Detection of colostrum-derived alloantibodies in calves with bovine neonatal pancytopenia

Bridger, P.; Bauerfeind, Rolf; Wenzel, Lisa; Bauer, Natali; Menge, Christian; Thiel, Heinz-Jürgen; Reinacher, M.; Doll, K.

doi:10.1016/j.vetimm.2011.01.001

Cited by 26 publications

(43 citation statements)

References 8 publications

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“…This is also in accordance with previous reports where BNP was induced by ingestion of colostrum (6,7). In the field, the variability of the Ab concentration in the colostrum, the quantity of ingested colostrum, and the rate of absorption through the digestive tract may modulate the total amount of acquired alloantibodies and expression of the disease.…”

Section: Discussionsupporting

confidence: 93%

“…Conversely, when BNP-dam blood cells were assayed, no staining was detected. Altogether, our data indicate that IgG from BNP dams recognizes one or several blood cell surface Ag(s), as has been previously suggested by others in studies of sera from BNP dams (9) or of BNP induced in calves by administration of colostrum from BNP dams (6). Thus, BNP is an alloimmune response in which cows produce Abs against one or several determinant(s), hypothetically of paternal origin, widely expressed on calf blood cells and platelets.…”

Section: Igg Recognizes Mhc Class I On Blood Leukocytes and Plateletssupporting

confidence: 85%

“…Their WBC and platelet counts (Fig 1A, 1B) and bone marrow composition progressively returned to normal within 1 mo. The clinical and biological signs of the IgG-injected animals that manifested disease were the same as those reported in natural (1, 2) and colostrum-induced BNP cases (6,7). Our data unequivocally show that IgG collected from BNP dams can induce de novo BNP in unrelated newborn calves.…”

Section: Purified Igg From Bnp Dams Induces Thrombocytopenia and Leuksupporting

confidence: 84%

“…BNP has been produced experimentally in some calves through ingestion of particular colostrums (6,7), indicating that immune effectors might be involved. Colostrum has a high concentration of IgG (between 50 and 200 g/l) and provides the calf with its sole source of passive immunity in the first hours of life.…”

Section: S Ince 2007 An Emergent Life-threatening Disease Of Neonatalmentioning

confidence: 99%

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Alloantibodies against MHC Class I: A Novel Mechanism of Neonatal Pancytopenia Linked to Vaccination

Foucras

Corbière

Tasca

et al. 2011

The Journal of Immunology

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Fetal/neonatal alloimmune thrombocytopenia is a frequent disease in humans where alloantibodies against platelet Ags lead to platelet destruction and hemorrhage. Although a role in the disease for Abs against MHC has been suspected, this has not been formally demonstrated. Since 2007, a hemorrhagic syndrome due to thrombocytopenia and designated as bovine neonatal pancytopenia (BNP) has been recognized in calves in several European countries. An inactivated antiviral vaccine is strongly suspected to be involved in this syndrome because of its highly frequent use in the dams of affected calves. In this study, we show that BNP is an alloimmune disease, as we reproduced the signs by transferring serum Abs from vaccinated BNP dams into healthy neonatal calves. Ab specificity was strongly associated with the presence of allogeneic MHC class I Abs in the dams. MHC class I staining was also observed on Madin–Darby bovine kidney cells, a cell line related to the one used to produce the vaccine Ag. Our report emphatically demonstrates that alloimmunization against MHC class I is associated with a substantial risk of developing cytopenia-associated syndromes in neonates when a cell line of the same species is used to produce an inactivated vaccine injected into the mother.

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Section: Discussionsupporting

confidence: 93%

Section: Igg Recognizes Mhc Class I On Blood Leukocytes and Plateletssupporting

confidence: 85%

Section: Purified Igg From Bnp Dams Induces Thrombocytopenia and Leuksupporting

confidence: 84%

Section: S Ince 2007 An Emergent Life-threatening Disease Of Neonatalmentioning

confidence: 99%

See 2 more Smart Citations

Alloantibodies against MHC Class I: A Novel Mechanism of Neonatal Pancytopenia Linked to Vaccination

Foucras

Corbière

Tasca

et al. 2011

The Journal of Immunology

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“…Early investigations found that colostrum obtained from cows that had previously given birth to a BNP-affected calf (BNP cows) causes BNP when fed to unrelated newborn calves [15][16][17][18]. Furthermore, serum and colostrum from BNP cows were shown to contain alloantibodies that bind to peripheral blood leukocytes, platelets and bone marrow cells [9,11,12,[18][19][20][21], and intravenous infusion of these antibodies was sufficient to induce the disease [9].…”

Section: Bnp Is An Alloimmune Disease Induced By Antibodies Absorbed mentioning

confidence: 99%

The risks of using allogeneic cell lines for vaccine production: the example of Bovine Neonatal Pancytopenia

Benedictus

Bell

2016

Expert Review of Vaccines

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Introduction: Bovine neonatal pancytopenia (BNP) is a hemorrhagic disease that emerged in calves across Europe in 2007. Its occurrence is attributed to immunization of the calf's mother with a vaccine produced using an allogeneic cell line. Vaccine-induced alloantibodies specific for major-histocompatibility class I antigens are transferred from the mother to the calf via colostrum, leading to profound depletion of peripheral blood and bone marrow cells that is often fatal. Areas covered: Pubmed and Web of Science were used to search for literature relevant to BNP and the use of allogeneic vaccine cell lines. Following a review of the pathology and pathogenesis of this novel condition, we discuss potential risks associated with the use of allogeneic vaccine cell lines. Expert commentary: Although BNP is associated with a specific vaccine, it highlights safety concerns common to all vaccines produced using allogeneic cell lines. Measures to prevent similar vaccineinduced alloimmune-mediated adverse events in the future are discussed.

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Bovine neonatal pancytopenia (BNP): novel insights into the incidence, vaccination-associated epidemiological factors and a potential genetic predisposition for clinical and subclinical cases

Demasius

Weikard

Kromik

et al. 2014

Research in Veterinary Science

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Detection of colostrum-derived alloantibodies in calves with bovine neonatal pancytopenia

Cited by 26 publications

References 8 publications

Alloantibodies against MHC Class I: A Novel Mechanism of Neonatal Pancytopenia Linked to Vaccination

Alloantibodies against MHC Class I: A Novel Mechanism of Neonatal Pancytopenia Linked to Vaccination

The risks of using allogeneic cell lines for vaccine production: the example of Bovine Neonatal Pancytopenia

Bovine neonatal pancytopenia (BNP): novel insights into the incidence, vaccination-associated epidemiological factors and a potential genetic predisposition for clinical and subclinical cases

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