Detection of canine batten disease with the EEG

Burcar, Patricia J.; Armstrong, Donald; Koppang, N.; Lewis, James A.; Johnson, Susan M.; Neville, Hans E.

doi:10.1016/0013-4694(77)90157-2

Cited by 11 publications

(4 citation statements)

References 7 publications

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“…A d.c. tech nique was used, comprising contact lenses, calomel electrodes and low-drift d.c. amplifiers [19], The am plitude changes in the standing potential (SP) of the eye in response to a step from darkness to light was also recorded directly, using the same technique as above, between the cornea and the forehead [20]. The EEG was taken with an 8-channel electroencephalo graph [10].…”

Section: Methodsmentioning

confidence: 99%

“…Abnormalities in the EEG are apparent even at 6 months of age and these progress until the tracings are isoelectric in the adult animal [10]. These changes consist of early high-voltage slow waves with spikes, becom ing increasingly more disorganized and final ly, electrical activity ceases.…”

Section: Electrophysiologymentioning

confidence: 99%

“…Breeders of offspring with diagnosed CCL were then contacted and a breeding program begun in 1959. This resulted in producing sufficient dogs to determine that the canine disorder was inherited as an autosomal reces sive [9], Extensive pathological, histochemical and electrophysiological studies have confirmed the English setter as a model of the human disease [8,10], However, the dogs do differ somewhat from humans in their retinal abnormality. Whereas humans show total loss of photoreceptors and severe damage to the pigment epithelium (RPE), these areas are relatively intact in the dog [11], even though they harbor massive amounts of autofluorescent ceroid [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Canine Hereditary Ceroid Lipofuscinosis

1982

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Dogs with an inherited form of ceroid lipofuscinosis are ataxic, blind and demented. During the disease process, they undergo severe cerebrocerebellar atrophy with storage of autofluorescent, lipid peroxide-positive reacting substances whose ultrastructure resembles ‘fingerprint’ patterns of membranous lamellae. The retina and RPE also undergo pathologic changes. Most important is the inverse relationship between loss of RPE melanin and increased deposition of ceroid. These pathological events in brain and eye lead to altered EEG, ERG and VEP activity. This inbred strain of English setters fulfills essentially all the criteria as a model for the human disease and will prove useful in the future for therapeutic trials.

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Section: Methodsmentioning

confidence: 99%

Section: Electrophysiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Canine Hereditary Ceroid Lipofuscinosis

1982

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“…While these features are shared with most research animals, dogs have been argued similar to humans in ways that overshadow the more widely used rodent model (Topál et al 2009;Bunford et al 2017) and which is likely a consequence of their adaptation to the anthropogenic environment (Miklósi 2014). In addition to being potentially helpful in understanding processes relevant for human medicine, dogs are themselves the target of clinical efforts and there have been attempts to transform canine EEG into a diagnostic tool for veterinarians (Croft 1962;Burcar et al 1977;Pákozdy et al 2012). In conclusion, dogs occupy a unique niche within the range of possible animal models.…”

Section: The Brief History Of Canine Eeg and The Importance Of Compar...mentioning

confidence: 99%

The dog as a model-animal in comparative sleep spindle research

Borislavov¹

2020

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Dr. Enikő Kubinyi, who supervised this thesis and the efforts that are described hereafter. She trusted my ability when my curriculum vitae could not speak up for me, yet, and provided the necessary means and support for this project to work. Our written exchanges while working on manuscripts together, helped me develop ideas and map my way through the relevant literature. She took the time and patience to review and promote all ideas that came to my mind, while making sure the most urgent goals do not leave our sight. Dr. Gilles van Luijtelaar, who supervised my bachelor and master theses. Who took the time to discuss neuroscience on almost philosophical levels of depth and continued to support me, morally and academically, long after his official role as my teacher had ended. His dry and confrontational, yet cordial humor were always uplifting the spirit of our interactions. Dr. Hein van Schie who supervised my first literature study in psychology and continued to explore ideas with me long after I left the Radboud University of Nijmegen. One of our literature studies became my first publication, which helped me regain confidence in a difficult time. Dr. Torfi Sigurdsson, who after a time that was hard for both of us, did not take it personal that we were a bad match.From the senior university teachers/professors with whom I interacted, but were not my direct/official supervisors I would like to thank:Dr. Arno Koning who first taught me academic writing, the late Dr. Jacques Janssen, Dr. Pieter Medendorp and his then PhD students, now Dr. Frank Léoné and Dr. Ivar Clemens who taught me to use Matlab, our faculty's Statistics professor Dr. Jules Ellis, Dr. Tineke van Rijn for knowing how to ignite interest in brain anatomy and physiology, all of above associated with the Radboud University of Nijmegen. Dr. Jochen Roeper who kept up the intellectual spirit in the otherwise worldly Frankfurt. In the ELTE department of ethology I also had the honor to meet and learn from Dr. Ádám Miklósi, Dr. Attila Andics (whose efforts in organizing the department retreats gave me a chance to socialize more directly with many colleagues), Dr. Péter Pongrácz (whom I thank a visit to a life animal market and my first experiences as a peer-reviewer), Dr. Ákos Pogány and Dr. Tamás Faragó (these two I want to also thank specifically for engaging the department in short-lived, but fun musical projects). I am also grateful for meeting Dr. Claudia Fugazza and Dr. Márta Gácsi and having the opportunity to ask some direct questions about their interesting lines of work. A very special thanks also to Dr. Dorottya Júlia Ujfalussy, for helping out with some highly relevant bureaucratic pressures right in the beginning of my stay (but in that regard also I want to mention and thank Boróka Bereczky, Ágnes Modrovics and Borbála Győri).I would next like to thank a few personal friends from within academia, who at times unofficially acted as "secondary" or "supporting" supervisors, as well as those who worked with me towards shared goals:

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Bibliography on ceroid-lipofuscinoses

Black

Pullarkat

Opitz³

1988

Am. J. Med. Genet.

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INTRODUCTIONThis comprehensive international bibliography includes citations to journal articles, monographs and chapters of books concerned with ceroid-lipofuscinoses. The bibliography also contains papers on animal models, and references to the following human diseases: Hagberg-Santavuori (infantile), Jansky-Bielschowsky (late-infantile), Batten-Spielmeyer-Vogt-Sjogren (juvenile), and Kuf (adult).

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Detection of canine batten disease with the EEG

Cited by 11 publications

References 7 publications

Canine Hereditary Ceroid Lipofuscinosis

Canine Hereditary Ceroid Lipofuscinosis

The dog as a model-animal in comparative sleep spindle research

Bibliography on ceroid-lipofuscinoses

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