Detection of defective (T-antigen inducing, but noninfectious) particles in preparations of SV40 virus

Altstein, A. D.; Sarycheva, O.F.; Dodonova, N. N.

doi:10.1016/0042-6822(67)90075-x

Cited by 11 publications

(4 citation statements)

References 5 publications

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“…It was also observed that an interfering factor was present in the undiluted passage stock. This factor was thought to be The above findings are supported by more tenuous data from two other laboratories (92,93). Based only on immunofluorescence staining data, those authors also concluded that defective particles were present in their stocks of SV40.…”

Section: P Apovavirusesmentioning

confidence: 59%

Defective Dna Animal Viruses

Rapp¹

1969

Annu. Rev. Microbiol.

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Section: P Apovavirusesmentioning

confidence: 59%

Defective Dna Animal Viruses

Rapp¹

1969

Annu. Rev. Microbiol.

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“…Ordilnate: titer estimnate (ntumber ofplaques X dilutiont factor) /volume of inioculuhm. (1,2) Titrationt data of Ad2C8 virues in GMK cells without anid with cadcditioni of helper ade,ioviruts (Ad2), respectively. (3) Titrationt data of Ad2C8 virus in HEK cells.…”

Section: Resultsmentioning

confidence: 99%

Hybrid of Monkey and Human Adenoviruses

Altstein

Dodonova

Vassilyeva

et al. 1968

J Virol

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Following joint replication of monkey SA7 adenovirus (C8 strain) and human adenovirus type 2 in green monkey kidney tissue culture, a virus possessing the properties of a hybrid was obtained. It was designated Ad2C8. Ad2C8 preparations contained two types of viral particles: human adenovirus type 2, and hybrid particles. The hybrid virions multiplied in green monkey kidney cells in the presence of human adenovirus types 1, 2, and 3, but not 3 and 7, and acquired the capsid of the helper adenovirus. The hybrid can serve as a helper for human adenoviruses. It can apparently induce T antigen of the C8 virus but, in contrast to the latter, does not induce tumors in hamsters.

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“…The differences between SP and LP strains of polyoma virus have been shown to depend on a more active adsorption of the SP variant onto cells (Diamond and Crawford, 1964). The differences between the LP and SP strains of SV40 are due to a larger yield of infectious virus per cell in the case of the LP variants (Altstein et a/., 1966~;Takemoto et al, 1966;Koch and Eggers, 1967); and perhaps also associated with an increased formation of defective particles in the SP variants (Altstein et a/., 1967).…”

Section: Discussionmentioning

confidence: 99%

“…SV40, Rh2A426 strain, key kidney (GMK) cells were used. Growth has been described earlier (Altstein et al, 1967).…”

Section: Virusmentioning

confidence: 98%