Detection of dimethyl sulfone in the human brain by in vivo proton magnetic resonance spectroscopy

Rosea, Stephen E; Chalk, Jonathan B.; Galloway, Graham J.; Doddrell, David M.

doi:10.1016/s0730-725x(99)00110-1

Cited by 27 publications

(34 citation statements)

References 10 publications

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“…1). These data provide strong evidence for the assignment of DMSO 2 as source of the singlet x 14 . Furthermore, at pH 7.5, characteristic shifts were observed for the creatinine peak (3.13 at pH 2.5 to 3.05 ppm at pH 7.5) and citric acid [AB] 2 system (2.99, 2.83 ppm at pH 2.5-2.70; 2.54 ppm at pH 7.5).…”

Section: Identification Of Dmsomentioning

confidence: 54%

“…The major metabolites in this region and the chemical shifts at pH 2.5 are creatinine (singlet, 3.13 ppm), creatine (singlet, 3.05 ppm) and citric acid ([AB] 2 spin system, 2.99, 2.83 ppm). The singlet resonance at 3.14 ppm was observed in an earlier CSF study as unidentified resonance x 14 and was assigned to DMSO 2 as described below. 2 …”

Section: One-dimensional 1 H-nmr Spectroscopymentioning

confidence: 96%

“…Moreover, three papers have reported DMSO 2 in the human brain, as detected by in vivo 1 H-MRS. [12][13][14] In all cases the presence of this metabolite resulted from ingestion of a dietary supplement containing DMSO 2 . Milk 15 and port wine 16 are also possible sources of DMSO 2 , and we confirmed its presence in milk (20 mmol/l).…”

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confidence: 99%

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Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one‐dimensional ¹H and two‐dimensional ¹H‐¹³C NMR

et al. 2005

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(1)H-NMR spectroscopy at 500 MHz was used to confirm that a previously unidentified singlet resonance at 3.14 ppm in the spectra of cerebrospinal fluid and plasma samples corresponds to dimethyl sulfone (DMSO(2)). A triple resonance inverse cryogenic NMR probe, with pre-amplifier and the RF-coils cooled to low temperature, was used to obtain an (1)H-(13)C HSQC spectrum of CSF containing 8 microM (753 ng/ml) DMSO(2). The (1)H-(13)C correlation signal for DMSO(2) was assigned by comparison with the spectrum from an authentic reference sample. In plasma and CSF from healthy controls, the concentration of DMSO(2) ranged between 0 and 25 micromol/l. The concentration of DMSO(2) in plasma from three of four patients with severe methionine adenosyltransferase I/III (MAT I/III) deficiency was about twice the maximum observed for controls. Thus, DMSO(2) occurs as a regular metabolite at low micromolar concentrations in cerebrospinal fluid and plasma. It derives from dietary sources, from intestinal bacterial metabolism and from human endogenous methanethiol metabolism.

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Section: Identification Of Dmsomentioning

confidence: 54%

Section: One-dimensional 1 H-nmr Spectroscopymentioning

confidence: 96%

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Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one‐dimensional ¹H and two‐dimensional ¹H‐¹³C NMR

et al. 2005

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“…20 LCModel has been applied at 1.5 and 2.0 T to studies of epilepsy, 15,17,21,22 multiple sclerosis, [23][24][25] tumors, [26][27][28] Alzheimer's disease 29 and other pathologies, [30][31][32][33][34][35] including the identification and quantitation of unusual metabolites. 36,37 Many other applications of LCModel to childhood disorders can be found in a review article. 14 …”

Section: Applicationsmentioning

confidence: 99%

Automatic quantitation of localized in vivo¹H spectra with LCModel

2001

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The LCModel method analyzes an in vivo spectrum as a Linear Combination of Model in vitro spectra from individual metabolite solutions. Complete model spectra, rather than individual resonances, are used in order to incorporate maximum prior information into the analysis. A nearly model-free constrained regularization method automatically accounts for the baseline and lineshape in vivo without imposing a restrictive parameterized form on them. LCModel is automatic (non-interactive) with no subjective input. Approximately maximum-likelihood estimates of the metabolite concentrations and their uncertainties (Cramér-Rao lower bounds) are obtained. LCModel analyses of spectra from users with fields from 1.5 to 9.4 T and a wide range of sequences, particularly with short TE, are used here to illustrate the capabilities and limitations of LCModel and proton MRS.

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“…It is a symmetric molecule with no isomeric forms. Dimethyl sulfone has also been detected in the human brain [20], blood plasma, and cerebrospinal fluid [21] by proton magnetic resonance spectroscopy. Dimethyl sulfone is volatile, easily lost during cooking, and is believed to be non-toxic [22], [23].…”

Section: Discussionmentioning

confidence: 99%

GC/MS analysis and In-vitro Antioxidant activity of methanol extract of Ulothrix flacca and its main constituent Dimethyl Sulfone.

Vasudevarao¹,

Sravanthi²

2017

IOSRJPBS

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Detection of dimethyl sulfone in the human brain by in vivo proton magnetic resonance spectroscopy

Cited by 27 publications

References 10 publications

Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one‐dimensional ¹H and two‐dimensional ¹H‐¹³C NMR

Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one‐dimensional ¹H and two‐dimensional ¹H‐¹³C NMR

Automatic quantitation of localized in vivo¹H spectra with LCModel

GC/MS analysis and In-vitro Antioxidant activity of methanol extract of Ulothrix flacca and its main constituent Dimethyl Sulfone.

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Detection of dimethyl sulfone in the human brain by in vivo proton magnetic resonance spectroscopy

Cited by 27 publications

References 10 publications

Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one‐dimensional 1H and two‐dimensional 1H‐13C NMR

Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one‐dimensional 1H and two‐dimensional 1H‐13C NMR

Automatic quantitation of localized in vivo1H spectra with LCModel

GC/MS analysis and In-vitro Antioxidant activity of methanol extract of Ulothrix flacca and its main constituent Dimethyl Sulfone.

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Product

Resources

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Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one‐dimensional ¹H and two‐dimensional ¹H‐¹³C NMR

Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one‐dimensional ¹H and two‐dimensional ¹H‐¹³C NMR

Automatic quantitation of localized in vivo¹H spectra with LCModel