Detection of Chemical Warfare Agents With Chemical Sensors

Recent advances in fluorescent and colorimetric chemosensors for the detection of chemical warfare agents: a legacy of the 21st century

“…Similarly, Leblanc's group placed two coumarin moieties in a single crown ether chemosensor (116) and observed a slight blue shift (7 nm) that was attributed to the destabilization of the excited state of the fluorophore by the analyte. 248 The fluorescence spectroscopic results indicated two emission bands at 420 nm and 550 nm.…”

“…Therefore, a chemosensor can be defined as a molecule that interacts reversibly with an analyte and transforms chemical information into analytically useful and measurable signals. [114][115][116] The measurable signal is the result of two different processes occurring during host molecule/ receptor and analyte/guest interaction i.e., molecular recognition and signal transduction. 110 The molecular recognition is based on size, shape, geometry complementarity, and the presence of specific physical and chemical interactions.…”

“…240 Similarly, STX inhibits PeT when bisguanidinium ions bind to crown ethers via ion-dipole interactions. Molecular probes (110)(111)(112)(113)(114)(115)(116) based on several fluorophores (anthracene, coumarin, acridine, and aza-BODIPY) and crown ethers were designed and exploited for the detection of STX (Fig. 87).…”