Detection of Cognitive Impairment and Dementia Using the Animal Fluency Test: The DECIDE Study

Sebaldt, Rolf J.; Dalziel, William B.; Massoud, Fadi; Tanguay, André; Ward, Rick; Thabane, Lehana; Melnyk, Peter; Landry, Pierre-Alexandre; Lescrauwaet, Bénédicte

doi:10.1017/s0317167100008106

Cited by 32 publications

(16 citation statements)

References 31 publications

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“…The present study extended the abovementioned results of non-linear relationship to a simple yet widely used neuropsychological test for the detection of dementia: SF (more specifically, animal fluency) test. SF performance has been linked to medial temporal lobe (MTL) and anterior temporal cortex (Pelletier et al, 2017), and there is a large body of evidence supporting a diagnostic role of SF test in dementia (Sebaldt et al, 2009;Sutin et al, 2019), including AD (Henry et al, 2004). However, few studies have identified a significant relationship between cholesterol level and SF performance.…”

Section: Discussionmentioning

confidence: 99%

Low Cholesterol Level Linked to Reduced Semantic Fluency Performance and Reduced Gray Matter Volume in the Medial Temporal Lobe

Yang

Stanford

Jiang

2020

Front. Aging Neurosci.

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Hyperlipidemia has been proposed as a risk factor of dementia and cognitive decline. However, the findings of the relationship between cholesterol level and cognitive/brain function have been inconsistent. Here, using a well-controlled sample from the Parkinson's Progression Markers Initiative (PPMI), we investigated the probable nonlinear relationship between plasma total cholesterol (TC) level, gray matter volume (GMv), and cognitive performance in 117 non-demented subjects (mean age, 61.5 ± 8.9 years), including 67 Parkinson's disease (PD) patients and 50 demographically matched controls. A quadratic relationship between semantic fluency (SF) performance and TC levels was identified. Within the subjects with a desirable TC level (TC < 200 mg/dl), low TC (lTC) levels were associated with reduced SF performance, as well as reduced GMv in three medial temporal regions [including bilateral anterior hippocampus (HIP)]. In contrast, no significant relationship between TC and cognition performance/GMv was found in individuals with a high cholesterol level (i.e., TC ≥ 200 mg/dl). Further region of interest (ROI)-based analysis showed that individuals with TC levels ranging from 100 to 160 mg/dl had the lowest GMv in the medial temporal regions. These findings suggest that low-normal TC level may be associated with reduced cognitive function and brain atrophy in regions implicated in neurodegenerative diseases, adding to a growing body of literature supporting a probable non-linear relationship between cholesterol level and brain health. However, this finding needs to be verified with other large public cohort data that do not include PD patients.

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Section: Discussionmentioning

confidence: 99%

Low Cholesterol Level Linked to Reduced Semantic Fluency Performance and Reduced Gray Matter Volume in the Medial Temporal Lobe

Yang

Stanford

Jiang

2020

Front. Aging Neurosci.

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“…Patients who recalled less than 15 animals were deemed not appropriate for this study. The animal fluency test has a sensitivity of 88% and specificity of 96% in detecting cognitive impairment (10). Sampling for variation in gender, age, race, and the admitting hospital unit (i.e., cardiac, medicine, and surgery) was conducted.…”

Section: Methodsmentioning

confidence: 99%

Why older adults may decline offers of post-acute care services: A qualitative descriptive study

et al. 2017

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The most common post-acute care (PAC) services available to patients after hospital discharge include home care, skilled nursing facilities, nursing homes, inpatient rehabilitation, and hospice. Patients who need PAC and receive services have better outcomes, however almost one-third of those offered services decline. Little research exists on PAC decision-making and why patients may decline services. This qualitative descriptive study explored the responses of thirty older adults to the question: “Can you, from the patient point of view, tell me why someone would not want post hospital care?” Three themes emerged. Participants may decline due to 1) previous negative experiences with PAC, or 2) a preference to be home. Some participants stated, “I'd be there” and would not decline services. Participants also discussed 3) why other patients might decline PAC which included patients’ past experiences, fear of the unknown, and preferences. Clinical implications include assessing patients’ knowledge and experience before providing recommendations.

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“…[14][15][16] The study participants' cognitive function was assessed using the Mini-Mental State Examination (MMSE), Alzheimer's Disease Assessment Scale (ADAS) items 1-3 (measure of episodic memory delayed recall), A Quick Test of Cognitive Speed (AQT; measure of cognitive processing speed), and the 1-minute Animal Fluency test. [17][18][19][20] At each study visit, a thorough medical history was taken and the patients underwent extensive testing in both motor symptoms and cognition. The baseline data of the study participants in the present study have previously been described in Hall et al, 5 2012, where they were part of a larger cohort.…”

mentioning

confidence: 99%

CSF biomarkers and clinical progression of Parkinson disease

et al. 2015

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Detection of Cognitive Impairment and Dementia Using the Animal Fluency Test: The DECIDE Study

Cited by 32 publications

References 31 publications

Low Cholesterol Level Linked to Reduced Semantic Fluency Performance and Reduced Gray Matter Volume in the Medial Temporal Lobe

Low Cholesterol Level Linked to Reduced Semantic Fluency Performance and Reduced Gray Matter Volume in the Medial Temporal Lobe

Why older adults may decline offers of post-acute care services: A qualitative descriptive study

CSF biomarkers and clinical progression of Parkinson disease

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