Detection of chronic lymphocytic leukemia cell surface markers using surface enhanced Raman scattering gold nanoparticles

Nguyen, Collin T.; Nguyen, James; Rutledge, Steve; Zhang, Janing; Wang, Chen; Walker, Gilbert C.

doi:10.1016/j.canlet.2009.11.011

Cited by 71 publications

(57 citation statements)

References 26 publications

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“…Raman signals were not disrupted by pathology stains such as eosin, hematoxylin, and Giemsa, indicating advantages over fluorescence methods for multiplex pathology diagnosis. 130 An interesting and novel type of stand-alone cellular SERS tag called a nanocoral was reported. 185 As shown in Figure 8, half of the nanocoral's surface was coated with highly roughened gold to increase its reporter adsorption capacity and create a high density of SERS hot spots, and the blank polystyrene hemisphere could be functionalized with targeting moieties to specific cells.…”

Section: Pathogen Detectionmentioning

confidence: 99%

“…144,145 Stable covalent bonds can also be formed by coating the tags with ortho-pyridyldisulfide-polyethylene glycol-N-succinimidyl propionate (OPSS-PEG-NHS). 100,130 The mercapto groups can bind to the metal NP's surface, and N-succinimidyl can form stable amide bonds with amines in various biomolecules. Similarly, with the aid of coupling reagents such as 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimides (NHS), carboxylic acid groups on the surface-coating molecules (such as BSA) are activated for the reaction with the amine groups in the antibody.…”

Section: Attachment Of Targeting Moleculesmentioning

confidence: 99%

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SERS Tags: Novel Optical Nanoprobes for Bioanalysis

2012

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Section: Pathogen Detectionmentioning

confidence: 99%

Section: Attachment Of Targeting Moleculesmentioning

confidence: 99%

SERS Tags: Novel Optical Nanoprobes for Bioanalysis

2012

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“…[29][30][31] This unique and highly desirable feature will simplify measurement and reduce the cost of SERS/SERRS signifi cantly while maintaining very high sensing performance. In addition, this novel substrate may open new markets to Raman spectroscopic technologies for medical diagnostics, [ 57,58 ] food safety, [ 59 ] national defense, [ 60 ] environmental monitoring, [ 61 ] art preservation, [ 62 ] anticounterfeit security, [ 63 ] rapid screening, [ 64 ] etc. Admittedly, the Raman fi lter for a particular excitation wavelength has to be changed for a different excitation wavelength.…”

Section: Resultsmentioning

confidence: 99%

Ultrabroadband Metasurface for Efficient Light Trapping and Localization: A Universal Surface‐Enhanced Raman Spectroscopy Substrate for “All” Excitation Wavelengths

Zhang

Liu

et al. 2015

Adv Materials Inter

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nanoporous lithography methods, [18][19][20][21] etc. However, these techniques are still expensive and complicated for the fabrication of high quality SERS substrates over large areas, thus resulting in high prices for commercial SERS substrates. Furthermore, most commercial SERS substrates can only work for individual excitation wavelengths, i.e., one particular product works at one or two excitation wavelengths only. [22][23][24][25][26][27][28] When one wants to identify anonymous trace molecules or mixed samples, multiple excitation wavelengths will be required. [29][30][31] In this case, different substrates have to be used for different wavelength excitation, which consumes more biological/chemical materials, substrates, and measurement time. This is an obvious disadvantage for conventional SERS substrates. On the contrary, the SERS EF is proportional to the product of the fi eld intensity enhancements at both excitation and Raman scattering wavelengths. It was predicted that the maximum SERS enhancement can be achieved when localized surface plasmon resonance is located between the excitation and Raman scattering wavelengths. [ 32 ] To realize higher EF, double-resonance SERS substrates were proposed to realize strong enhancements for excitation and Raman scattered signals simultaneously using expensive e-beam lithography processes. [ 23 ] Due to the narrowband absorption spectra for both resonant bands, the enhanced SERS signal is still limited within narrow spectral regions. To address this problem, broadband resonant nanostructures are highly desired. For instance, a relatively broadband 1D metal-dielectric-metal metasurface (i.e., ≈70% optical absorption from 420 to 550 nm) was fabricated using e-beam lithography to realize uniform enhancement for SERS sensing. [ 24 ] However, the top-down lithography technique imposed a signifi cant fabrication cost barrier for large-scale practical applications. In addition, 1D grating structures are polarization dependent which can only work for given polarization states (usually transverse magnetic polarization). To overcome these limitations, here we report an ultrabroadband super absorbing metasurface substrate that can enhance the SERS signal for excitation wavelengths in a broad spectral region using lithography-free processes. [ 33 ] Most frequently used excitation wavelengths for SERS (e.g., from 450 to 1100 nm [23][24][25][26][27][28]34 ] are all covered due to the broadband light trapping and fi eld concentration within deep subwavelength Most reported surface-enhanced Raman spectroscopy (SERS) substrates can work for individual excitation wavelengths only. Therefore, different substrates have to be used for different excitation wavelengths, which consumes more biological/chemical materials, substrates, and measurement time. Here, an ultrabroadband super absorbing metasurface that can work as a universal substrate for low cost and high performance SERS sensing is reported. Due to broadband light trapping and localized fi eld enhancement, this structure can...

