Detection of DNA of Causative Agent of Spotted Fever Group Rickettsiosis in Japan from the Patient's Blood Sample by Polymerase Chain Reaction

Tange, Yoshiki; Matsumoto, Machiko; Okada, Takanori; Hasegawa, Hitoshi; Kobayashi, Yoshinari

doi:10.1111/j.1348-0421.1994.tb01837.x

Cited by 4 publications

(2 citation statements)

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“…The polymerase chain reaction (PCR) method, specific to strains isolated from the patients, has become available for the diagnosis of JSF. 11 One case could not be confirmed serologically because of death within 24 h of hospitalization, although it was diagnosed clinically through major symptoms of the disease. This case prompted us to develop a biopsy-based immunohistochemical method for early diagnosis of JSF.…”

Section: Serological Diagnosismentioning

confidence: 99%

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Rickettsioses in Japan and the Far East

Mahara¹

2006

Annals of the New York Academy of Sciences

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Three rickettsial diseases are known to exist in Japan currently: Japanese spotted fever (JSF), Tsutsugamushi disease (TD; scrub typhus), and Q fever. Since April 1999, the system for infection control and prevention in Japan has changed drastically. JSF, Q fever, and TD, as emerging infectious diseases, are designated as national notifiable diseases.The geographic distribution of JSF patients is along the coast of central and southwestern Japan, whereas TD and Q fever occur almost all over the country. The number of JSF patients reported was 216 cases during 1984-1998 and 268 cases, under the revised law, in 1999-2004. About 300-1000 cases of TD occur every year, and 7-46 cases of Q fever in 1999-2004. The number of cases of JSF and its endemic area are gradually increasing. There was only one fatality due to JSF until 2003, whereas two patients died of JSF in 2004, so JSF is still a life-threatening disease in Japan. Treatment of fulminant JSF consists of prompt administration of a combination of tetracycline and quinolone. Recent tick surveys revealed that the most probable vectors of JSF are Haemophysalis flava and Haemophysalis hystericis. In addition to R. japonica, two serotypes or species of spotted fever group rickettsiae have been isolated from ticks in Japan; one is closely related to R. helvetica and the other is a new genotype of unknown genotype AT, which is closely related to a Slovakian genotype. These serotypes are of uncertain clinical significance. Epidemiology of rickettsioses in the Far East is mentioned briefly.

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Section: Serological Diagnosismentioning

confidence: 99%

“…The polymerase chain reaction (PCR) method, specific to strains isolated from the patients, has become available for the diagnosis of JSF 11 …”

Section: Jsf and Tsutsugamushi Diseasementioning

confidence: 99%