 more Smart Citation

Spectroscopy of Scattered Light for the Characterization of Micro and Nanoscale Objects in Biology and Medicine

et al. 2014

View full text Add to dashboard Cite

The biomedical uses for the spectroscopy of scattered light by micro and nanoscale objects can broadly be classified into two areas. The first, often called light scattering spectroscopy (LSS), deals with light scattered by dielectric particles, such as cellular and sub-cellular organelles, and is employed to measure their size or other physical characteristics. Examples include the use of LSS to measure the size distributions of nuclei or mitochondria. The native contrast that is achieved with LSS can serve as a non-invasive diagnostic and scientific tool. The other area for the use of the spectroscopy of scattered light in biology and medicine involves using conducting metal nanoparticles to obtain either contrast or electric field enhancement through the effect of the surface plasmon resonance (SPR). Gold and silver metal nanoparticles are non-toxic, they do not photobleach, are relatively inexpensive, are wavelength-tunable, and can be labeled with antibodies. This makes them very promising candidates for spectrally encoded molecular imaging. Metal nanoparticles can also serve as electric field enhancers of Raman signals. Surface enhanced Raman spectroscopy (SERS) is a powerful method for detecting and identifying molecules down to single molecule concentrations. In this review, we will concentrate on the common physical principles, which allow one to understand these apparently different areas using similar physical and mathematical approaches. We will also describe the major advancements in each of these areas, as well as some of the exciting recent developments.Index headings: Light scattering; Spectroscopy; Nanoparticle; Surface plasmon; Surface enhanced Raman; SERS. INTRODUCTIONT he spectroscopy of scattered light has played an increasingly important role in biology and medicine because it can provide information about subcellular and extracellular biological structures using native contrast, as well as information about nanoparticles that are employed as the exogenous imaging markers or vehicles for the delivery of therapeutic agents. Light scattering by these microscopic objects is governed by the very basic principles of electromagnetic wave propagation and interaction with matter developed many decades ago. The impressive advances in biomedical instrumentation that have recently been achieved are examples of the successful applications of these fundamental principles. An analogy can be made between the development of biomedical light scattering and the development of other medical imaging modalities, for example the discovery of the very basic physics of X-rays led to the development of computed tomography decades later, while the initial understanding of another basic physical effect, nuclear magnetic resonance, eventually led to magnetic resonance imaging. Thus it can be argued that the field of biomedical optics is primarily concerned with the technological development of new medical applications of electromagnetic wave interactions, described by Maxwell's equations, with exogenous and endogenous...

show abstract

Section: Light Scattering By Metal Nanoparticlesmentioning

confidence: 99%

Section: Light Scattering By Metal Nanoparticlesmentioning

confidence: 99%

Spectroscopy of Scattered Light for the Characterization of Micro and Nanoscale Objects in Biology and Medicine

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Researchers have abtained SERS spectra of amphetamine, diazepam and methadone in saliva, 26 Clement Yuen 27 detected paclitaxel in blood plasma by SERS with a rather technically prepared substrate.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Drugs Illegally Added into Chinese Traditional Patent Medicine Using Surface-enhanced Raman Scattering

Zhang¹,

Huang

Liu

et al. 2013

ANAL. SCI.

View full text Add to dashboard Cite

Illegal chemicals, which could cause unpredictable side effects, may be added into traditional Chinese medicine (TCM) for a rapid healing effect. In this report, a surface-enhanced Raman scattering (SERS) analysis method for five kinds of illegally added drugs (rosiglitazone maleate, phenformin hydrochloride, metformin hydrochloride, pioglitazone hydrochloride and sibutramine hydrochloride) in Chinese traditional patent medicine (CTPM) has been demonstrated, including simultaneous detections of drug mixtures with CTPM. Silver colloidal, prepared by a sodium citrate reaction, was used as a SERS substrate. The optimum pH condition for each drug has also been explored because of its combined effect on protonation, surface charge, repulsion of an analyte and nanoparticles. Furthermore, the simultaneous detection of two or three kinds of these chemicals has been carried out. Characteristic peaks are employed for qualitative analysis. This is the first research using SERS for the analysis of drug mixtures in CTPM without any separation process.

show abstract

“…Typically, silver or gold nanostructured surfaces are used to enhance Raman spectra of molecules, with a sensitivity that reaches single‐molecule levels 4. This high sensitivity also makes it applicable in, for example, forensic trace detection5 or biomolecular assays 6. As SERS is highly confined to the metal surface, it allows for the selective study of the molecules in close proximity to the surface.…”

mentioning

confidence: 99%

Investigation of the Kinetics of a Surface Photocatalytic Reaction in Two Dimensions with Surface‐enhanced Raman Scattering

et al. 2014

View full text Add to dashboard Cite

Heterogeneous catalysis is a surface phenomenon. Yet, though the catalysis itself takes place on surfaces, the reactants and products rapidly take the form of another physical state, as either a liquid or a gas. Catalytic reactions within a self‐assembled monolayer are confined within two dimensions, as the molecules involved do not leave the surface. Surface‐enhanced Raman spectroscopy is an ideal technique to probe these self‐assembled monolayers as it gives molecular information in a measured volume limited to the surface. We show how surface‐enhanced Raman spectroscopy can be used to determine the reaction kinetics of a two‐dimensional reaction. As a proof of principle, we study the photocatalytic reduction of p‐nitrothiophenol. A study of the reaction rate and dilution effects leads to the conclusion that a dimerization must take place as one of the reaction steps.

show abstract

Detection of Drugs of Abuse in Saliva by Surface-Enhanced Raman Spectroscopy (SERS)

Cited by 108 publications

References 14 publications

Spectroscopy of Scattered Light for the Characterization of Micro and Nanoscale Objects in Biology and Medicine

Spectroscopy of Scattered Light for the Characterization of Micro and Nanoscale Objects in Biology and Medicine

Analysis of Drugs Illegally Added into Chinese Traditional Patent Medicine Using Surface-enhanced Raman Scattering

Investigation of the Kinetics of a Surface Photocatalytic Reaction in Two Dimensions with Surface‐enhanced Raman Scattering

Contact Info

Product

Resources

About