Detection of citrinin in ochratoxin A-containing products by a new HPLC method

Meister, Ute

doi:10.1007/bf02940087

Cited by 9 publications

(2 citation statements)

References 4 publications

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“…Also, it is possible that sometimes at the time of processing there can appear conditions promoting equilibrium biosynthesis of toxins or a shift towards the accumulation of OTA. Therefore, in OTA-positive grain products with a larger ratio of the outer layers of the grain kernel low concentrations of CIT are detected rather frequently [14].…”

Section: Open Accessmentioning

confidence: 98%

Peculiarities of feed contamination with citrinin and ochratoxin A

Кононенко¹,

Буркин²

2013

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Occurrence of citrinin and ochratoxin A in different feed ingredients and compound feeds was screened by accredited methods based on the indirect competitive enzyme-linked immunosorbent assay. High frequency co-occurrence of both toxins was found in wheat grain and processed sunflower seeds. Citrinin levels exceeded those of ochratoxin A in the majority of co-contaminated feed samples, and the ratio of (1.1 - 10):1 proved to be the most frequent. A possible role of Aspergillus and Penicillium fungi in separate and simultaneous OTA and CIT occurrence in feeds is also discussed.

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Section: Open Accessmentioning

confidence: 98%

Peculiarities of feed contamination with citrinin and ochratoxin A

Кононенко¹,

Буркин²

2013

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“…It is also produced by several other species of Aspergillus, Penicillium, and Monascus (9). It has been implicated in porcine nephropathy (10) and has been found as a natural contaminant of corn, rice, wheat, rye, barley, and oats (11)(12)(13). Thus, citrinin is a potentially important mycotoxin that may be ingested by humans and animals and could cause a chronic disease (14).…”

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Genetic Variability of Citrinin-Producing Penicillium Citrinum Strains as Occupational Health Hazards in Northern Iran / Genska Varijabilnost Citrinin-Toksinogenih Sojeva Penicillium Citrinum Kao Izvor Opasnosti Za Zdravlje Profesionalno Izloženih Populacija U Sjevernom Iranu

Khosravi

Sheikhkarami

Shokri

et al. 2012

Archives of Industrial Hygiene and Toxicology

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We evaluated the ability of randomly amplifi ed polymorphic DNA (RAPD) to type citrinin-producing Penicillium citrinum (P. citrinum) strains recovered from the forest's air in northern Iran. A total of 12 P. citrinum strains (P1-P12) were characterised by citrinin production and random amplifi cation of polymorphic DNA (RAPD) technique. All the strains produced citrinin with levels ranging from 1.5 μg mL -1 to 39.6 μg mL -1 (average value: 12.68 μg mL -1 ). Of 11 primers tested, eight primers produced polymorphic amplifi cation patterns. These primers generated a total of 105 reproducible RAPD bands, averaging to 13.1 bands per primer. Dendrogram for each primer indicating the distance of the strains to each other was constructed. RAPD results showed that the collected strains constituted four different clusters. The fi rst cluster included two isolates (P1 and P3). The second cluster included seven isolates (P2, P4, P5, P6, P7, P8, and P10). The third and fourth clusters included one isolate (P9) and two isolates (P11 and P12), respectively. We concluded that RAPD analysis might be used in providing genotypic characters for toxigenic P. citrinum strains typing in epidemiological investigations and public health related risk assessment. Khorsavi AR, et al. CITRININ-PRODUCING PENICILLIUM CITRINUM AND HEALTH HAZARD KEY WORDS: airborne fungi, genetic variability, intraspecifi c differentiation, mycotoxin, random amplifi cation of polymorphic DNA (RAPD)

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Urinary biomarkers of ochratoxin A and citrinin exposure in two Bangladeshi cohorts: follow-up study on regional and seasonal influences

Ali

Blaszkewicz

Alim³

et al. 2015

Arch Toxicol

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Biomonitoring studies can provide valuable insights into human mycotoxin exposure, especially when food contaminant data are scarce or unavailable as in Bangladesh. First biomonitoring data in Bangladeshi adults indicated exposure to the nephrotoxic mycotoxins ochratoxin A (OTA) and citrinin (CIT). This led us to conduct a follow-up study with analysis of urinary biomarkers for both CIT and OTA to investigate regional and seasonal influences on mycotoxin exposure in two Bangladeshi cohorts. In total, 164 urines were collected (n = 69 in summer, n = 95 in winter) from residents of a rural and an urban area, among which there were 62 participants enrolled in both sampling periods. Most urines had detectable biomarker levels (OTA, CIT and its metabolite dihydrocitrinone, HO-CIT), with more or less pronounced differences with regard to season and region. In both cohorts, OTA was found at a mean level of 0.06 ± 0.10 ng/mL urine (range 0.01-0.55 ng/mL) in summer and a mean of 0.19 ± 0.38 ng/mL (range 0.01-1.75 ng/mL) in winter season. A season difference was significant in the rural cohort, but not in the urban cohort, and slightly higher mean OTA levels in the rural compared to the urban cohort were only observed in winter urines. CIT biomarkers showed more pronounced variations, with a CIT mean of 0.10 ± 0.17 ng/mL (range 0.02-1.22 ng/mL) and HO-CIT mean of 0.42 ± 0.98 ng/mL (range 0.02-5.39 ng/mL) in summer, and CIT mean of 0.59 ± 0.98 ng/mL (range 0.05-5.03 ng/mL) and HO-CIT mean of 3.18 ± 8.49 ng/mL (range 0.02-46.44 ng/mL) in winter urines of both cohorts. In both seasons, total CIT biomarker concentrations were significantly higher in the rural cohort than in the urban cohort. A provisional daily intake for CIT was calculated and exceeded a preliminary value set by EFSA (0.2 µg/kg/d) in 10 and 24 % of participants in summer and winter, respectively. No significant correlations were found between urinary biomarker levels and intake of certain types of food, except for a positive trend for higher rice consumption. Our results in the Bangladeshi population indicate frequent co-exposure to nephrotoxic mycotoxin food contaminants that vary by season and region.

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Detection of citrinin in ochratoxin A-containing products by a new HPLC method

Cited by 9 publications

References 4 publications

Peculiarities of feed contamination with citrinin and ochratoxin A

Peculiarities of feed contamination with citrinin and ochratoxin A

Genetic Variability of Citrinin-Producing Penicillium Citrinum Strains as Occupational Health Hazards in Northern Iran / Genska Varijabilnost Citrinin-Toksinogenih Sojeva Penicillium Citrinum Kao Izvor Opasnosti Za Zdravlje Profesionalno Izloženih Populacija U Sjevernom Iranu

Urinary biomarkers of ochratoxin A and citrinin exposure in two Bangladeshi cohorts: follow-up study on regional and seasonal influences

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