Detection of cystic fibrosis homozygotes and heterozygotes by serum isoelectrofocusing

Nevin, G. B.; Nevin, N. C.; Redmond, A. O. B.; Young, I. R.; Tully, Gillian

doi:10.1007/bf00274698

Cited by 20 publications

(9 citation statements)

References 9 publications

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“…(8) who reported a close correlation between insulin concentrations in human plasma and milk. Less information is available on the origin of EGF but it has been shown that radioactively labeled EGF can pass from the circulation into milk (4).…”

Section: Rcsponsc C F C U L T~~r C D Cell Lines To Inrzjin Utzd Egfmentioning

confidence: 99%

“…At resonant frequency, pressure and flow are in phase (zero phase angle). Total respiratory resistance can then be calculated from the relationship between pressure and flow, both measured at the mouth of the subject (4,5,7). The mathematical expression of pressure change across the respiratory system include:…”

Section: Measurement Of Total Respiratory Resistance Inmentioning

confidence: 99%

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Changes in the Growth-Promoting Activity of Human Milk during Lactation

et al. 1984

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Section: Rcsponsc C F C U L T~~r C D Cell Lines To Inrzjin Utzd Egfmentioning

confidence: 99%

Section: Measurement Of Total Respiratory Resistance Inmentioning

confidence: 99%

Changes in the Growth-Promoting Activity of Human Milk during Lactation

et al. 1984

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“…Epigenetic imprinting of genes in the Y chromosome around the time of puberty was thought to be responsible, [142] and changes in methylation levels of germ line or placenta may propagate the effects across generations. [250,262] Therefore, widespread smoking and exposure to second hand smoke may not only impact on those directly exposed to it, but also the health of successive generations through epigenetic reprograming that alters the growth and risks of diseases in offsprings. There may even be a multiplier effect since offsprings of smokers are more likely to take up smoking, [263] because then they will already be at an increased risk of smoking-related NCCDs due to prenatal exposure and their choice of smoking will greatly compound such risks.…”

Section: Smoking Alcohol Pollutants and Other Environmental Chemicalsmentioning

confidence: 99%

The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease

Imam

Ismail

2017

Global Challenges

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There are already extensive reviews on the global burden of NCCDs in the public domain. [1][2][3][4][5][6] The consensus that can be surmised from the available data on NCCDs is that their overall prevalence appears to be rising globally and the projections indicate an upward trend. Epidemiological transition data suggests that the morbidity and mortality rate from these diseases is far more than that of communicable diseases in the developed world [7] and a similar trend is now occurring in the low to medium income countries (LMICs). [8] Among the NCCDs, cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality, followed closely by metabolic diseases like Noncommunicable chronic diseases (NCCDs) are the leading causes of morbidity and mortality globally. The mismatch between present day diets and ancestral genome is suggested to contribute to the NCCDs burden, which is promoted by traditional risk factors like unhealthy diets, physical inactivity, alcohol and tobacco. However, epigenetic evidence now suggests that cumulatively inherited epigenetic modifications may have made humans more prone to the effects of present day lifestyle factors. Perinatal starvation was widespread in the 19th century. This together with more recent events like increasing consumption of western and low fiber diets, smoking, harmful use of alcohol, physical inactivity, and environmental pollutants may have programed the human epigenome for higher NCCDs risk. In this review, on the basis of available epigenetic data it is hypothesized that transgenerational effects of lifestyle factors may be contributing to the current global burden of NCCDs. Thus, there is a need to reconsider prevention strategies so that the subsequent generations will not have to pay for our sins and those of our ancestors. Cardiovascular DiseasesDr. M. U. Imam

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“…Some controversy has occurred over the existence of the so-called cystic fibrosis protein (CFP) (Smith et al, 1976;Thomas et al, 1977;Scholey et al, 1978;Tully et al, 1979;Hallinan et al, 1981;Nevin et al, 1981;Brock et al, 1982), but more recently CFP has been shown to be present in plasma samples as well as in sera (Gratar01i et al, 1984;Wilson et al, 1985). Super MS received 12.2.86 Accepted 23.4.86 and Swindlehurst (1984) have reported the use of IEF of serum samples to assist their genetic counselling of relatives of children with CF, and their spouses.…”

mentioning

confidence: 99%

Identification of cystic fibrosis homozygotes and heterozygotes by isoelectric focussing of serum proteins

Getliffe

Ward

Shepherd

1986

J of Inher Metab Disea

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Screening of 44 cystic fibrosis homozygotes, 17 heterozygotes and 36 normal controls, by identification of cystic fibrosis protein (CFP), was performed on sera using an improved isoelectric focusing technique. CFP was observed in 91% of homozygotes, 88% of heterozygotes and 8% of normal controls tested. Partial purification of CFP by chromatofocussing indicates that CFP has a molecular weight of about 52,000 u. It is speculated that CFP is a normal serum protein that exhibits a quantitative difference in concentration between CF homozygotes, heterozygotes and normals.

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Detection of cystic fibrosis homozygotes and heterozygotes by serum isoelectrofocusing

Cited by 20 publications

References 9 publications

Changes in the Growth-Promoting Activity of Human Milk during Lactation

Changes in the Growth-Promoting Activity of Human Milk during Lactation

The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease

Identification of cystic fibrosis homozygotes and heterozygotes by isoelectric focussing of serum proteins

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