Detection of Circulating Tumour Cells and Survival of Patients with Non-Small Cell Lung Cancer

Chudasama, Dimple; Barr, James; Beeson, Julie; Emma, Beddow; McGonigle, Niall; Rice, Alexandra; Nicholson, Andrew G.; Anikin, Vladimir

doi:10.21873/anticanres.11302

Cited by 23 publications

(20 citation statements)

References 20 publications

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“…Moreover, the presence of some specific sequence variants in driver genes is currently under intensive investigation for cancer molecular diagnosis and pharmacogenomics including prediction of either susceptibility or resistance to the targeted therapy (5)(6)(7). In this context, introduction of innovative biotechnologies allows to identify, recover and analyze CTCs from the peripheral blood to perform the so-called "liquid biopsy" procedure (8)(9)(10)(11)(12)(13)(14)(15)(16).…”

Section: Abstract Background: Isolation and Genotyping Of Circulatinmentioning

confidence: 99%

Next-generation Sequencing (NGS) Analysis on Single Circulating Tumor Cells (CTCs) with No Need of Whole-genome Amplification (WGA)

Palmirotta

Lovero

Silvestris

et al. 2017

CGP

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Section: Abstract Background: Isolation and Genotyping Of Circulatinmentioning

confidence: 99%

Next-generation Sequencing (NGS) Analysis on Single Circulating Tumor Cells (CTCs) with No Need of Whole-genome Amplification (WGA)

Palmirotta

Lovero

Silvestris

et al. 2017

CGP

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“…It is important to prevent increased numbers of CTCs that may shed from the primary tumor due to surgical intervention for NSCLC. Interestingly, even for early stage lung cancer, CTCs can be detected in 60-80% in patients (18,19). Recently, Murlidhar et al (20) reported that PV had significantly not only higher number of CTCs, but also larger CTC clusters compared to pre-operative and intra-operative peripheral vein among early stage lung cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Wedge Resection of Tumor Before Lobectomy for Lung Cancer Could Be a No-touch Isolation Technique

Yasukawa

Sawabata

Kawaguchi

et al. 2020

In Vivo

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Background/Aim: Circulating tumor cells (CTCs) can be a surrogate biomarker of prospective prognosis. Surgical manipulation can promote the dissemination of CTCs. Prognosis improvement is expected with the no-touch isolation technique (NTIT), preventing surgical manipulation. The Wedge resection of the tumor site before lobectomy could prevent surgical manipulation during lobectomy for nonsmall cell lung cancer (NSCLC) and reduce the shedding of tumor cells, similar to a NTIT. This study aimed to evaluate the effect of wedge resection technique. Patients and Methods: A total of 624 resected NSCLC patients were retrospectively analyzed. Patients were divided in two groups: Wedge and Non-Wedge. Overall survival (OS) curves were plotted using the Kaplan-Meier method. Results: The 5-year OS rates were 89.9% and 84.0% in the Wedge and Non-Wedge groups, respectively (p=0.033). Conclusion: The OS in the Wedge group was significantly better than that in the Non-Wedge group. Wedge resection technique for NSCLC may be a NTIT.779 resection compared to non-wedge resection before lobectomy for NSCLC patients. The aim of this study was to evaluate the effect of wedge resection of the tumor site before lobectomy as a no-touch isolation technique. This is the first study to investigate the efficacy of wedge resection during lobectomy for NSCLC. Yasukawa et al: Effect of Wedge Resection of Tumor for NSCLC

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“…Several studies associate CTC number to OS and/or PFS of metastatic NSCLC patients (32,33,48,57), meanwhile others do not find these associations (70,71). Many small trials have also demonstrated the association between CTC count and therapy efficacy, comparing the count before and after therapy (38,(72)(73)(74), or during target therapy, in order to detect the onset of resistance mutations (50,54,62,66,75).…”

Section: The Long Road Towards Clinical Utilitymentioning

confidence: 99%

Critical issues in the clinical application of liquid biopsy in non-small cell lung cancer

et al. 2017

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Detection of Circulating Tumour Cells and Survival of Patients with Non-Small Cell Lung Cancer

Cited by 23 publications

References 20 publications

Next-generation Sequencing (NGS) Analysis on Single Circulating Tumor Cells (CTCs) with No Need of Whole-genome Amplification (WGA)

Next-generation Sequencing (NGS) Analysis on Single Circulating Tumor Cells (CTCs) with No Need of Whole-genome Amplification (WGA)

Wedge Resection of Tumor Before Lobectomy for Lung Cancer Could Be a No-touch Isolation Technique

Critical issues in the clinical application of liquid biopsy in non-small cell lung cancer

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