Detection of Crimean Congo haemorrhagic fever virus in North-eastern Senegal, Bokidiawé 2019

Dieng, Idrissa; Barry, Mamadou Aliou; Diagne, Moussa Moïse; Diop, Boly; Ndiaye, Mamadou; Faye, Martin; Ndione, Marie Henriette Dior; Dieng, Mame Malick; Bousso, Abdoulaye; Fall, Gamou; Loucoubar, Cheikh; Sall, Amadou Alpha; Faye, Oumar; Faye, Ousmane

doi:10.1080/22221751.2020.1847605

Cited by 13 publications

(13 citation statements)

References 16 publications

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“…Here we describe for the first time the detection of several WNV human cases in Senegal, associated with a strong detection of the virus in the mosquito vector. Indeed, the improvement of arbovirus surveillance in Senegal with the implementation of the 4S system and new diagnostic tools made it possible to highlight the circulation of many arboviruses including dengue, Crimean-Congo hemorrhagic fever, Rift Valley fever and WNV viruses in humans as well as in arthropods [43,44,65,66]. Before the implementation of the 4S network for arboviruses surveillance, WNV detection in humans was limited to two cases detected in Dakar in 1970 and 1991 [41].…”

Section: Discussionmentioning

confidence: 99%

Re-Introduction of West Nile Virus Lineage 1 in Senegal from Europe and Subsequent Circulation in Human and Mosquito Populations between 2012 and 2021

Ndione

Ndiaye

Faye

et al. 2022

Viruses

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West Nile virus (WNV) is a virus of the Japanese encephalitis antigenic complex and belongs to the family Flaviviridae of the genus flavivirus. The virus can cause infection in humans which in most cases is asymptomatic, however symptomatic cases exist and the disease can be severe causing encephalitis and meningoencephalitis. The virus is maintained in an enzootic cycle involving mosquitoes and birds, humans and other mammals such as horses can be accidental hosts. A mosquito-based arbovirus surveillance system and the sentinel syndromic surveillance network (4S) have been in place since 1988 and 2015 respectively, to better understand the transmission dynamics of arboviruses including WNV in Senegal. Arthropod and human samples have been collected from the field and analysed at Institut Pasteur de Dakar using different methods including RT-PCR, ELISA, plaque reduction neutralization test and viral isolation. RT-PCR positive samples have been analysed by Next Generation Sequencing. From 2012 to 2021, 7912 samples have been analysed and WNV positive cases have been detected, 20 human cases (19 IgM and 1 RT-PCR positive cases) and 41 mosquito pools. Phylogenetic analyzes of the sequences of complete genomes obtained showed the circulation of lineage 1a, with all these recent strains from Senegal identical to each other and very close to strains isolated from horse in France in 2015, Italy and Spain. Our data showed lineage 1a endemicity in Senegal as previously described, with circulation of WNV in humans and mosquitoes. Phylogenetic analyzes carried out with the genome sequences obtained also revealed exchanges of WNV strains between Europe and Senegal which could be possible via migratory birds. The surveillance systems that have enabled the detection of WNV in humans and arthropods should be extended to animals in a one-health approach to better prepare for global health threats.

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Section: Discussionmentioning

confidence: 99%

Re-Introduction of West Nile Virus Lineage 1 in Senegal from Europe and Subsequent Circulation in Human and Mosquito Populations between 2012 and 2021

Ndione

Ndiaye

Faye

et al. 2022

Viruses

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“…However, since the implementation of the arbovirus testing in the 4S network in 2015, better detection of many arboviruses including RVFV, Crimean Congo hemorrhagic fever virus [ 32 ], Dengue virus [ 33 ], and West Nile virus (unpublished data) has been observed. Indeed, in 2020, 9 RVFV human cases were detected in different areas in Senegal, such as the Fatick, Matam, Saint-Louis, and Dakar regions.…”

Section: Discussionmentioning

confidence: 99%

Detection of Rift Valley Fever Virus Lineage H From South Africa Through the Syndromic Sentinel Surveillance Network in Senegal

Bob

Barry

Diagne

et al. 2021

Open Forum Infectious Diseases

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Background Rift Valley fever virus (RVFV) is an arbovirus that causes epizootics and epidemics among livestock population and humans. Our surveillance system has revealed multiple emergences and re-emergences of RVFV in West Africa over the last decade. Methods In Senegal a sentinel syndromic surveillance network (4S) has been implemented since 2011. Samples from human suspected arbovirus infection in 4S sentinel sites were sent to Institut Pasteur de Dakar (IPD) where arbovirus diagnosis by enzyme-linked immunosorbent assay (ELISA), real-time reverse transcription polymerase chain reaction (RT-PCR), and virus isolation were performed. Overall, IPD has received a total of 1,149 samples from arboviral suspected patients through the 4S network from January to December 2020. These samples were screened for seven arboviruses including RVFV. Whole genome sequencing of positive RVFV samples by RT-PCR were performed using Illumina Miseq platform followed by genome assembly. Phylogenetic analysis were performed using MEGA X. Results Out of the 1,149 arbovirus suspected cases, four RVFV positive samples were detected with RT-PCR while five RVFV positive samples were detected by ELISA. Complete genome sequences were obtained for three strains among the four positive samples by RT-PCR. Phylogenetic analyses indicated an emergence of a virus first described in South Africa during a major outbreak. Conclusion Strong surveillance system allowed the detection of RVFV outbreak in Senegal in 2020. The obtained genomes clustered with strains from South Africa belonging to lineage H. This calls for an implementation of a strong surveillance system in wild animals, humans, and livestock simultaneously in all African Countrries.

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“…Epidemiological and environmental data show that Senegal northern regions are the most exposed [ 9 , 10 ]. Additionally, the last human case was reported in 2019 in Bokidiawe (northern Senegal) [ 11 ].…”

Section: The Studymentioning

confidence: 99%

Multiple genotypes of Crimean-Congo hemorrhagic fever virus detected in ticks during a one health survey in Agnam, Northeastern Senegal

Mhamadi

Badji

Dieng

et al. 2022

Emerging Microbes & Infections

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Detection of Crimean Congo haemorrhagic fever virus in North-eastern Senegal, Bokidiawé 2019

Cited by 13 publications

References 16 publications

Re-Introduction of West Nile Virus Lineage 1 in Senegal from Europe and Subsequent Circulation in Human and Mosquito Populations between 2012 and 2021

Re-Introduction of West Nile Virus Lineage 1 in Senegal from Europe and Subsequent Circulation in Human and Mosquito Populations between 2012 and 2021

Detection of Rift Valley Fever Virus Lineage H From South Africa Through the Syndromic Sentinel Surveillance Network in Senegal

Multiple genotypes of Crimean-Congo hemorrhagic fever virus detected in ticks during a one health survey in Agnam, Northeastern Senegal

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