Detection of Carcinoembryonic Antigen Messenger RNA-Expressing Cells in Peripheral Blood 7 Days After Curative Surgery is a Novel Prognostic Factor in Colorectal Cancer

Sadahiro, Sotaro; Suzuki, Toshiyuki; Maeda, Yuji; Yurimoto, Satoshi; Yasuda, Seiei; Makuuchi, Hiroyasu; Kamijo, Akemi; Murayama, Chieko

doi:10.1245/s10434-006-9289-0

Cited by 39 publications

(37 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Seven of the included studies used a single marker to detect CTCs, with the chosen marker being CEA mRNA (n ¼ 5), cytokeratin-20 (CK20), or guanylyl cyclase (GCC) (Taniguchi et al, 2000;Ito et al, 2002;Bessa et al, 2003;Chen et al, 2004;Sadahiro et al, 2005Sadahiro et al, , 2007Koch et al, 2006). The other studies used multiple markers, with an overall CTC-positive result usually being determined by detection of more than one marker.…”

Section: Ctc Detection Methodsmentioning

confidence: 99%

“…The 14 studies included here comprised 1841 patients in total, with the median number of patients in each study being 99.5 (range 42 -438) (Taniguchi et al, 2000;Yamaguchi et al, 2000;Ito et al, 2002;Bessa et al, 2003;Chen et al, 2004;Sadahiro et al, 2005Sadahiro et al, , 2007Katsumata et al, 2006;Koch et al, 2006;Lloyd et al, 2006;Allen-Mersh et al, 2007;Uen et al, 2007Uen et al, , 2008Wang et al, 2007).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Of the 14 studies included, eight undertook blood sampling perioperatively (Taniguchi et al, 2000;Yamaguchi et al, 2000;Ito et al, 2002;Chen et al, 2004;Sadahiro et al, 2005;Katsumata et al, 2006;Koch et al, 2006;Lloyd et al, 2006), four undertook sampling approximately 24 h after resection (Bessa et al, 2003;Koch et al, 2006;Lloyd et al, 2006;Allen-Mersh et al, 2007), and six undertook sampling between 24 h and 14 days after resection (Chen et al, 2004; Allen-Mersh et al, 2007;Sadahiro et al, 2007;Uen et al, 2007Uen et al, , 2008Wang et al, 2007).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Seven investigated the role of CTC in patients with stage-I to stage-III disease undergoing potentially curative surgery (Ito et al, 2002;Bessa et al, 2003;Sadahiro et al, 2005Sadahiro et al, , 2007Allen-Mersh et al, 2007;Wang et al, 2007;Uen et al, 2008); three studied CTC in patients with early CRC (of which two investigated stage-II disease alone (Koch et al, 2006;Uen et al, 2007) and one investigated stage-I and stage-II disease (Lloyd et al, 2006)); and four papers included patients with stage-I to stage-IV disease (Taniguchi et al, 2000;Yamaguchi et al, 2000;Chen et al, 2004;Katsumata et al, 2006).…”

Section: Tumour Stagementioning

confidence: 99%

“…Of the 14 studies included in our analysis, 10 involved sampling of peripheral blood only (Ito et al, 2002;Bessa et al, 2003;Chen et al, 2004;Katsumata et al, 2006;Lloyd et al, 2006;Allen-Mersh et al, 2007;Sadahiro et al, 2007;Uen et al, 2007Uen et al, , 2008Wang et al, 2007); 1 used peripheral and portal blood samples (Sadahiro et al, 2005); 1 used peripheral and mesenteric samples (Yamaguchi et al, 2000); 1 used peripheral, portal and mesenteric samples (Taniguchi et al, 2000); and 1 used samples of central venous blood (Koch et al, 2006).…”

