Detection of Carcinoembryonic Antigen Messenger RNA–Expressing Cells in Portal and Peripheral Blood During Surgery Does Not Influence Relapse in Colorectal Cancer
“…The 14 studies included here comprised 1841 patients in total, with the median number of patients in each study being 99.5 (range 42 -438) (Taniguchi et al, 2000;Yamaguchi et al, 2000;Ito et al, 2002;Bessa et al, 2003;Chen et al, 2004;Sadahiro et al, 2005Sadahiro et al, , 2007Katsumata et al, 2006;Koch et al, 2006;Lloyd et al, 2006;Allen-Mersh et al, 2007;Uen et al, 2007Uen et al, , 2008Wang et al, 2007).…”
Section: Study Characteristicsmentioning
confidence: 99%
“…Of the 14 studies included, eight undertook blood sampling perioperatively (Taniguchi et al, 2000;Yamaguchi et al, 2000;Ito et al, 2002;Chen et al, 2004;Sadahiro et al, 2005;Katsumata et al, 2006;Koch et al, 2006;Lloyd et al, 2006), four undertook sampling approximately 24 h after resection (Bessa et al, 2003;Koch et al, 2006;Lloyd et al, 2006;Allen-Mersh et al, 2007), and six undertook sampling between 24 h and 14 days after resection (Chen et al, 2004; Allen-Mersh et al, 2007;Sadahiro et al, 2007;Uen et al, 2007Uen et al, , 2008Wang et al, 2007).…”
Section: Study Characteristicsmentioning
confidence: 99%
“…Seven investigated the role of CTC in patients with stage-I to stage-III disease undergoing potentially curative surgery (Ito et al, 2002;Bessa et al, 2003;Sadahiro et al, 2005Sadahiro et al, , 2007Allen-Mersh et al, 2007;Wang et al, 2007;Uen et al, 2008); three studied CTC in patients with early CRC (of which two investigated stage-II disease alone (Koch et al, 2006;Uen et al, 2007) and one investigated stage-I and stage-II disease (Lloyd et al, 2006)); and four papers included patients with stage-I to stage-IV disease (Taniguchi et al, 2000;Yamaguchi et al, 2000;Chen et al, 2004;Katsumata et al, 2006).…”
Section: Tumour Stagementioning
confidence: 99%
“…Of the 14 studies included in our analysis, 10 involved sampling of peripheral blood only (Ito et al, 2002;Bessa et al, 2003;Chen et al, 2004;Katsumata et al, 2006;Lloyd et al, 2006;Allen-Mersh et al, 2007;Sadahiro et al, 2007;Uen et al, 2007Uen et al, , 2008Wang et al, 2007); 1 used peripheral and portal blood samples (Sadahiro et al, 2005); 1 used peripheral and mesenteric samples (Yamaguchi et al, 2000); 1 used peripheral, portal and mesenteric samples (Taniguchi et al, 2000); and 1 used samples of central venous blood (Koch et al, 2006).…”
Background:
The role of adjuvant chemotherapy after resection of colorectal cancers (CRCs) is well understood for patients with stage-I or stage-III disease. Its efficacy for those with stage-II disease remains much less clear. Many investigators have sought to identify prognostic markers that might clarify which patients have the highest risk of recurrence and would, therefore, be most likely to benefit from chemotherapy. This systematic review examines evidence for the use of peripherally sampled, circulating tumour cells (CTCs) as such a prognostic marker.
Methods:
A comprehensive literature search was used to identify studies reporting on the significance of CTCs in the postoperative blood of CRC patients.
Results:
Fourteen studies satisfied the inclusion criteria. Six of the nine studies that took blood samples 24 h or more postoperatively found detection of postoperative CTCs to be an independent predictor of cancer recurrence.
Conclusion:
The presence of CTCs in peripheral blood at least 24 h after resection of CRCs is an independent prognostic marker of recurrence. Further studies are needed to clarify the optimal time point for blood sampling and determine the benefit of chemotherapy in CTC-positive patients with stage-II disease.
