Detection of colon cancer by continuous-wave terahertz polarization imaging technique

Doradla, Pallavi; Alavi, Karim; Joseph, Cecil S.; Giles, Robert H.

doi:10.1117/1.jbo.18.9.090504

Cited by 110 publications

(69 citation statements)

References 11 publications

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“…For THz reflection image, the reflected signal is measured on the same side as the incident signal. This is accomplished either by setting the incident and reflection signals at an oblique angle or by using a beamsplitter in order to separate the incident and reflected signals when both occur at normal incidence [14].…”

Section: Introductionmentioning

confidence: 99%

“…As a result, THz imaging has shown promise in assessment of burns [9], liver cirrhosis [10], and tissue damage from myocardial infarction [11]. Most notably, THz imaging has been applied to detecting and assessing regions of cancer in healthy tissue for a wide range of cancers including cancer of the skin [12,13], liver [11], colon [14], brain [15], and breast [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Terahertz transmission vs reflection imaging and model-based characterization for excised breast carcinomas

Bowman

El-Shenawee

Campbell

2016

Biomed. Opt. Express

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This work presents experimental and analytical comparison of terahertz transmission and reflection imaging modes for assessing breast carcinoma in excised paraffinembedded human breast tissue. Modeling for both transmission and reflection imaging is developed. The refractive index and absorption coefficient of the tissue samples are obtained. The reflection measurements taken at the system's fixed oblique angle of 30° are shown to be a hybridization of TE and TM modes. The models are validated with transmission spectroscopy at fixed points on fresh bovine muscle and fat tissues. Images based on the calculated absorption coefficient and index of refraction of bovine tissue are successfully compared with the terahertz magnitude and phase measured in the reflection mode. The validated techniques are extended to 20 and 30 μm slices of fixed human lobular carcinoma and infiltrating ductal carcinoma mounted on polystyrene microscope slides in order to investigate the terahertz differentiation of the carcinoma with non-cancerous tissue. Both transmission and reflection imaging show clear differentiation in carcinoma versus healthy tissue. However, when using the reflection mode, in the calculation of the thin tissue properties, the absorption is shown to be sensitive to small phase variations that arise due to deviations in slide and tissue thickness and non-ideal tissue adhesion. On the other hand, the results show that the transmission mode is much less sensitive to these phase variations. The results also demonstrate that reflection imaging provides higher resolution and more clear margins between cancerous and fibroglandular regions, cancerous and fatty regions, and fibroglandular and fatty tissue regions. In addition, more features consistent with high power pathology images are exhibited in the reflection mode images.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Terahertz transmission vs reflection imaging and model-based characterization for excised breast carcinomas

Bowman

El-Shenawee

Campbell

2016

Biomed. Opt. Express

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“…2 Recently, colon and skin studies (at 584 GHz frequency) have indicated that reflection-based polarization sensitive continuous-wave (CW) THz imaging is capable of detecting intrinsic contrast between cancerous and normal tissues based on water content combined with structural changes. 3,4 Endoscopy is a minimally invasive diagnostic medical procedure to examine the interior surfaces of an organ or tissue without surgery. Besides conventional endoscopy, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) are current diagnostic imaging modalities for the detection of local and distant relapse of cancer.…”

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confidence: 99%

Single-channel prototype terahertz endoscopic system

et al. 2014

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“…Most of them were based on the pulsed THz time-domain spectroscopic imaging [3][4][5][6]. Pallavi Doradla et al presented some reflection measurements of 5-mm-thick sections of colorectal tissues using a polarization-specific detection technique based on continuous wave (CW) terahertz source [7]. THz polarization imaging provides more information on the measured targets.…”

Section: Introductionmentioning

confidence: 99%

“…THz imaging has the advantage to penetrate most of non-metal and non-polar materials for the detection of concealed objects, while it is harmless to biological tissue and human body [6][7][8][9][10][11][12][13][14]. THz imaging can be divided into two types: active THz imaging and passive THz imaging.…”

Section: Introductionmentioning

confidence: 99%

Terahertz Imaging Progress at Capital Normal University

Zhao¹

2017

IJASS

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The progress on terahertz imaging at Capital Normal University in Beijing is presented. Our works on TerahertzImaging include the active and passive imaging. For the active terahertz imaging, the pulse and continue wave terahertz imaging are studied, respectively. The active terahertz pulse imaging is based on the terahertz time-domain spectroscopy (THz-TDS). A practical focus-plane imaging system is built up based on the THz-TDS with the probe-beam-expanded electro-optical sampling and an infrared CCD imaging. The active terahertz continuous wave imaging is based on a CO 2 -laser-pumped terahertz coherent source and an uncooled bolometer array of terahertz camera. The active terahertz polarization imaging and wave front imaging is developed. For the passive terahertz imaging, the low frequency of radiometers are used to detect the point-to-point beam-scanned terahertz signal by the optical focusing and scanning system so that the passive THz imaging is realized for the security inspection of human body. The related components and image processing methods are studied and used for the improvement of imaging speed and resolution. The research on THz imaging technology at Capital Normal University is opening up a potential application in the field of non-destructive testing and security inspection for the terahertz technology.

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Detection of colon cancer by continuous-wave terahertz polarization imaging technique

Cited by 110 publications

References 11 publications

Terahertz transmission vs reflection imaging and model-based characterization for excised breast carcinomas

Terahertz transmission vs reflection imaging and model-based characterization for excised breast carcinomas

Single-channel prototype terahertz endoscopic system

Terahertz Imaging Progress at Capital Normal University

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