Section: Blood Sampling Sitementioning

confidence: 99%

See 4 more Smart Citations

Prognostic significance of circulating tumour cells following surgical resection of colorectal cancers: a systematic review

et al. 2010

View full text Add to dashboard Cite

Background: The role of adjuvant chemotherapy after resection of colorectal cancers (CRCs) is well understood for patients with stage-I or stage-III disease. Its efficacy for those with stage-II disease remains much less clear. Many investigators have sought to identify prognostic markers that might clarify which patients have the highest risk of recurrence and would, therefore, be most likely to benefit from chemotherapy. This systematic review examines evidence for the use of peripherally sampled, circulating tumour cells (CTCs) as such a prognostic marker. Methods: A comprehensive literature search was used to identify studies reporting on the significance of CTCs in the postoperative blood of CRC patients. Results: Fourteen studies satisfied the inclusion criteria. Six of the nine studies that took blood samples 24 h or more postoperatively found detection of postoperative CTCs to be an independent predictor of cancer recurrence. Conclusion: The presence of CTCs in peripheral blood at least 24 h after resection of CRCs is an independent prognostic marker of recurrence. Further studies are needed to clarify the optimal time point for blood sampling and determine the benefit of chemotherapy in CTC-positive patients with stage-II disease.

show abstract

Section: Ctc Detection Methodsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Tumour Stagementioning

confidence: 99%

Section: Blood Sampling Sitementioning

confidence: 99%

See 3 more Smart Citations

Prognostic significance of circulating tumour cells following surgical resection of colorectal cancers: a systematic review

et al. 2010

View full text Add to dashboard Cite

show abstract

Serum sE‐selectin levels and carcinoembryonic antigen mRNA‐expressing cells in peripheral blood as prognostic factors in colorectal cancer patients

Ferroni

Roselli

Spila

et al. 2010

Cancer

View full text Add to dashboard Cite

BACKGROUND: This study analyzed the possible prognostic value of presurgical serum soluble (s)E-selectin levels and/or carcinoembryonic antigen (CEA) mRNA positivity in predicting the disease-free survival of colorectal cancer (CRC) patients. METHODS: CEA mRNA (obtained from blood-borne cells by reverse transcriptase-polymerase chain reaction [RT-PCR]), tumor necrosis factor-a (TNF-a), and sE-selectin levels were analyzed in blood samples obtained from 78 patients with primary (n ¼ 62) or recurrent (n ¼ 16) CRC, 40 patients with benign colorectal (CR) diseases, and 78 controls. RESULTS: CEA mRNA positivity by RT-PCR was significantly associated with advanced stage (P < .05). Median baseline sE-selectin levels were higher in patients with CRC (43 ng/mL) compared with controls (36 ng/mL) or patients with benign CR diseases (31 ng/mL, P < .001). These were significantly associated with CEA mRNA positivity by RT-PCR (P < .05). Multivariate analysis by forward stepping showed that elevated TNF-a (P ¼ .001) and CEA mRNA positivity by RT-PCR (P ¼ .0001) were independent predictors of elevated baseline sE-selectin levels. Positive presurgical sE-selectin levels were associated with an increased recurrence rate compared with patients with low levels of this molecule (P < .001). Positivity for both CEA mRNA and sE-selectin had a negative prognostic impact, with a 5-year recurrence-free survival rate of 51% compared with 95% of patients with negative parameters (P < .05). CONCLUSIONS: Detection of presurgical serum sE-selectin levels and CEA mRNA-positive blood-borne cells in CRC patients might provide useful prognostic information in terms of recurrence-free survival, either alone or in combination, and may help in the choice of more aggressive treatment and/or more strict follow-up procedures in high-risk patients.

show abstract

Cellules Circulantes Tumorales Après Résection D’un Cancer Colorectal: Un Marqueur Pronostique Fort!

Artru¹,

Lledo²

2007

Acta Endosc

View full text Add to dashboard Cite

Detection of Carcinoembryonic Antigen Messenger RNA-Expressing Cells in Peripheral Blood 7 Days After Curative Surgery is a Novel Prognostic Factor in Colorectal Cancer

Abstract: Detection of CEA mRNA expressing cells in peripheral blood 7 days after curative surgery is a novel independent factor predicting recurrence in patients with CRC.

Cited by 39 publications

References 24 publications

Prognostic significance of circulating tumour cells following surgical resection of colorectal cancers: a systematic review

Prognostic significance of circulating tumour cells following surgical resection of colorectal cancers: a systematic review

Serum sE‐selectin levels and carcinoembryonic antigen mRNA‐expressing cells in peripheral blood as prognostic factors in colorectal cancer patients

Cellules Circulantes Tumorales Après Résection D’un Cancer Colorectal: Un Marqueur Pronostique Fort!

Contact Info

Product

Resources

About