Detection of carcinoembryonic antigen mRNA in peritoneal lavage by the transcription-reverse transcription concerted method indicates poor prognosis in patients with stage II and III colon cancer

Murono, Koji; Kazama, Shinsuke; Yamaguchi, Hironori; Kawai, Kazushige; Ishihara, Soichiro; Sunami, Eiji; Kitayama, Joji; Satoh, Yumiko; Kurihara, M.; Yatomi, Yutaka; Watanabe, Toshiaki

doi:10.1016/j.surg.2014.09.015

Cited by 9 publications

(7 citation statements)

References 38 publications

(28 reference statements)

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“…Three studies [36,39,40], including data on 439 patients (24 metachronous pmCRC, 415 non-pmCRC) regarding peritoneal carcinoembryonic antigen (CEA) mRNA, were included in the metaanalysis. The CEA mRNA in the peritoneal lavage was measured using the transcription-reverse transcription concerted method.…”

Section: Peritonealcarcinoembryonicantigenmrnamentioning

confidence: 99%

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Risk factors for developing peritoneal metastases after curative surgery for colorectal cancer: A systematic review and meta‐analysis

et al. 2021

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Aim: Proactive detection and treatment strategies have achieved encouraging survival outcomes for patients with early peritoneal metastases (PM), but these costly and invasive approaches can only be applied to selected high-risk patients. This meta-analysis aimed to identify the risk factors for metachronous PM after curative surgery for colorectal cancer (CRC). Method:The study was registered at PROSPERO (CRD42020219187). Databases were searched for studies comparing clinical and histopathological characteristics between patients with metachronous peritoneal metastases from colorectal cancer (pmCRC) and patients without (non-pmCRC).Results:Thirtysix studies were included. Metachronous PM were positively associated

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Section: Peritonealcarcinoembryonicantigenmrnamentioning

confidence: 99%

“…(a) Peritoneal cytology (n = 3330; P < 0.001; Cochran Q 22.7, 11 df, P = 0.019; I 2 = 51.5) [27-38]. (b) Peritoneal CEA mRNA (n = 439; P < 0.001; Cochran Q 1.4, 2 df, P = 0.480; I 2 = 0)[36,39,40]…”

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confidence: 99%

Risk factors for developing peritoneal metastases after curative surgery for colorectal cancer: A systematic review and meta‐analysis

et al. 2021

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“…A r t i c l e [26][27][28][29][30]. Our findings may be due to persistence of micrometastases during nCRT and continued production of CEA as a result.…”

Section: A C C E P T E Dmentioning

confidence: 63%

Prognostic impact of CEA levels in rectal cancer patients who had received neoadjuvant chemoradiotherapy

Joo

Lim

2021

Ann Coloproctol

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Carcinoembryonic antigen (CEA) is a useful marker for rectal cancer. The aim of this study was to investigate the prognostic impact of CEA level according to neoadjuvant chemoradiotherapy (nCRT) in rectal cancer patients who underwent radical surgery.Methods: A total of 245 patients with rectal cancer who underwent radical surgery were retrospectively evaluated. Serum CEA level was measured preoperatively and postoperatively. We compared survival outcomes based on CEA level before and after surgery according to nCRT.Results: Of the 245 patients, elevation of CEA level was observed preoperatively in 79 and postoperatively in 30, respectively. Eighty-seven (35.5%) patients received nCRT, and elevated CEA level was a significant prognostic factor both before and after surgery. In patients who had not received nCRT, an elevated CEA level was a significant prognostic factor before surgery but was not significant after surgery. In a multivariate analysis for prognostic factors, elevation of preoperative CEA level was an independent prognostic factor of disease-free survival (DFS) regardless of nCRT.Postoperative CEA level was an independent prognostic factor of DFS in patients who had received nCRT but was not a factor in patients who had not received nCRT. Conclusion:Serum CEA level was an independent prognostic factor both preoperatively and postoperatively in rectal cancer patients who had received nCRT.

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“…The level of CEA was found to be an independent risk factor for peritoneal recurrence in DCC patients. It is known that the presence of CEA mRNA detected in peritoneal lavage fluid at laparotomy is associated with not only an increased incidence of peritoneal recurrence but also poor survival in patients with pancreatic cancer and colon cancer . Furthermore, an elevated level of CEA is associated with poor prognosis in patients with cholangiocarcinoma .…”

Section: Discussionmentioning

confidence: 99%

Impact of preoperative percutaneous transhepatic biliary drainage on post‐operative survival in patients with distal cholangiocarcinoma

Mori

Aoki

Park

et al. 2019

ANZ Journal of Surgery

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Background: The aim of this study was to investigate the long-term impact of the type of preoperative biliary drainage used for patients undergoing pancreatoduodenectomy for distal cholangiocarcinoma (DCC). Methods: A total of 84 patients with DCC who underwent preoperative biliary drainage between June 2000 and December 2016 were divided into groups for whom percutaneous transhepatic biliary drainage (PTBD) (n = 24) or endoscopic biliary drainage (EBD) (n = 60) was used. Results: The 5-year overall survival in the PTBD group was significantly worse than that in the EBD group (16.7% versus 52.3%, P = 0.007). After propensity score matching (22 patients in each group), the 5-year overall survival in the PTBD group was still worse than that in the EBD group (13.6% versus 61.2%, P = 0.003). Multivariate analysis revealed that PTBD was independent risk factor for both poor survival (P = 0.028) and peritoneal recurrence (P = 0.018). The incidence of multiple sites at initial recurrence tended to be higher in the PTBD group than in the EBD group (P = 0.080). Conclusions: PTBD should not be performed for patients undergoing pancreatoduodenectomy for DCC, except when EBD is contraindicated, as PTBD is significantly associated with shorter survival and peritoneal recurrence.

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Detection of carcinoembryonic antigen mRNA in peritoneal lavage by the transcription-reverse transcription concerted method indicates poor prognosis in patients with stage II and III colon cancer

Cited by 9 publications

References 38 publications

Risk factors for developing peritoneal metastases after curative surgery for colorectal cancer: A systematic review and meta‐analysis

Risk factors for developing peritoneal metastases after curative surgery for colorectal cancer: A systematic review and meta‐analysis

Prognostic impact of CEA levels in rectal cancer patients who had received neoadjuvant chemoradiotherapy

Impact of preoperative percutaneous transhepatic biliary drainage on post‐operative survival in patients with distal cholangiocarcinoma

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