Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy

Hakkola, Jukka; Raunio, Hannu; Purkunen, Raija; Pelkonen, Olavi; Saarikoski, Seppo; Cresteil, Thierry; Pasanen, Markku

doi:10.1016/0006-2952(96)00216-x

Cited by 147 publications

(69 citation statements)

References 17 publications

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“…During the first trimester of pregnancy, a broader variety of xenobiotic-metabolizing enzymes are expressed in the placenta as compared to at term [135,136] . However, placental expression of phaseⅠand Ⅱ metabolizing enzymes is moderate and probably more closely involved in the endocrine functions of this organ than in the metabolism of xenobiotics [135] .…”

Section: Metabolic Barriermentioning

confidence: 99%

“…However, placental expression of phaseⅠand Ⅱ metabolizing enzymes is moderate and probably more closely involved in the endocrine functions of this organ than in the metabolism of xenobiotics [135] . The placenta expresses several cytochrome P450 enzymes (CYPs) at mRNA levels that increase throughout pregnancy.…”

Section: Metabolic Barriermentioning

confidence: 99%

“…The placenta expresses several cytochrome P450 enzymes (CYPs) at mRNA levels that increase throughout pregnancy. Although placental CYPs are capable of metabolizing several xenobiotic compounds at term [135,136] , only a few of these enzymes are actually functionally active [137,138] . Moreover, the abundance of some of these CYPs has been shown to be affected by exposure to xenobiotics, as occurs in tobacco-smoking pregnant women [138,139] .…”

Section: Metabolic Barriermentioning

confidence: 99%

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Excretion of biliary compounds during intrauterine life

Macı́as¹,

Marin²,

Serrano³

2009

WJG

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In adults, the hepatobiliary system, together with the kidney, constitute the main routes for the elimination of several endogenous and xenobiotic compounds into bile and urine, respectively. However, during intrauterine life the biliary route of excretion for cholephilic compounds, such as bile acids and biliary pigments, is very poor. Although very early in pregnancy the fetal liver produces bile acids, bilirubin and biliverdin, these compounds cannot be efficiently eliminated by the fetal hepatobiliary system, owing to the immaturity of the excretory machinery in the fetal liver. Therefore, the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the placenta. Owing to the presence of detoxifying enzymes and specific transport systems at different locations of the placental barrier, such as the endothelial cells of chorionic vessels and trophoblast cells, this organ plays an important role in the hepatobiliary-like function during intrauterine life. The relevance of this excretory function in normal fetal physiology is evident in situations where high concentrations of biliary compounds are accumulated in the mother. This may result in oxidative stress and apoptosis, mainly in the placenta and fetal liver, which might affect normal fetal development and challenge the fate of the pregnancy. The present article reviews current knowledge of the mechanisms underlying the hepatobiliary function of the fetal-placental unit and the repercussions of several pathological conditions on this tandem.

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Section: Metabolic Barriermentioning

confidence: 99%

Section: Metabolic Barriermentioning

confidence: 99%

Section: Metabolic Barriermentioning

confidence: 99%

See 1 more Smart Citation

Excretion of biliary compounds during intrauterine life

Macı́as¹,

Marin²,

Serrano³

2009

WJG

View full text Add to dashboard Cite

show abstract

“…Before the discovery of antibodies specific for CYP1B1, mRNA expression had been detected in numerous tissues and cell types (15,(62)(63)(64)(65)(66). This could suggest a functional role for CYP1B1 in the bioactivation of numerous procarcinogens, including endogenous substrates, such as estrogens (7).…”

Section: Tissue-specific Expression In Normal and Neoplastic Tissuesmentioning

confidence: 99%

Pharmacogenetics and Regulation of Human CytochromeP450 1B1: Implications in Hormone-Mediated Tumor Metabolism and a Novel Target for Therapeutic Intervention

Sissung

Price

Sparreboom

et al. 2006

Molecular Cancer Research

135

128

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Several of the hormone-mediated cancers (breast, endometrial, ovarian, and prostate) represent major cancers in both incidence and mortality rates. The etiology of these cancers is in large part modulated by the hormones estrogen and testosterone. As advanced disease develops, the common treatment for these cancers is chemotherapy. Thus, genes that can alter tissue response to hormones and alter clinical response to chemotherapy are of major interest. The cytochrome P450 1B1 (CYP1B1) may be involved in disease progression and modulate the treatment in the above hormone-mediated cancers. This review will focus on the pharmacogenetics of CYP1B1 in relation to hormone-mediated cancers and provide an assessment of cancer risk based on CYP1B1 polymorphisms and expression. In addition, it will provide a summary of CYP1B1 gene regulation and expression in normal and neoplastic tissue. (Mol Cancer Res 2006;4(3):135 -50)

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“…CYP2E1 has also been detected in extrahepatic tissues. For example, the expression of CYP2E1 was detected in human placenta (114)(115)(116). CYP2E1 was also identified in prenatal human cephalic tissues (117).…”

Section: Analysis Of Variability and Susceptibilitymentioning

confidence: 98%

Human variability and susceptibility to trichloroethylene.

Pastino

Yap

Carroquino

2000

Environ Health Perspect

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Although humans vary in their response to chemicals, comprehensive measures of susceptibility have generally not been incorporated into human risk assessment. The U.S. EPA dose-response-based risk assessments for cancer and the RfD/RfC (reference dose-reference concentration) approach for noncancer risk assessments are assumed to protect vulnerable human subgroups. However, these approaches generally rely on default assumptions and do not consider the specific biological basis for potential susceptibility to a given toxicant. In an effort to focus more explicitly on this issue, this article addresses biological factors that may affect human variability and susceptibility to trichloroethylene (TCE), a widely used halogenated industrial solvent. In response to Executive Order 13045, which requires federal agencies to make protection of children a high priority in implementing their policies and to take special risks to children into account when developing standards, this article examines factors that may affect risk of exposure to TCE in children. The influence of genetics, sex, altered health state, coexposure to alcohol, and enzyme induction on TCE toxicity are also examined.

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Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy

Cited by 147 publications

References 17 publications

Excretion of biliary compounds during intrauterine life

Excretion of biliary compounds during intrauterine life

Pharmacogenetics and Regulation of Human CytochromeP450 1B1: Implications in Hormone-Mediated Tumor Metabolism and a Novel Target for Therapeutic Intervention

Human variability and susceptibility to trichloroethylene.

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