Detection of cervical metastases with <sup>11</sup>C‐tyrosine pet in patients with squamous cell carcinoma of the oral cavity or oropharynx: A comparison with <sup>18</sup>F‐FDG PET

Krabbe, Christiaan A.; Werff-Regelink, G. van der; Pruim, Jan; Roodenburg, Jan

doi:10.1002/hed.21192

Cited by 13 publications

(4 citation statements)

References 21 publications

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“…The main problem with early 18 F‐FDG PET/CT evaluations in this context is the deficient specificity of the method due to tracer uptake in inflammatory cells. Use of amino‐acid tracers has been proposed to circumvent this problem but the intense uptake of these tracers in the salivary glands might be a new source of false‐positive findings 31, 32.…”

Section: Discussionmentioning

confidence: 99%

¹⁸F‐FDG PET/CT and MRI in the follow‐up of head and neck squamous cell carcinoma

Ghanooni

Delpierre

Magremanne

et al. 2011

Contrast Media & Molecular

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We evaluated the diagnostic performance of (18)F-FDG PET/CT and MRI for the assessment of head and neck squamous cell carcinoma (HNSCC) relapse. Since early treatment might prevent inoperable relapse, we also evaluated THE performance of early unenhanced (18)F-FDG PET/CT in residual tumor detection. The study was prospectively performed on 32 patients who underwent (18)F-FDG PET/CT and MRI before treatment and at 4 and 12 months after treatment. (18)F-FDG PET/CT was also performed 2 weeks after the end of radiotherapy. Histopathology or a minimum of 18 months follow-up were used as gold standard. Before treatment (18)F-FDG PET/CT and MRI detected all primary tumors except for two limited vocal fold lesions (sensitivity 94%). MRI was more sensitive than (18)F-FDG PET/CT for the detection of local extension sites (sensitivity 75 vs 58%), but at the cost of a higher rate of false positive results (positive predictive value 74 vs 86%). For relapse detection at 4 months, sensitivity was significantly higher for (18)F-FDG PET/CT (92%) than for MRI (70%), but the diagnostic performances were not significantly different at 12 months. For the detection of residual malignant tissue 2 weeks post-radiotherapy, sensitivity and specificity of (18)F-FDG PET/CT were respectively 86 and 85% (SUV cut-off value 5.8). (18)F-FDG PET/CT is effective in the differentiation between residual tumor and radiation-induced changes, as early as 2 weeks after treatment of a primary HNSCC. For follow-up, performance of (18)F-FDG PET/CT and MRI are similar except for a higher sensitivity of (18)F-FDG PET/CT at 4 months.

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Section: Discussionmentioning

confidence: 99%

¹⁸F‐FDG PET/CT and MRI in the follow‐up of head and neck squamous cell carcinoma

Ghanooni

Delpierre

Magremanne

et al. 2011

Contrast Media & Molecular

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“…PET/MRI has a higher sensitivity in assessing soft tissue infiltration in comparison to MRI. 18 F-FAMT can be used to assess bone marrow involvement [13,40–42]. …”

Section: Imaging Methods In Oral Cancermentioning

confidence: 99%

Contemporary Diagnostic Imaging of Oral Squamous Cell Carcinoma – A Review of Literature

et al. 2018

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SummaryOral squamous cell carcinoma (OSCC) is the most common cancer of the oral cavity and constitutes 95% of all cancers of this area. Men are affected twice as commonly as women, primarily if they are over 50 years of age. Forty percent of the lesions are localized in the tongue and 30% in the floor of the oral cavity. OSCC often affects upper and lower gingiva, buccal mucous membrane, the retromolar triangle and the palate. The prognosis is poor and the five-year survival rate ranges from 20% (OSCC in the floor of the mouth) to 60% (OSCC in the alveolar part of the mandible). Treatment is difficult, because of the localization and the invasiveness of the available methods. The diagnosis is made based on a histopathological examination of a biopsy sample.The low detection rate of early oral SCC is a considerable clinical issue. Although the oral cavity can be easily examined, in the majority of cases oral SCC is diagnosed in its late stages. It is difficult to diagnose metastases in local lymph nodes and distant organs, which is important for planning the scope of resection and further treatment, graft implantation, and differentiation between reactive and metastatic lymph nodes as well as between disease recurrence and scars or adverse reactions after surgery or radiation therapy.Imaging studies are performed as part of the routine work-up in oral SCC. However, it is difficult to interpret the results at the early stages of the disease. The following imaging methods are used – dental radiographs, panoramic radiographs, magnetic resonance imaging with diffusion-weighted and dynamic sequences, perfusion computed tomography, cone beam computed tomography, single-photon emission computed tomography, hybrid methods (PET/CT, PET/MRI, SPECT/CT) and ultrasound. Some important clinical problems can be resolved with the use of novel modalities such as MRI with ADC sequences and PET.The aim of this article is to describe oral squamous cell carcinoma as it appears in different imaging methods considering both their advantages and limitations.

