Detection of DNA strand breaks by fluroscence assisted DNA unwinding (FADU) assay in Hela cells treated with berbrine chloride before exposure to various doses of γ – radition
Abstract:The DNA damage plays an important role in the cell death and DNA double strand breaks in particular have been implicated in cell mortality. Therefore, the ability of berberine chloride to modulate radiation-induced DNA damage in HeLa cells exposed to different doses of γ-rays was studied by fluorescence assisted DNA unwinding assay. The spontaneous frequency of undamaged DNA remained unaltered in HeLa cells treated with 0, 1, 2, 4, 6 or 8µg/ml of BCL at 0, 0.25, 0.5, 1, 2 or 4h postirradiation. Immediate expos… Show more
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