Detection of CYP1A1 and GSTP1 gene polymorphisms in bladder cancer patients in a Turkish population using a polymerase chain reaction-restriction fragment length polymorphism method

Analysis of polymorphic gene loci of antioxidant protection enzymes in three ethnic groups of the Republic of Bashkortostan

“…Анализ полиморфных локусов генов GSTP1 (g.67585218A>G, р.Ile105Val, rs1695; g.7514C>T, р.Ala114Val, rs1138272), CAT (с.-262C>T, g.4760C>T, rs1001179; c.1167C>T, g.27437C>T, p.Asp389, rs769217), GPX1 (g.5958C>T, p.Pro200Leu, rs1050450), NQO1 (c.465C>T, g.16665C>T, p.Arg139Trp, rs1131341; c.609C>T, g.20389C>T, p.Pro187Ser, rs1800566) проводили методом полимеразной цепной реакции (ПЦР) с последующей рестрикцией соответствующими ферментами (BsoMAI, BstFNI, SmaI, BstXI, BstDEI, MspI, HIinfI) производства "Сибэнзим" (Россия) и "Fermentas". Делеционный полиморфизм генов GSTM1 (del), GSTT1 (del) исследовали в стандартных условиях по ранее описанной методике [3,4]. Последовательности олигонуклеотидных праймеров и методы идентификации полиморфных аллелей изученных полиморфизмов были приведены ранее в работах [3][4][5][6][7][8][9][10][11].…”

“…Делеционный полиморфизм генов GSTM1 (del), GSTT1 (del) исследовали в стандартных условиях по ранее описанной методике [3,4]. Последовательности олигонуклеотидных праймеров и методы идентификации полиморфных аллелей изученных полиморфизмов были приведены ранее в работах [3][4][5][6][7][8][9][10][11].…”

Molecular Detection of Genetic Susceptibility to Bladder Cancer in Egyptian Patients

“…It occurs in both sexes, there is a male predominance, and it ranked 7th in terms of occurrence for men (Rampias et al, 2014). Bladder cancer varies among countries, with the highest incidence rates in Europe, the United States and Egypt, whereas the lowest rates in Asia and Africa, it is known of a cancer of industrialized nations, with higher incidence in high resource versus low resource countries, determined as high as triple fold (Altunkol, et al, 2018). Cigarette smoke and occupational exposures are examples of two well-established factors in the development of bladder cancer.…”

Polymorphism of Biotransformation Genes of Xenobiotics Gstm1 and Gstt1 of Probable Markers of Risk of Lung Oncology, in the Yakut Population

“…Measuring of the level of oxidized and reduced glutathione and other thiols and disulfides in tissues and blood is a sensitive marker of disturbances of the redox balance. Nevertheless, methodical approaches to their estimation require careful observation of the storage and sample preparation conditions for biological material for analysis, the choice of an optimal, specific, sensitive analytical method giving well-reproducible results [1,2].…”