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“…They compared this selective binding in MDA-MB as an HER2-negative breast cancer cell line. Due to the formation of aggregates in the presence of SKBR3 cells, it formed several hot spots, which provided significant enhancement of Raman signal intensity from SWCNTs by three orders of magnitude through electromagnetic field enhancements [39,44]. SERS nano-tags with metallic NPs in the form of nano rods, hollow nanostructures, and nano stars because of having an active hot spot could give out higher sensitivity that is useful for in vivo applications.…”

Section: Nanoparticles and Raman Techniquesmentioning

confidence: 99%

Application of nanoparticles in cancer detection by Raman scattering based techniques

Ravanshad

Zadeh

Amani

et al. 2017

Nano Reviews & Experiments

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In vitro detection technique Raman spectroscopy (Rs), in one number times another Rs based expert ways of art and so on, are useful instruments for cancer discovery. top gave greater value to Raman spectroscopy sers is a relatively new careful way for in vitro and in vivo discovery that takes away bad points of simple Raman spectroscopy (Rs). Raman spectroscopy (RS) and in particular, multiple RS-based techniques are useful for cancer detection. Surface enhanced Raman spectroscopy (SERS) is a relatively new method for both in vitro and in vivo detection, which eliminates the drawbacks of simple RS. Using nanoparticles has elevated the sensitivity and specificity of SERS. SERS has the potential to increase sensitivity, specificity and spatial resolution in cancer detection, especially in cooperation with other diagnostic imaging tools such as magnetic resonance imaging (MRI) and PET-scan polyethylene terephthalate. Developing a hand held instrument for detecting cancer or other illnesses may also be feasible by using SERS. Frequently, novel nanoparticles are used in SERS. With a focus on nanoparticle utilization, we review the benefits of RS in cancer detection and related biomarkers. With a focus on nanoparticles utilizations, the benefits of RS in cancer detection and related biomarkers were reviewed. In addition, Raman applications to detect some of prevalent were discussed. Also more investigated cancers such as breast and colorectal cancer, multiple nanostructures and their possible special biomarkers, especially as SERS nano-tag have been reviewed. The main purpose of this article is introducing of most popular nanotechnological approaches in cancer detection by using Raman techniques. Moreover, have been caught up on detection and reviewed some of the most prevalent and also more investigated cancers such as breast, colorectal cancer, multiple intriguing nanostructures, especially as SERS nano-tag, special cancer biomarkers and related approaches. The main purpose of this article is to introduce the most popular nanotechnological approaches in cancer detection by using Raman techniques.

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Detection of chronic lymphocytic leukemia cell surface markers using surface enhanced Raman scattering gold nanoparticles

Cited by 71 publications

References 26 publications

SERS Tags: Novel Optical Nanoprobes for Bioanalysis

SERS Tags: Novel Optical Nanoprobes for Bioanalysis

Ultrabroadband Metasurface for Efficient Light Trapping and Localization: A Universal Surface‐Enhanced Raman Spectroscopy Substrate for “All” Excitation Wavelengths

Application of nanoparticles in cancer detection by Raman scattering based techniques

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