“…The 14 studies included here comprised 1841 patients in total, with the median number of patients in each study being 99.5 (range 42 -438) (Taniguchi et al, 2000;Yamaguchi et al, 2000;Ito et al, 2002;Bessa et al, 2003;Chen et al, 2004;Sadahiro et al, 2005Sadahiro et al, , 2007Katsumata et al, 2006;Koch et al, 2006;Lloyd et al, 2006;Allen-Mersh et al, 2007;Uen et al, 2007Uen et al, , 2008Wang et al, 2007).…”
Section: Study Characteristicsmentioning
confidence: 99%
“…Of the 14 studies included, eight undertook blood sampling perioperatively (Taniguchi et al, 2000;Yamaguchi et al, 2000;Ito et al, 2002;Chen et al, 2004;Sadahiro et al, 2005;Katsumata et al, 2006;Koch et al, 2006;Lloyd et al, 2006), four undertook sampling approximately 24 h after resection (Bessa et al, 2003;Koch et al, 2006;Lloyd et al, 2006;Allen-Mersh et al, 2007), and six undertook sampling between 24 h and 14 days after resection (Chen et al, 2004; Allen-Mersh et al, 2007;Sadahiro et al, 2007;Uen et al, 2007Uen et al, , 2008Wang et al, 2007).…”
Section: Study Characteristicsmentioning
confidence: 99%
“…Seven investigated the role of CTC in patients with stage-I to stage-III disease undergoing potentially curative surgery (Ito et al, 2002;Bessa et al, 2003;Sadahiro et al, 2005Sadahiro et al, , 2007Allen-Mersh et al, 2007;Wang et al, 2007;Uen et al, 2008); three studied CTC in patients with early CRC (of which two investigated stage-II disease alone (Koch et al, 2006;Uen et al, 2007) and one investigated stage-I and stage-II disease (Lloyd et al, 2006)); and four papers included patients with stage-I to stage-IV disease (Taniguchi et al, 2000;Yamaguchi et al, 2000;Chen et al, 2004;Katsumata et al, 2006).…”
Section: Tumour Stagementioning
confidence: 99%
“…Of the 14 studies included in our analysis, 10 involved sampling of peripheral blood only (Ito et al, 2002;Bessa et al, 2003;Chen et al, 2004;Katsumata et al, 2006;Lloyd et al, 2006;Allen-Mersh et al, 2007;Sadahiro et al, 2007;Uen et al, 2007Uen et al, , 2008Wang et al, 2007); 1 used peripheral and portal blood samples (Sadahiro et al, 2005); 1 used peripheral and mesenteric samples (Yamaguchi et al, 2000); 1 used peripheral, portal and mesenteric samples (Taniguchi et al, 2000); and 1 used samples of central venous blood (Koch et al, 2006).…”
Background:
The role of adjuvant chemotherapy after resection of colorectal cancers (CRCs) is well understood for patients with stage-I or stage-III disease. Its efficacy for those with stage-II disease remains much less clear. Many investigators have sought to identify prognostic markers that might clarify which patients have the highest risk of recurrence and would, therefore, be most likely to benefit from chemotherapy. This systematic review examines evidence for the use of peripherally sampled, circulating tumour cells (CTCs) as such a prognostic marker.
Methods:
A comprehensive literature search was used to identify studies reporting on the significance of CTCs in the postoperative blood of CRC patients.
Results:
Fourteen studies satisfied the inclusion criteria. Six of the nine studies that took blood samples 24 h or more postoperatively found detection of postoperative CTCs to be an independent predictor of cancer recurrence.
Conclusion:
The presence of CTCs in peripheral blood at least 24 h after resection of CRCs is an independent prognostic marker of recurrence. Further studies are needed to clarify the optimal time point for blood sampling and determine the benefit of chemotherapy in CTC-positive patients with stage-II disease.
“…The expression levels of CK-7 and CK-19 showed high sensitivity and specificity for the identification of gastric cancer cells in comparison with the other markers (Masuda et al, 2005). Those epithelial cell markers have been widely used as target genes for the detection of ITCs (Mori et al, 1996(Mori et al, , 1998Yamaguchi et al, 2000;Bessa et al, 2003;Sadahiro et al, 2005). Thus, CEA, CK-7, CK-19 and GAPDH were studied by quantitative RT -PCR in all 846 patients (Mimori et al, 2008).…”
Section: Primers and Probes For Detecting Itcs And Upar Expressionmentioning
Urokinase-type plasminogen activator receptor (uPAR) plays a central role in the plasminogen activation cascade and participates in extracellular matrix degradation, cell migration and invasion. We evaluated the expression level of uPAR mRNA and the presence of isolated tumour cells (ITCs) in bone marrow (BM) and peripheral blood (PB) in gastric cancer patients and clarified its clinical significance. We assessed specific uPAR mRNA expression by quantitative real-time reverse transcriptase-polymerase chain reaction (RT -PCR) in BM and PB in 846 gastric cancer patients as well as three epithelial cell markers, carcinoembryonic antigen (CEA), cytokeratin (CK)-19 and CK-7. The uPAR mRNA expression in bone marrow and peripheral blood expressed significantly higher than normal controls (Po0.0001). The uPAR mRNA in BM showed concordant expression with the depth of tumour invasion, distant metastasis, and the postoperative recurrence (P ¼ 0.015, 0.044 and 0.010, respectively); whereas in PB, we observed more intimate significant association between uPAR expression and clinicopathologic variables, such as depth of tumour invasion, the distant metastasis, the venous invasion and the clinical stage (P ¼ 0.009, 0.002, 0.039 and 0.008, respectively). In addition, the uPAR mRNA expression in PB was an independent prognostic factor for distant metastasis by multivariate analysis. We disclosed that it was possible to identify high-risk patients for distant metastasis by measuring uPAR mRNA especially in peripheral blood at the timing of operation in gastric cancer patients.
The most common site of metastases in patients with colorectal cancer is the liver. Hepatic resection is considered to be the treatment of choice for liver metastasis from colorectal cancer; however, hepatic resection can be performed in only 20 or 25% of all patients. Recurrence develops in the remnant liver or other organs after hepatic resection in over half of all patients with liver-only metastasis. Hepatic arterial infusion (HAI) chemotherapy can provide relatively high concentrations of drugs to microscopic or macroscopic metastases in the liver, with less toxicity than systemic administration. Meta-analyses have shown HAI chemotherapy to have a significantly higher response rate than systemic chemotherapy and its effect on extrahepatic metastases is negligible. HAI chemotherapy provides much better local control of liver metastases from colorectal cancer than systemic chemotherapy. However, well-controlled studies are needed to elucidate the optimal treatment strategies for neoadjuvant and postoperative adjuvant chemotherapy that optimally combine HAI chemotherapy, molecular targeted agents, and systemic chemotherapy such as FOLFOX or FOLFIRI.
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