Detection of colored nanomaterials using evanescent field-based waveguide sensors

Fujimaki, Makoto; Nomura, Kohji; Sato, Kazuki; Kato, Takafumi; Gopinath, Subash C.B.; Wang, Xiaomin; Awazu, Kunio; Ohki, Yoshimichi

doi:10.1364/oe.18.015732

Cited by 45 publications

(51 citation statements)

References 27 publications

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“…6). As shown by Lakshmipriya et al [7], this strategy is more suitable for other novel high performance sensors that have been proposed for bio-recognitions [42][43][44][45]. In conclusion, the present findings collectively contribute to a deeper understanding of the bio-fouling associated with various metal substrates utilized for biosensor engineering.…”

Section: Conclusion and Future Prospectssupporting

confidence: 65%

Investigation on Optimally Performing Sensor Substrates through Bio-fouling of Immunoglobulin-Conjugated Gold Nanoparticles

Gopinath

Kumaresan

Nishimura

et al. 2015

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.

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Biosensing technology represents a superior way of identifying a wide range of biomolecules that exist in the human body, food, water, and other environmental sources. In this regard, human health issues are a growing global concern, and the development of effective methods for the detection and differentiation of biomolecules during diagnosis and/or treatment of diseases is essential. However, achieving adequate levels of sensitivity and specificity will be fundamental for the successful clinical application of biosensing technology. Notably, sensitivity and specificity are highly dependent on non-fouling (specificity) of biomolecules on the sensing surfaces, particularly with regard to nanoparticle-tagged biomolecules. Here, the authors have evaluated bio-fouling (i.e., biological non-specificity) by analysing four distinct sensing substrates (gold, silicon, silica and platinum) using anti-mouse immunoglobulin-conjugated gold nanoparticles. As evidenced by scanning electron microscopy and ultraviolet-visible-near-infrared recording spectrophotometry, silica (SiO 2 ) lacked bio-fouling, whereas gold (Au) showed high bio-fouling potential. Indeed, Raman spectroscopic analysis further confirmed these results. Thus, the present findings indicate that SiO 2 is an optimal substrate for biosensor development.

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Section: Conclusion and Future Prospectssupporting

confidence: 65%

Investigation on Optimally Performing Sensor Substrates through Bio-fouling of Immunoglobulin-Conjugated Gold Nanoparticles

Gopinath

Kumaresan

Nishimura

et al. 2015

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.

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“…Using forceps, sterile filter paper discs were transferred onto the surface of the agar plate carefully. The filter paper discs were labeled properly, and each filter paper disc was loaded with different amounts of solutions (20,25,30,35,40, and 45 µL) from the dilutions made. Then, the agar plates were placed in the incubator set at 37°C overnight and monitored on the next day.…”

Section: Disc Diffusion Methods and Determination Of Minimum Inhibitormentioning

confidence: 99%

“…It is widely accepted that metal nanoparticles are harmful to fungi and bacteria [40], and this characteristic allows them to adhere with cell wall of microorganisms, resulting in the destruction and death of the cell. In this study, different concentrations (20,25,30,35,40, and 45 µg) of herbal extracts were tested. The MIC was determined at 45 ug and it was compared with the conjugation with GNPs (Figs.…”

Section: Antimicrobial Activity Of Herbal Extract and Gnp Conjugatementioning

confidence: 99%

“…Various metallic nanoparticles such as, platinum, silver, and gold were focused recently because of their requisite importance [23,24]. Among the previously mentioned metal nanoparticles, gold nanoparticle (GNP) is more vital because of its history in medicinal application, e.g., treatment of cancer and arthritis with conjugated GNP and also due to their biocompatibility [25][26][27][28][29]. In this research, GNP was purchased, and compounds of A. paniculata herbal plant leaf were captured on the GNP.…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Potential of Andrographis paniculata Conjugated Gold Nanoparticle

Razalli¹,

Gopinath²,

Kasim³

et al. 2019

INNOCS Theranos Pharmco Sci

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Background: Herbal extracts have been traditionally used as antibacterial agents, and different strategies have been proposed to enhance their antimicrobial activities. This research aimed to assess the antimicrobial potential of Andrographis paniculata conjugated gold nanoparticle (GNP) compounds against Escherichia coli and Bacillus subtilis.Methods: Herbal extract was conjugated with GNP through electrostatic interaction, and characterization was carried out by Fourier-transmission infrared spectroscopy, screening electron microscopy, and transmission electron microscopy and supported by energy-dispersive X-ray spectroscopy. Antibacterial activity of the herbal extract and GNP conjugation was evaluated by disc diffusion assay.Results: Chemical and morphological characterizations of the GNP and herbal extract conjugate revealed intactness of the GNP. In disc diffusion assay, the inhibition zone formed by these compounds was measured for both microorganisms, and they were in the range of 0.6-0.9 cm for the herbal extract. When the herbal extract conjugated with GNP, the zone was between 0.8 and 1.1 cm.Conclusion: This study demonstrated the potentiality of GNP to carry the antibacterial compounds from the herbal extract.

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“…This surfactant sensor was developed on the basis of waveguide-mode sensor technology. (2)(3)(4)(5)(6) The sensing plate of a waveguide-mode sensor incorporates a thin single-crystalline Si layer and a thin SiO 2 glass layer on a silica glass substrate. It has been reported that the sensor sensitivity can be improved by forming nanopores on the thin SiO 2 layer.…”

Section: Introductionmentioning

confidence: 99%

Surfactant Sensor Based on Waveguide-mode Sensor with Hydrophobic Perforated Surface

Fujimaki¹,

Ashiba²

2019

Sensors and Materials

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The sensitivity of a waveguide-mode sensor, which has a sensing plate incorporating a thin single-crystalline Si layer and a thin SiO 2 glass layer on a silica glass substrate, can be improved by increasing the surface area of the thin SiO 2 glass layer by forming nanopores. In this study, we achieved the highly sensitive detection of surfactants in water by hydrophobic treatment of the surface of the sensing plate on which nanopores were formed. The hydrophobic treatment ensures that no water enters the nanopores, even when the sensing plate surface is immersed. When a surfactant is present in the water, the surfactant is gradually adsorbed on the sensing plate surface, which leads to hydrophilization; the water can then enter the nanopores. This results in a large refractive index variation on the chip surface, which makes it possible to detect the surfactant with high sensitivity. 0.02 mg/l Tween 20, which is a nonionic surfactant, and 0.02 mg/l sodium dodecyl sulfate, which is an anionic surfactant, were successfully detected using this sensor.

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Detection of colored nanomaterials using evanescent field-based waveguide sensors

Cited by 45 publications

References 27 publications

Investigation on Optimally Performing Sensor Substrates through Bio-fouling of Immunoglobulin-Conjugated Gold Nanoparticles

Investigation on Optimally Performing Sensor Substrates through Bio-fouling of Immunoglobulin-Conjugated Gold Nanoparticles

Antimicrobial Potential of Andrographis paniculata Conjugated Gold Nanoparticle

Surfactant Sensor Based on Waveguide-mode Sensor with Hydrophobic Perforated Surface

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