Detection of Differentially Expressed microRNAs in Serum of Pancreatic Ductal Adenocarcinoma Patients: miR-196a Could Be a Potential Marker for Poor Prognosis

Kong, Xiangyu; Du, Yiqi; Wang, Guokun; Gao, Jun; Yang, Gong; Li, Lei; Zhang, Zhuo; Zhu, Jiaqi; Jing, Qing; Qin, Yue; Li, Zhao‐Shen

doi:10.1007/s10620-010-1285-3

Cited by 140 publications

(126 citation statements)

References 33 publications

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“…In the present study, only miR-181b, miR-196a and miR-210 expression levels were significantly higher in the stool of the PCa group compared with the normal group. A similar result was also observed in our previous study (34), in which eight PCa tissue-specific microRNAs (miR-155, miR-16, miR-181a, miR-181b, miR-21, miR-196a, miR-222 and miR-221) were detected in the serum samples of PCa patients, but only three microRNAs (miR-21, miR-155 and miR-196a) were found to be overexpressed in patients with pancreatic diseases (including PCa and CP) compared with normal subjects. We hypothesize that there are two sources for microRNAs in stool samples: one from the tumor cells exfoliated from the tumor masses which are leaked into the digestive tract along with the pancreatic juice, and another from the tumor-derived exosomes in circulating blood which can be secreted into the digestive tract along with the gastrointestinal secretions with an active (selective) process.…”

Section: Discussionsupporting

confidence: 93%

Differential signature of fecal microRNAs in patients with pancreatic cancer

et al. 2012

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Abstract. The potential value of microRNAs as new biomarkers for pancreatic cancer (PCa) screening was explored in this study. Fecal microRNAs from stool samples obtained from 29 PCa patients, 22 chronic pancreatitis (CP) patients and 13 normal individuals were extracted, and 7 microRNAs (miR-16, miR-21, miR-155, miR-181a, miR-181b, miR-196a and miR-210) were detected. miR-181b and miR-210 discriminated PCa from normal individuals with receiver operating characteristic (ROC) curves and area under curve (AUC-ROC) of 0.745 and 0.772, respectively. There was a significant correlation between miR-196a and the maximum tumor diameter (Spearman r=0.516, P=0.041). These findings suggest that fecal microRNAs such as miR-181b and miR-210 may have potential to be used as new biomarkers for PCa screening.

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Section: Discussionsupporting

confidence: 93%

Differential signature of fecal microRNAs in patients with pancreatic cancer

et al. 2012

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“…After manually screening the titles, abstracts and key data, 259 records were excluded for not meeting the criteria listed above. Of the 28 reports selected for the systematic review, 12 studies were excluded in the final meta-analysis for lack of key HR value [21][22][23][24][25][26][27][28][29][30][31][32]. The excluded 12 studies commonly focused on other miRNAs and did not analyze the miR-155 data individually.…”

Section: Resultsmentioning

confidence: 99%

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

Zhang

et al. 2013

Disease Markers

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Abstract. BACKGROUND:Recent studies have shown that microRNAs (miRNA) have prognostic values in cancers. This meta-analysis seeks to summarize the global predicting role of miR-155 for survival in patients with a variety of carcinomas. METHODS: Eligible studies were identified through multiple search strategies. Data were extracted from studies investigating the relationship between miR-155 expression and survival in cancer patients. Combined hazard ratios (HRs) of miR-155 for outcome were analyzed. RESULTS: A total of 16 studies dealing with various carcinomas were included for this meta-analysis. For overall survival, higher miR-155 expression could significantly predict worse outcome with the pooled HR of 2.057 (95% CI: 1.392-3.039). For relapse or progress-free survival, elevated miR-155 was also a significant predictor, with a combined HR of 1.918 (95% CI: 1.311-2.806,). In addition, subgroup analysis showed that higher expression of miR-155 had the trends to predict worse outcome in lung cancer. However, the HRs did not reach the statistical significance. CONCLUSION: Our findings suggest that miR-155 detection has a prognostic value in cancer patients. Regularly measuring miR-155 expression may be useful in clinical practice.

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“…Currently three miR-196 members (miR-196a-1, miR-196a-2 and miR-196b) have been identified, and miR-196a genes are located within the HOX gene clusters (Chen et al, 2011). miR-196a has been reported to promote tumorigenesis in multiple types of cancers such as pancreatic cancer, glioma, lung cancer, and ovarian cancer (Kong et al, 2011;Liu et al, 2012;Yang et al, 2014;Fan et al, 2015). Furthermore, serum levels of miR-196a were significantly increased in patients with pancreatic cancer, and higher serum levels were associated with advanced clinical stage and shorter survival time (Kong et al, 2011).…”

Section: Introducationmentioning

confidence: 99%

“…miR-196a has been reported to promote tumorigenesis in multiple types of cancers such as pancreatic cancer, glioma, lung cancer, and ovarian cancer (Kong et al, 2011;Liu et al, 2012;Yang et al, 2014;Fan et al, 2015). Furthermore, serum levels of miR-196a were significantly increased in patients with pancreatic cancer, and higher serum levels were associated with advanced clinical stage and shorter survival time (Kong et al, 2011). The miR-196a gene polymorphism has also been shown to contribute to cancer risk and susceptibility (Dou et al, 2010;Lee et al, 2014), suggesting it has an oncogenic role during the development of cancer.…”

Section: Introducationmentioning

confidence: 99%

Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer

Liu¹,

Xin²,

F³

2015

Genet. Mol. Res.

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ABSTRACT. Previous studies have reported that miR-196a is upregulated in cervical cancer tissues and cell lines. However, whether serum miR196a is increased in patients with cervical cancer or cervical intraepithelial neoplasia (CIN), and its potential clinical value remained unknown. In total, 105 cervical cancer patients, 86 CIN patients, and 50 healthy volunteers were recruited. Quantitative reverse transcription-polymerase chain reaction was performed to compare the serum levels miR-196a in all participants. The associations between serum miR-196a and CIN grade/ clinicopathological parameters of cervical cancer were also examined. A survival analysis was performed using the Kaplan-Meier method. Univariate and multivariate analyses were conducted to explore the independent risk factors for cervical cancer. Our results revealed that serum miR196a levels were higher in patients with cervical cancer (P < 0.01) and CIN (P < 0.05) compared to those in healthy controls. Serum miR-196a was associated with CIN grade and various cervical cancer parameters including tumor size (P = 0.031), lymph node metastasis (P = 0.018),

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Detection of Differentially Expressed microRNAs in Serum of Pancreatic Ductal Adenocarcinoma Patients: miR-196a Could Be a Potential Marker for Poor Prognosis

Abstract: Serum miR-196a could be a potential noninvasive marker for PDAC prognosis and selection of laparotomy.

Cited by 140 publications

References 33 publications

Differential signature of fecal microRNAs in patients with pancreatic cancer

Differential signature of fecal microRNAs in patients with pancreatic cancer

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer

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