Detection of chronic obstructive pulmonary disease in community‐based annual lung cancer screening: <scp>C</scp>hiba Chronic Obstructive Pulmonary Disease <scp>L</scp>ung <scp>C</scp>ancer <scp>S</scp>creening <scp>S</scp>tudy <scp>G</scp>roup

Sekine, Yasuo; Fujisawa, Takehiko; Suzuki, Kiminori; Tsutatani, Shuko; Kubota, Kentaro; Ikegami, Hiroshi; Isobe, Yuji; Nakamura, Mitsugu; Takiguchi, Yuichi

doi:10.1111/resp.12179

Cited by 20 publications

(11 citation statements)

References 24 publications

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“…Each image was classified as normal (score 0), ≤ 5 % affected (score 0.5), ≤25 % affected (score 1), ≤ 50 % affected (score 2), ≤75 % affected (score 3) or >75 % affected (score 4). The average score of six images was considered as a representative value of the severity of emphysema in each patient, and the patients were further categorized into three groups as previously suggested [16]: no/mild emphysema (average severity score < 1); moderate emphysema (1 ≤ average severity score < 2.5); and severe emphysema (average severity score ≥ 2.5).…”

Section: Methodsmentioning

confidence: 99%

The regional association between bronchiectasis and lung cancer in chest CT

et al. 2016

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BackgroundLimited studies have examined the association between lung cancer and bronchiectasis (BE). This study evaluated the regional association between BE and lung cancer by analyzing the lobar location of lung cancer in patients with underlying BE.MethodsThis clustered multi-level study enrolled patients who had underlying BE and were newly diagnosed with lung cancer between January 1, 2010 and May 30, 2013 in two referral hospitals in South Korea. By analyzing the presence of lung cancer and underlying BE as event variables at the level of lung lobes on chest computed tomography (CT), we evaluated the association of BE and lung cancer by the locations of the diseases.ResultsEighty-one patients with BE and combined lung cancer were enrolled. Within 486 lung lobes of the patients, combined BE and lung cancer in the same lobe was found in 11 lobes (2.3 %). Using the general estimating equation assuming BE as a risk factor of lung cancer, the results indicated that the prevalence of lung cancer was significantly lower in the lobes with pre-existing BE (β = −1.09, p-value = 0.001).ConclusionsRegionally, pre-existing BE was associated with a lower risk of the occurrence of lung cancer in the same lobe.Electronic supplementary materialThe online version of this article (doi:10.1186/s12890-016-0311-4) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

The regional association between bronchiectasis and lung cancer in chest CT

et al. 2016

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“…Based on a quick questionnaire that collected information about age, smoking history, and chronic respiratory symptoms, they identified 878 individuals fulfilling the defined criteria out of 89100 participants (1.0%). A total of 567 of the 878 participants (64.6%) underwent further evaluation consisting of CT and spirometry, resulting in the detection of COPD in 161 participants, with 38.5% of them requiring COPD treatment [60] . Although the data regarding lung cancer detection are not yet available because the trial is still ongoing, this strategy for identifying a high-risk population based on suspected COPD could be an alternative to identification strategies based on age and smoking history.…”

Section: Future Directionsmentioning

confidence: 99%

Chronic obstructive pulmonary disease as a risk factor for lung cancer

Takiguchi

Sekine

Iwasawa

et al. 2014

WJCO

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The association between chronic obstructive pulmonary disease (COPD) and lung cancer has long been a subject of intense debate. The high prevalence of COPD in elderly smokers inevitably strengthens their coincidence. In addition to this contingent coincidence, recent studies have revealed a close association between the two diseases that is independent of the smoking history; that is, the existence of COPD is an independent risk factor for the development of lung cancer. Molecular-based evidence has been accumulating as a result of the efforts to explain the underlying mechanisms of this association. These mechanisms may include the following: the retention of airborne carcinogens followed by the activation of oncogenes and the suppression of tumor suppressor genes; the complex molecular mechanism associated with chronic inflammation in the distal airways of patients with COPD; the possible involvement of putative distal airway stem cells; and genetic factors that are common to both COPD and lung cancer. The existence of COPD in patients with lung cancer may potentially affect the process of diagnosis, surgical resection, radiotherapy, chemotherapy, and end-of-life care. The comprehensive management of COPD is extremely important for the appropriate treatment of lung cancer. Surgical resections with the aid of early interventions for COPD are often possible, even for patients with mild-to-moderate COPD. New challenges, such as lung cancer CT screening for individuals at high risk, are now in the process of being implemented. Evaluating the risk of lung cancer in patients with COPD may be warranted in community-based lung cancer screening.

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“…The present study is the second to describe the utilization of regional mass screening for lung cancer to detect COPD 16. Of course, screening programs are clearly targeted at specific disease entities.…”

Section: Discussionmentioning

confidence: 97%

Surveillance of chronic obstructive pulmonary disease in high-risk individuals by using regional lung cancer mass screening

Sekine¹,

Yanagibori²,

Suzuki³

et al. 2014

COPD

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Background and objectivePatients with chronic obstructive pulmonary disease (COPD) are at risk for lung cancer; the diseases have common etiologies, including cigarette smoking. We aimed to clarify the effectiveness of COPD detection using a regional mass-screening program for lung cancer.Materials and methodsA total of 7,067 residents of Togane, Chiba, Japan received lung cancer screening between May and July, 2011. We defined four groups of possible COPD candidates: group A (n=358), positive smoking history, positive chronic respiratory symptoms; group B (n=766), positive smoking history, positive lifestyle-related disease; group C (n=75), passive smoking history, positive chronic respiratory symptoms; and group D (n=301), passive smoking history, positive lifestyle-related disease. Candidates underwent on-site pulmonary function testing (PFT).ResultsThe criteria for COPD candidates were fulfilled in 1,686 of 7,067 individuals (23.9%); 1,500 participants underwent PFT (89%), and 171 (11.4%) were diagnosed with COPD. The overall COPD detection rate was 2.4%. The frequency of COPD was significantly higher in groups A and B than in groups C and D (P=0.048); however, the distribution of COPD grades was similar among the groups (P=0.372). Multiple logistic regression analysis identified male sex, age 60 years or greater, and positive smoking history as risk factors for COPD.ConclusionCOPD screening using a community-based lung cancer-screening program may be effective for disease detection. Individuals who are 60 years of age or older with a positive smoking history should undergo PFT to detect COPD.

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Detection of chronic obstructive pulmonary disease in community‐based annual lung cancer screening: Chiba Chronic Obstructive Pulmonary Disease Lung Cancer Screening Study Group

Abstract: COPD screening added to a community-based lung cancer screening programme may be effective in the detection of patients with COPD.

Cited by 20 publications

References 24 publications

The regional association between bronchiectasis and lung cancer in chest CT

The regional association between bronchiectasis and lung cancer in chest CT

Chronic obstructive pulmonary disease as a risk factor for lung cancer

Surveillance of chronic obstructive pulmonary disease in high-risk individuals by using regional lung cancer mass screening

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