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“…The incorporation of tyrosine explains this into secretory proteins synthesized in salivary glands. 239,377,378 However, a later study to detect cervical metastases revealed the unsuitability of [ 11 C]tyrosine due to the increased bilateral uptake in the salivary glands, which impaired the visualization of metastases located within this area. 378 Therefore, [ 11 C]tyrosine is probably unsuitable for imaging the liver, pancreas, or salivary glands due to high accumulation in these organs.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Studies performed in patients with prolactinomas, a benign pituitary gland tumor that produces an excessive amount of the hormone prolactin, assessed the effect of bromocriptine treatment, showing the potential use of this radiotracer for investigating the salivary glands. The incorporation of tyrosine explains this into secretory proteins synthesized in salivary glands. ,, However, a later study to detect cervical metastases revealed the unsuitability of [ 11 C]tyrosine due to the increased bilateral uptake in the salivary glands, which impaired the visualization of metastases located within this area . Therefore, [ 11 C]tyrosine is probably unsuitable for imaging the liver, pancreas, or salivary glands due to high accumulation in these organs.…”

Section: Amino Acidsmentioning

confidence: 99%

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

et al. 2022

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The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET tracer development using the short-lived radionuclides carbon-11. In the last few decades, methodological improvements and fully automated modules have allowed the development of carbon-11 tracers for clinical use. Radiolabeling natural compounds with carbon-11 by substituting one of the backbone carbons with the radionuclide has provided important information on the biochemistry of the authentic compounds and increased the understanding of their in vivo behavior in healthy and diseased states. The number of endogenous and natural compounds essential for human life is staggering, ranging from simple alcohols to vitamins and peptides. This review collates all the carbon-11 radiolabeled endogenous and natural exogenous compounds synthesised to date, including essential information on their radiochemistry methodologies and preclinical and clinical studies in healthy subjects.

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Detection of cervical metastases with ¹¹C‐tyrosine pet in patients with squamous cell carcinoma of the oral cavity or oropharynx: A comparison with ¹⁸F‐FDG PET

Abstract: Because of bilateral accumulation of (11)C-TYR in salivary glands, (11)C-TYR PET is not suitable to replace (18)F-FDG PET in staging SCC of oral cavity and oropharynx.

Cited by 13 publications

References 21 publications

¹⁸F‐FDG PET/CT and MRI in the follow‐up of head and neck squamous cell carcinoma

¹⁸F‐FDG PET/CT and MRI in the follow‐up of head and neck squamous cell carcinoma

Contemporary Diagnostic Imaging of Oral Squamous Cell Carcinoma – A Review of Literature

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

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Detection of cervical metastases with 11C‐tyrosine pet in patients with squamous cell carcinoma of the oral cavity or oropharynx: A comparison with 18F‐FDG PET

Abstract: Because of bilateral accumulation of (11)C-TYR in salivary glands, (11)C-TYR PET is not suitable to replace (18)F-FDG PET in staging SCC of oral cavity and oropharynx.

Cited by 13 publications

References 21 publications

18F‐FDG PET/CT and MRI in the follow‐up of head and neck squamous cell carcinoma

18F‐FDG PET/CT and MRI in the follow‐up of head and neck squamous cell carcinoma

Contemporary Diagnostic Imaging of Oral Squamous Cell Carcinoma – A Review of Literature

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

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Product

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About

Detection of cervical metastases with ¹¹C‐tyrosine pet in patients with squamous cell carcinoma of the oral cavity or oropharynx: A comparison with ¹⁸F‐FDG PET

¹⁸F‐FDG PET/CT and MRI in the follow‐up of head and neck squamous cell carcinoma

¹⁸F‐FDG PET/CT and MRI in the follow‐up of head and neck squamous cell carcinoma